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Volumn 55, Issue 15, 2007, Pages 6018-6026

Identification of cytotoxic constituents of Narthecium ossifragum using bioassay-guided fractionation

Author keywords

Alveld; Cytotoxicity; Furanones; Hepatotoxin; Liliaceae; Narthecium spp.; Nephrotoxin; Neutral red; Saponins

Indexed keywords

SAPONIN;

EID: 34547732037     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf070776k     Document Type: Article
Times cited : (6)

References (31)
  • 1
    • 34547725807 scopus 로고    scopus 로고
    • Stabursvik, A. A phytochemical study of Narthecium ossifragum (L.) Huds. Doctoral Thesis, Norges Tekniske Vitenskapsakademi, Trondheim, Noway, 1959.
    • Stabursvik, A. A phytochemical study of Narthecium ossifragum (L.) Huds. Doctoral Thesis, Norges Tekniske Vitenskapsakademi, Trondheim, Noway, 1959.
  • 2
    • 0001003689 scopus 로고
    • Undersøkelser over alveldsykens etiologi (Etiological studies on "alveld" - a disease involving photosensitization and icterus in lambs)
    • Ender, F. Undersøkelser over alveldsykens etiologi (Etiological studies on "alveld" - a disease involving photosensitization and icterus in lambs). Nordisk Vet.-Med. 1955, 7, 329-377.
    • (1955) Nordisk Vet.-Med , vol.7 , pp. 329-377
    • Ender, F.1
  • 3
    • 0042094978 scopus 로고    scopus 로고
    • Plant-associated hepatogenous photosensitization diseases
    • Natural and Selected Synthetic Toxins: Biological Implications; Gaffield, W, Tu, A. T, Eds, American Chemical Society: Washington, DC
    • Flåøyen, A. Plant-associated hepatogenous photosensitization diseases. In Natural and Selected Synthetic Toxins: Biological Implications; Gaffield, W., Tu, A. T., Eds.; ACS Symposium Series 745; American Chemical Society: Washington, DC, 2000; pp 204-219.
    • (2000) ACS Symposium Series , vol.745 , pp. 204-219
    • Flåøyen, A.1
  • 5
    • 0026297552 scopus 로고
    • Failure to induce toxicity in lambs by administering saponins from Narthecium ossifragum
    • Flåøyen, A.; Hjorth, T. H.; Grønstøl, H.; Karlsen, J. Failure to induce toxicity in lambs by administering saponins from Narthecium ossifragum. Vet. Res. Commun. 1991, 15, 483-487.
    • (1991) Vet. Res. Commun , vol.15 , pp. 483-487
    • Flåøyen, A.1    Hjorth, T.H.2    Grønstøl, H.3    Karlsen, J.4
  • 6
    • 1842844628 scopus 로고    scopus 로고
    • Accumulation of sapogenin conjugates and histological changes in the liver and kidneys of lambs suffering from alveld, a hepatogenous photosensitization disease of sheep grazing Narthecium ossifragum
    • Wisløff, H.; Wilkins, A. L.; Scheie, E.; Flåøyen, A. Accumulation of sapogenin conjugates and histological changes in the liver and kidneys of lambs suffering from alveld, a hepatogenous photosensitization disease of sheep grazing Narthecium ossifragum. Vet. Res. Commun. 2002, 26, 381-396.
    • (2002) Vet. Res. Commun , vol.26 , pp. 381-396
    • Wisløff, H.1    Wilkins, A.L.2    Scheie, E.3    Flåøyen, A.4
  • 7
    • 0033391027 scopus 로고    scopus 로고
    • Langseth, W.; Torgersen, T.; Kolsaker, P.; Romming, C.; Jantsch, T. G.; Mantle, P. G.; Pearce, J.; Gibson, S. E.; Goicochea, M. G.; Flåø yen, A. Isolation and characterization of 3-methoxy-2(5H)-furanone as the principal nephrotoxin from Narthecium ossifragum (L.) Huds. Nat. Tax. 1999, 7, 111-118.
