Subunits interactions in kinesin motors

European Journal of Cell Biology

Volumn 86, Issue 9, 2007, Pages 559-568

  Skowronek, Krzysztof J ^a   Kocik, Elzbieta ^a   Kasprzak, Andrzej A ^a  

^a NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

Author keywords

Dimer; Kinesin; Microtubule; Molecular motor; Processivity; Strain

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASE; CARRIER PROTEIN; KINESIN; MOLECULAR MOTOR; PROTEIN DERIVATIVE; PROTEIN SUBUNIT;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; BINDING AFFINITY; BINDING SITE; CELL DIVISION; CELL FUNCTION; CRYSTAL STRUCTURE; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME RELEASE; GENE MUTATION; GENETIC CODE; HYDROLYSIS; MECHANOTRANSDUCTION; MICROTUBULE; MOLECULAR MODEL; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DETERMINATION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; SHORT SURVEY; SYNAPTIC TRANSMISSION;

EID: 34547758084     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcb.2007.05.008     Document Type: Short Survey

References (69)

1. Adio S., Bloemink M., Hartel M., Leier S., Geeves M.A., and Woehlke G. Kinetic and mechanistic basis of the nonprocessive kinesin-3 motor NcKin3. J. Biol. Chem. 281 (2006) 37782-37793
2. Al-Bassam J., Cui Y., Klopfenstein D., Carragher B.O., Vale R.D., and Milligan R.A. Distinct conformations of the kinesin Unc104 neck regulate a monomer to dimer motor transition. J. Cell Biol. 163 (2003) 743-753
3. Alonso M.C., van Damme J., Vandekerckhove J., and Cross R.A. Proteolytic mapping of kinesin/Ncd-microtubule interface: nucleotide-dependent conformational changes in the loops L8 and L12. EMBO J. 17 (1998) 945-951
4. Alonso M.C., Drummond D.R., Kain S., Hoeng J., Amos L., and Cross R.A. An ATP gate controls tubulin binding by the tethered head of kinesin-1. Science 316 (2007) 120-123
5. Asbury C.L., Fehr A.N., and Block S.M. Kinesin moves by an asymmetric hand-over-hand mechanism. Science 302 (2003) 2130-2134
6. Block S.M., and Svoboda K. Analysis of high resolution recordings of motor movement. Biophys. J. 68 Suppl. 4 (1995) 230S-239S discussion 239S-241S
7. Carter N.J., and Cross R.A. Mechanics of the kinesin step. Nature 435 (2005) 308-312
8. Coy D.L., Wagenbach M., and Howard J. Kinesin takes one 8-nm step for each ATP that it hydrolyzes. J. Biol. Chem. 274 (1999) 3667-3671
9. Crevel I.M.-T.C., Nyitrai M., Alonso M.C., Weiss S., Geeves M.A., and Cross R.A. What kinesin does at roadblocks: the coordination mechanism for molecular walking. EMBO J. 23 (2004) 23-32
10. Cross R.A. On the hand-over-hand footsteps of kinesin heads. J. Muscle Res. Cell Motil. 16 (1995) 91-94
11. Cross R.A. The kinetic mechanism of kinesin. Trends Biochem. Sci. 29 (2004) 301-309
12. Endres N.F., Yoshioka C., Milligan R.A., and Vale R.D. A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd. Nature 439 (2006) 875-878
13. Fink G., Schuchardt I., Colombelli J., Stelzer E., and Steinberg G. Dynein-mediated pulling forces drive rapid mitotic spindle elongation in Ustilago maydis. EMBO J. 25 (2006) 4897-4908
14. Foster K.A., Correia J.J., and Gilbert S.P. Equilibrium binding studies of non-claret disjunctional protein (Ncd) reveal cooperative interactions between the motor domains. J. Biol. Chem. 273 (1998) 35307-35318
15. Foster K.A., Mackey A.T., and Gilbert S.P. A mechanistic model for Ncd directionality. J. Biol. Chem. 276 (2001) 19259-19266
16. Gilbert S.P., Webb M.R., Brune M., and Johnson K.A. Pathway of processive ATP hydrolysis by kinesin. Nature 373 (1995) 671-676
17. Goshima G., Nedelec F., and Vale R.D. Mechanisms for focusing mitotic spindle poles by minus end-directed motor proteins. J. Cell Biol. 171 (2005) 229-240
18. Guydosh N.R., and Block S.M. Backsteps induced by nucleotide analogs suggest the front head of kinesin is gated by strain. Proc. Natl. Acad. Sci. USA 103 (2006) 8054-8059
19. Hackney D.D. Kinesin ATPase: rate-limiting ADP release. Proc. Natl. Acad. Sci. USA 85 (1988) 6314-6318
20. Hackney D.D. Evidence for alternating head catalysis by kinesin during microtubule-stimulated ATP hydrolysis. Proc. Natl. Acad. Sci. USA 91 (1994) 6865-6869
