Trypsin inhibitory loop is an excellent lead structure to design serine protease inhibitors and antimicrobial peptides

FASEB Journal

Volumn 21, Issue 10, 2007, Pages 2466-2473

  Li, Jianxu ^a,f   Zhang, Cheng ^b,e   Xu, Eqing ^a,f   Wang, Jie ^b,e   Yu, Haining ^d   Lai, Ren ^a,c   Gong, Weimin ^b  

^a KUNMING INSTITUTE OF ZOOLOGY   (China)

^b INSTITUTE OF BIOPHYSICS   (China)

^c NANJING AGRICULTURAL UNIVERSITY   (China)

^d HEBEI NORMAL UNIVERSITY   (China)

^e UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^f UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Trypsin resistance

Indexed keywords

ALANYLALANYLLEUCYLLYSYLGLYCYLCYSTEINYLTRYPTOPHANYLTHREONYLLYSYLSERYLISOLEUCYLPROLYLPROLYLLYSYLPROLYLCYSTEINYLPHENYLALANYLGLYCYLLYSYLARGININE; ALANYLALANYLLEUCYLLYSYLGLYCYLCYSTEINYLTRYPTOPHANYLTHREONYLLYSYLSERYLISOLEUCYLPROLYLPROLYLLYSYLPROLYLCYSTEINYLPHENYLALANYLGLYCYLPHENYLALANINE; ALANYLLEUCYLLYSYLGLYCYLCYSTEINYLTRYPTOPHANYLTHREONYLLYSYLSERYLISOLEUCYLPROLYLPROLYLLYSYLPROLYLCYSTEINYLPHENYLALANYLGLYCYLLYSINE; CYSTEINYLTRYPTOPHANYLTHREONYLLYSYLSERYLISOLEUCYLPROLYLPROLYLLYSYLPROLYLCYSTEINE; CYSTEINYLTRYPTOPHANYLTHREONYLLYSYLSERYLISOLEUCYLPROLYLPROLYLLYSYLPROLYLCYSTEINYLPHENYLALANINE; CYSTEINYLTRYPTOPHANYLTHREONYLLYSYLSERYLISOLEUCYLPROLYLPROLYLLYSYLPROLYLGLYCINE; GLYCYLCYSTEINYLTRYPTOPHANYLTHREONYLLYSYLSERYLISOLEUCYLPROLYLPROLYLLYSYLPROLYLCYSTEINYLPHENYLALANINE; LEUCYLLYSYLGLYCYLCYSTEINYLTRYPTOPHANYLTHREONYLLYSYLSERYLISOLEUCYLPROLYLPROLYLLYSYLPROLYLCYSTEINYLPHENYLALANINE; LEUCYLLYSYLGLYCYLCYSTEINYLTRYPTOPHANYLTHREONYLLYSYLSERYLISOLEUCYLPROLYLPROLYLLYSYLPROLYLCYSTEINYLPHENYLALANYLGLYCINE; LEUCYLLYSYLGLYCYLCYSTEINYLTRYPTOPHANYLTHREONYLLYSYLSERYLISOLEUCYLPROLYLPROLYLLYSYLPROLYLCYSTEINYLPHENYLALANYLGLYCYLGLYCINE; LEUCYLLYSYLGLYCYLCYSTEINYLTRYPTOPHANYLTHREONYLLYSYLSERYLISOLEUCYLPROLYLPROLYLLYSYLPROLYLCYSTEINYLPHENYLALANYLGLYCYLPHENYLALANINE; LEUCYLLYSYLGLYCYLCYSTEINYLTRYPTOPHANYLTHREONYLLYSYLSERYLISOLEUCYLPROLYLPROLYLLYSYLPROLYLCYSTEINYLPHENYLALANYLGLYCYLYSINE; POLYPEPTIDE ANTIBIOTIC AGENT; SERINE PROTEINASE INHIBITOR; TRYPSIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CANDIDA ALBICANS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ISOLATION; DRUG PROTEIN BINDING; ELECTRON MICROSCOPY; ESCHERICHIA COLI; FEMALE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; DRUG DESIGN; PEPTIDE FRAGMENTS; PROTEASE INHIBITORS; PROTEIN CONFORMATION; RANIDAE; SKIN; TRYPSIN; TRYPSIN INHIBITORS;

AMPHIBIA;

EID: 34547753063     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-7966com     Document Type: Article

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