    • Langseth, W.; Torgersen, T.; Kolsaker, P.; Romming, C.; Jantsch, T. G.; Mantle, P. G.; Pearce, J.; Gibson, S. E.; Goicochea, M. G.; Flåø yen, A. Isolation and characterization of 3-methoxy-2(5H)-furanone as the principal nephrotoxin from Narthecium ossifragum (L.) Huds. Nat. Tax. 1999, 7, 111-118.
  • 8
    • 0037810571 scopus 로고    scopus 로고
    • Narthecium ossifragum (L.) Huds. causes kidney damage in goats: Morphologic and functional effects
    • Wisløff, H.; Flåøyen, A.; Ottesen, N.; Hovig, T. Narthecium ossifragum (L.) Huds. causes kidney damage in goats: morphologic and functional effects. Vet. Pathol. 2003, 40, 317-327.
    • (2003) Vet. Pathol , vol.40 , pp. 317-327
    • Wisløff, H.1    Flåøyen, A.2    Ottesen, N.3    Hovig, T.4
  • 9
    • 33846581346 scopus 로고    scopus 로고
    • Wisløff, H.; Gharehnia, B.; Flåøyen, A.; Andersen, K. J. Effects of 3-methoxy-2(5H)-furanone-containing extracts from Narthecium ossifragum (L.) Huds. on renal tubular cells in vitro. Toxicon 2007, 49, 368-377.
    • Wisløff, H.; Gharehnia, B.; Flåøyen, A.; Andersen, K. J. Effects of 3-methoxy-2(5H)-furanone-containing extracts from Narthecium ossifragum (L.) Huds. on renal tubular cells in vitro. Toxicon 2007, 49, 368-377.
  • 10
    • 0029056944 scopus 로고
    • Structures of toxic steroidal saponins from Narthecium asiaticum Maxim
    • Inoue, T.; Mimaki, Y.; Sashida, Y.; Kobayashi, M. Structures of toxic steroidal saponins from Narthecium asiaticum Maxim. Chem. Pharm. Bull. 1995, 43, 1162-1166.
    • (1995) Chem. Pharm. Bull , vol.43 , pp. 1162-1166
    • Inoue, T.1    Mimaki, Y.2    Sashida, Y.3    Kobayashi, M.4
  • 11
    • 33846621664 scopus 로고    scopus 로고
    • Stabursvik, A.; Holen, B. Saxosterol, a new dihydroxy cholesterol from Narthecium ossifragum. Phytochemistry 1988, 27, 1893-1895.
    • Stabursvik, A.; Holen, B. Saxosterol, a new dihydroxy cholesterol from Narthecium ossifragum. Phytochemistry 1988, 27, 1893-1895.
  • 12
    • 0015172730 scopus 로고
    • Über Narthecid A und B, zwei diastereomere Lacton-Glucoside und ihr antibiotisch wirksames Aglykon aus Beinbrech (Narthecium ossifragum Huds.)
    • Tschesche, R.; Hoppe, H.-J. Über Narthecid A und B, zwei diastereomere Lacton-Glucoside und ihr antibiotisch wirksames Aglykon aus Beinbrech (Narthecium ossifragum Huds.). Chem. Ber. 1971, 104, 3573-3581.
    • (1971) Chem. Ber , vol.104 , pp. 3573-3581
    • Tschesche, R.1    Hoppe, H.-J.2
  • 13
    • 34547781329 scopus 로고
    • Narthecium Huds
    • Det Norske Samlaget: Oslo, Norway
    • Lid, J. Narthecium Huds. In Norsk og Svensk Flora; Det Norske Samlaget: Oslo, Norway, 1974.
    • (1974) Norsk og Svensk Flora
    • Lid, J.1
  • 14
    • 0000926399 scopus 로고
    • GC-MS method for analysis of steroidal sapogenins in plant and animal samples associated with ovine photosensitisation
    • Colegate, S. M, Dorling, P. R, Eds, CAB International: Wallingford, U.K
    • Wilkins, A. L.; Miles, C. O.; Smith, B. L.; Meagher, L. P.; Ede, R. M. GC-MS method for analysis of steroidal sapogenins in plant and animal samples associated with ovine photosensitisation, In Plant-Associated Toxins. Agricultural, Phytochemical and Ecological Aspects; Colegate, S. M., Dorling, P. R., Eds.; CAB International: Wallingford, U.K., 1994.