21. Hahlen K., Ebbing B., Reinders J., Mergler J., Sickmann A., and Woehlke G. Feedback of the kinesin-1 neck-linker position on the catalytic site. J. Biol. Chem. 281 (2006) 18868-18877
22. Hajdo L., Skowronek K., and Kasprzak A.A. Spatial relationship between heads of dimeric Ncd in the presence of nucleotides and microtubules. Arch. Biochem. Biophys. 421 (2004) 217-226
23. Heck M.M., Pereira A., Pesavento P., Yannoni Y., Spradling A.C., and Goldstein L.S. The kinesin-like protein KLP61F is essential for mitosis in Drosophila. J. Cell Biol. 123 (1993) 665-679
24. Higuchi H., Bronner C.E., Park H.W., and Endow S.A. Rapid double 8-nm steps by a kinesin mutant. EMBO J. 23 (2004) 2993-2999
25. Hoenger A., Thormahlen M., Diaz-Avalos R., Doerhoefer M., Goldie K.N., Muller J., and Mandelkow E. A new look at the microtubule binding patterns of dimeric kinesins. J. Mol. Biol. 297 (2000) 1087-1103
26. Howard J. Molecular motors: structural adaptations to cellular functions. Nature 389 (1997) 561-567
27. Hua W., Young E.C., Fleming M.L., and Gelles J. Coupling of kinesin steps to ATP hydrolysis. Nature 388 (1997) 390-393
28. Hua W., Chung J., and Gelles J. Distinguishing inchworm and hand-over-hand processive kinesin movement by neck rotation measurements. Science 295 (2002) 844-848
29. Hyeon C., and Onuchic J.N. Internal strain regulates the nucleotide binding site of the kinesin leading head. Proc. Natl. Acad. Sci. USA 104 (2007) 2175-2180
30. Kapitein L.C., Peterman E.J., Kwok B.H., Kim J.H., Kapoor T.M., and Schmidt C.F. The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks. Nature 435 (2005) 114-118
31. Kaseda K., Higuchi H., and Hirose K. Coordination of kinesin's two heads studied with mutant heterodimers. Proc. Natl. Acad. Sci. USA 99 (2002) 16058-16063
32. Kaseda K., Higuchi H., and Hirose K. Alternate fast and slow stepping of a heterodimeric kinesin molecule. Nat. Cell Biol. 5 (2003) 1079-1082
33. Klopfenstein D.R., Tomishige M., Stuurman N., and Vale R.D. Role of phosphatidylinositol(4,5)bisphosphate organization in membrane transport by the Unc104 kinesin motor. Cell 109 (2002) 347-358
34. Klumpp S., and Lipowsky R. Cooperative cargo transport by several molecular motors. Proc. Natl. Acad. Sci. USA 102 (2005) 17284-17289
35. Klumpp L.M., Hoenger A., and Gilbert S.P. Kinesin's second step. Proc. Natl. Acad. Sci. USA 101 (2004) 3444-3449
36. Kozielski F., De Bonis S., Burmeister W.P., Cohen-Addad C., and Wade R.H. The crystal structure of the minus-end-directed microtubule motor protein Ncd reveals variable dimer conformations. Structure 7 (1999) 1407-1416
37. Krzysiak T.C., and Gilbert S.P. Dimeric Eg5 maintains processivity through alternating-site catalysis with rate-limiting ATP hydrolysis. J. Biol. Chem. 281 (2006) 39444-39454
38. Kwok B.H., Kapitein L.C., Kim J.H., Peterman E.J., Schmidt C.F., and Kapoor T.M. Allosteric inhibition of kinesin-5 modulates its processive directional motility. Nat. Chem. Biol. 2 (2006) 480-485
39. Leibler S., and Huse D.A. Porters versus rowers: a unified stochastic model of motor proteins. J. Cell Biol. 121 (1993) 1357-1368
40. Mackey A.T., and Gilbert S.P. Moving a microtubule may require two heads: a kinetic investigation of monomeric Ncd. Biochemistry 39 (2000) 1346-1355
41. Muto E., Sakai H., and Kaseda K. Long-range cooperative binding of kinesin to a microtubule in the presence of ATP. J. Cell Biol. 168 (2005) 691-696
42. Okada Y., and Hirokawa N. Mechanism of the single-headed processivity: diffusional anchoring between the K-loop of kinesin and the C-terminus of tubulin. Proc. Natl. Acad. Sci. USA 97 (2000) 640-645
43. Pechatnikova E., and Taylor E.W. Kinetics processivity and the direction of motion of Ncd. Biophys. J. 77 (1999) 1003-1016
44. Purcell T.J., Sweeney H.L., and Spudich J.A. A force-dependent state controls the coordination of processive myosin V. Proc. Natl. Acad. Sci. USA 102 (2005) 13873-13878
45. Rogers K.R., Weiss S., Crevel I., Brophy P.J., Geeves M., and Cross R. KIF1D is a fast non-processive kinesin that demonstrates novel K-loop-dependent mechanochemistry. EMBO J. 20 (2001) 5101-5113
