Compact subnanosecond pulse generator using avalanche transistors for cell electroperturbation studies

IEEE Transactions on Dielectrics and Electrical Insulation

Volumn 14, Issue 4, 2007, Pages 873-877

  Krishnaswamy, Pavitra ^a   Kuthi, Andras ^a   Vernier, P Thomas ^a   Gundersen, Martin A ^a  

^a University of Southern California ^*  (United States)

Author keywords

Avalanche breakdown; Bioelectric phenomena; Biomembranes; Electroperturbation; Pulse power systems; Voltage dividers

Indexed keywords

BIOELECTRIC PHENOMENA; CELLS; ELECTRIC LINES; PERTURBATION TECHNIQUES; TRANSISTORS; VOLTAGE DIVIDERS;

AVALANCHE TRANSISTORS; BIOMEMBRANES; ELECTROPERTURBATION; PULSE POWER SYSTEMS;

PULSE GENERATORS;

EID: 34547742547     PISSN: 10709878     EISSN: None     Source Type: Journal    
DOI: 10.1109/TDEI.2007.4286518     Document Type: Conference Paper

References (9)

1. P. T. Vernier, Y. Sun, J. Wang, M. M. Thu, E. B. Garon., M. Valderrabano, L. Marcu, H. P. Koeffler, and M. A. Gundersen, "Nanoelectropulse intracellular perturbation and electropermeabilization technology: phospholipid translocation, calcium bursts, chromatin rearrangement, cardiomyocyte activation, and tumor cell sensitivity", 27th Annual Intern. Conf. IEEE Engineering in Medicine and Biology Society, Shanghai, pp. 5850-5853, 2005.
2. K. H. Schoenbach, S. J. Beebe, and E. S. Buescher, "Intracellular Effect of Ultrashort Electrical Pulses", Bioelectromagnetics, Vol. 22, pp. 440448, 2001.
3. P.T. Vernier, Y. Sun, L. Marcu, S. Salemi, C. M. Craft, and M. A. Gundersen, "Calcium bursts induced by nanosecond electric pulses", Biochemical and Biophyiscal Research Communications, Vol. 310, pp. 286-295, 2003.
4. A. Kuthi, M. Behrend, P. Thomas Vernier, and M. A. Gundersen, "Nanosecond Pulse Generator Using Fast Recovery Diodes for Cell Electromanipulation", IEEE Trans. Plasma Sci., Vol. 33, pp. 1192-1197, 2005.
5. E. S. Fulkerson and R. Booth, "Design of Reliable High Voltage Avalanche Transistor Pulsers", IEEE 21st Intern. Power Modulator Symposium, p. 101-103, 1994.
6. th Midwest Symposium on Circuits and Systems, Vol. 1, No. 3-6, pp. 148-151, 1997.
7. M.R. Behrend, A. Kuthi and M.A. Gundersen, "DC to 1 Gigahertz multikilovolt voltage probe", 26th Intern Power Modulator Symposium and High Voltage Workshop, pp. 341-343, 2004.
8. Y. Sun, P. T. Vernier, M. Behrend, L. Marcu, and M. A. Gundersen, "Electrode microchamber for noninvasive perturbation of mammalian cells with nanosecond pulsed electric fields", IEEE Trans. Nanobiosci., Vol. 4, pp.277-283, 2005.
9. M. Behrend, A. Kuthi, X. Gu, P. T. Vernier, L. Marcu, C. M. Craft and M. A. Gundersen, "Pulse Generators for pulsed electric field exposure of biological cells and tissues", IEEE Trans. Dielectr. Electr. Insul., Vol. 10, pp. 820-825, 2003.