    • (1994) Plant-Associated Toxins. Agricultural, Phytochemical and Ecological Aspects
    • Wilkins, A.L.1    Miles, C.O.2    Smith, B.L.3    Meagher, L.P.4    Ede, R.M.5
  • 15
    • 0036184576 scopus 로고    scopus 로고
    • Ruminal metabolism in sheep of saponins from Yucca schidigera
    • Flåøyen, A.; Wilkins, A. L.; Sandvik, M. Ruminal metabolism in sheep of saponins from Yucca schidigera. Vet. Res. Commun. 2002, 26, 159-169.
    • (2002) Vet. Res. Commun , vol.26 , pp. 159-169
    • Flåøyen, A.1    Wilkins, A.L.2    Sandvik, M.3
  • 16
  • 17
    • 33747816149 scopus 로고    scopus 로고
    • Toxicophores: Investigations in drug safety
    • Williams, D. P. Toxicophores: investigations in drug safety. Toxicology 2006, 226, 3-13.
    • (2006) Toxicology , vol.226 , pp. 3-13
    • Williams, D.P.1
  • 19
    • 33646379112 scopus 로고    scopus 로고
    • Anti-inflammatory and anti-arthritic effects of Yucca schidigera: A review
    • Cheeke, P. R. Anti-inflammatory and anti-arthritic effects of Yucca schidigera: a review. J. Inflamm. 2006, 3, 1-17.
    • (2006) J. Inflamm , vol.3 , pp. 1-17
    • Cheeke, P.R.1
  • 21
    • 23844507538 scopus 로고    scopus 로고
    • Identification and quantification of steroidal saponins in Polygonatum species by HPLC/ESI/MS
    • Ahn, M. J.; Kim, J. Identification and quantification of steroidal saponins in Polygonatum species by HPLC/ESI/MS. Arch. Pharm. Res. 2005, 28, 592-597.
    • (2005) Arch. Pharm. Res , vol.28 , pp. 592-597
    • Ahn, M.J.1    Kim, J.2
  • 22
    • 13444272213 scopus 로고    scopus 로고
    • Characteristic fragmentation behavior of some glucuronide-type triterpenoid saponins using electrospray ionization tandem mass spectrometry
    • Li, B.; Abliz, Z.; Fu, G. M.; Tang, M. J.; Yu, S. S. Characteristic fragmentation behavior of some glucuronide-type triterpenoid saponins using electrospray ionization tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2005, 19, 381-390.
    • (2005) Rapid Commun. Mass Spectrom , vol.19 , pp. 381-390
    • Li, B.1    Abliz, Z.2    Fu, G.M.3    Tang, M.J.4    Yu, S.S.5
  • 23
    • 31544458922 scopus 로고    scopus 로고
    • Esi-Qqtof-Ms/Ms and Apci-It-Ms/Ms analysis of steroid saponins from the rhizomes of Dioscorea panthaica
    • Li, R.; Zhou, Y.; Wu, Z. J.; Ding, L. S. Esi-Qqtof-Ms/Ms and Apci-It-Ms/Ms analysis of steroid saponins from the rhizomes of Dioscorea panthaica. J. Mass Spectrom. 2006, 41, 1-22.
    • (2006) J. Mass Spectrom , vol.41 , pp. 1-22
    • Li, R.1    Zhou, Y.2    Wu, Z.J.3    Ding, L.S.4
  • 24
    • 0035319698 scopus 로고    scopus 로고
    • Ovine metabolism of saponins: Evaluation of a method for estimating the ovine uptake of steroidal saponins from Narthecium ossifragum
    • Flåøyen, A.; Wilkins, A. L.; Deng, D.; Brekke, T. Ovine metabolism of saponins: evaluation of a method for estimating the ovine uptake of steroidal saponins from Narthecium ossifragum. Vet. Res. Commun. 2001, 25.
    • (2001) Vet. Res. Commun , vol.25
    • Flåøyen, A.1    Wilkins, A.L.2    Deng, D.3    Brekke, T.4
  • 25
    • 0019743447 scopus 로고