46. Rosenfeld S.S., Fordyce P.M., Jefferson G.M., King P.H., and Block S.M. Stepping and stretching. How kinesin uses internal strain to walk processively. J. Biol. Chem. 278 (2003) 18550-18556
47. Sablin E.P., Kull F.J., Cooke R., Vale R.D., and Fletterick R.J. Crystal structure of the motor domain of the kinesin-related motor Ncd. Nature 380 (1996) 555-559
48. Sawin K.E., LeGuellec K., Philippe M., and Mitchison T.J. Mitotic spindle organization by a plus-end-directed microtubule motor. Nature 359 (1992) 540-543
49. Schief W.R., Clark R.H., Crevenna A.H., and Howard J. Inhibition of kinesin motility by ADP and phosphate supports a hand-over-hand mechanism. Proc. Natl. Acad. Sci. USA 101 (2004) 1183-1188
50. Schnitzer M.J., and Block S.M. Kinesin hydrolyses one ATP per 8-nm step. Nature 388 (1997) 386-390
51. Sharp D.J., McDonald K.L., Brown H.M., Matthies H.J., Walczak C., Vale R.D., Mitchison T.J., and Scholey J.M. The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles. J. Cell Biol. 144 (1999) 125-138
52. Skold H.N., Komma D.J., and Endow S.A. Assembly pathway of the anastral Drosophila oocyte meiosis I spindle. J. Cell Sci. 118 (2005) 1745-1755
53. Skowronek K., and Kasprzak A.A. A two-plasmid system for independent genetic manipulation of subunits of homodimeric proteins and selective isolation of chimeric dimers. Anal. Biochem. 300 (2002) 185-191
54. Tao L., Mogilner A., Civelekoglu-Scholey G., Wollman R., Evans J., Stahlberg H., and Scholey J.M. A homotetrameric kinesin-5, KLP61F, bundles microtubules and antagonizes Ncd in motility assays. Curr. Biol. 16 (2006) 2293-2302
55. Thorn K.S., Ubersax J.A., and Vale R.D. Engineering the processive run length of the kinesin motor. J. Cell Biol. 151 (2000) 1093-1100
56. Tomishige M., Klopfenstein D.R., and Vale R.D. Conversion of Unc104/KIF1A kinesin into a processive motor after dimerization. Science 297 (2002) 2263-2267
57. Tomishige M., Stuurman N., and Vale R.D. Single-molecule observations of neck linker conformational changes in the kinesin motor protein. Nat. Struct. Mol. Biol. 13 (2006) 887-894
58. Uemura S., and Ishiwata S. Loading direction regulates the affinity of ADP for kinesin. Nat. Struct. Biol. 10 (2003) 308-311
59. Uemura S., Kawaguchi K., Yajima J., Edamatsu M., Toyoshima Y.Y., and Ishiwata S. Kinesin-microtubule binding depends on both nucleotide state and loading direction. Proc. Natl. Acad. Sci. USA 99 (2002) 5977-5981
60. Vale R.D., Coppin C.M., Malik F., Kull F.J., and Milligan R.A. Tubulin GTP hydrolysis influences the structure, mechanical properties, and kinesin-driven transport of microtubules. J. Biol. Chem. 269 (1994) 23769-23775
61. Valentine M.T., Fordyce P.M., Krzysiak T.C., Gilbert S.P., and Block S.M. Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro. Nat. Cell Biol. 8 (2006) 470-476
62. Vilfan A., Frey E., Schwabl F., Thormahlen M., Song Y.H., and Mandelkow E. Dynamics and cooperativity of microtubule decoration by the motor protein kinesin. J. Mol. Biol. 312 (2001) 1011-1026
63. Woehlke G., Ruby A.K., Hart C.L., Ly B., Hom-Booher N., and Vale R.D. Microtubule interaction site of the kinesin motor. Cell 90 (1997) 207-216
64. Xie P., Dou S.-X., and Wang P.-Y. Limping of homodimeric kinesin motors. J. Mol. Biol. 366 (2007) 976-985
65. Yildiz A., and Selvin P.R. Fluorescence imaging with one nanometer accuracy: application to molecular motors. Acc. Chem. Res. 38 (2005) 574-582
66. Yildiz A., Forkey J.N., McKinney S.A., Ha T., Goldman Y.E., and Selvin P.R. Myosin V walks hand-over-hand: single fluorophore imaging with 1.5-nm localization. Science 300 (2003) 2061-2065
67. Yildiz A., Park H., Safer D., Yang Z., Chen L.Q., Selvin P.R., and Sweeney H.L. Myosin VI steps via a hand-over-hand mechanism with its lever arm undergoing fluctuations when attached to actin. J. Biol. Chem. 279 (2004) 37223-37226
68. Yildiz A., Tomishige M., Vale R.D., and Selvin P.R. Kinesin walks hand-over-hand. Science 303 (2004) 676-678
69. Yun M., Bronner C.E., Park C.G., Cha S.S., Park H.W., and Endow S.A. Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd. EMBO J. 22 (2003) 5382-5389