    • Alveld-producing saponins I. Chemical studies
    • Čeh, L.; Hauge, J. G. Alveld-producing saponins I. Chemical studies. Acta Vet. Scand. 1981, 22, 391-402.
    • (1981) Acta Vet. Scand , vol.22 , pp. 391-402
    • Čeh, L.1    Hauge, J.G.2
  • 26
    • 0036956250 scopus 로고    scopus 로고
    • The biological action of saponins in animal systems: A review
    • Francis, G.; Kerem, Z.; Makkar, H. P. S.; Becker, K. The biological action of saponins in animal systems: a review. Br. J. Nutr. 2002, 88, 587-605.
    • (2002) Br. J. Nutr , vol.88 , pp. 587-605
    • Francis, G.1    Kerem, Z.2    Makkar, H.P.S.3    Becker, K.4
  • 27
    • 37049052069 scopus 로고
    • Action of saponin on biological membranes
    • Glauert, A. M.; Dingle, J. T.; Lucy, J. A. Action of saponin on biological membranes. Nature 1967, 196, 953-955.
    • (1967) Nature , vol.196 , pp. 953-955
    • Glauert, A.M.1    Dingle, J.T.2    Lucy, J.A.3
  • 28
    • 0030752867 scopus 로고    scopus 로고
    • Metabolism of saponins from Narthecium ossifragum - a plant implicated in the aetiology of alveld, a hepatogenous photosensitization of sheep
    • Flåøyen, A.; Wilkins, A. L. Metabolism of saponins from Narthecium ossifragum - a plant implicated in the aetiology of alveld, a hepatogenous photosensitization of sheep. Vet. Res. Commun. 1997, 21, 335-345.
    • (1997) Vet. Res. Commun , vol.21 , pp. 335-345
    • Flåøyen, A.1    Wilkins, A.L.2
  • 29
    • 0026132498 scopus 로고
    • Photosensitivity in South Africa. VI. The experimental induction of geeldikkop in sheep with crude steroidal saponins from Tribulus terrestris
    • Kellerman, T. S.; Erasmus, G. L.; Coetzer, J. A.; Brown, J. M.; Maartens, B. P. Photosensitivity in South Africa. VI. The experimental induction of geeldikkop in sheep with crude steroidal saponins from Tribulus terrestris. Onderstepoort J. Vet. Res. 1991, 58, 47-53.
    • (1991) Onderstepoort J. Vet. Res , vol.58 , pp. 47-53
    • Kellerman, T.S.1    Erasmus, G.L.2    Coetzer, J.A.3    Brown, J.M.4    Maartens, B.P.5
  • 30
    • 0009923038 scopus 로고
    • Lecheguilla (Agave lecheguilla) poisoning in sheep, goats, and laboratory animals
    • Mathews, F. P. Lecheguilla (Agave lecheguilla) poisoning in sheep, goats, and laboratory animals. Tex. Agric. Exp. Stn. Bull. 1937, No. 554, 5-36.
    • (1937) Tex. Agric. Exp. Stn. Bull , Issue.554 , pp. 5-36
    • Mathews, F.P.1
  • 31
    • 0001060926 scopus 로고
    • Identification of insoluble salts of the β-D-glucuronides of episarsasapogenin and epismilagenin in the bile of lambs with alveld, and examination of Narthecium ossifragum, Tribulus terrestris, and Panicum miliaceum for sapogenins
    • Miles, C. O.; Wilkins, A. L.; Munday, S. C.; Flåoyen, A.; Holland, P. T.; Smith, B. L. Identification of insoluble salts of the β-D-glucuronides of episarsasapogenin and epismilagenin in the bile of lambs with alveld, and examination of Narthecium ossifragum, Tribulus terrestris, and Panicum miliaceum for sapogenins. J. Agric. Food Chem. 1993, 41, 914-917.
    • (1993) J. Agric. Food Chem , vol.41 , pp. 914-917
    • Miles, C.O.1    Wilkins, A.L.2    Munday, S.C.3    Flåoyen, A.4    Holland, P.T.5    Smith, B.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.