Review of recent HSV recurrent-infection treatment studies

Herpes

Volumn 14, Issue 1, 2007, Pages 23-26

  Patel, Raj ^a,d   Stanberry, Lawrence ^b   Whitley, Richard J ^c  

^a UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d ROYAL SOUTH HANTS HOSPITAL   (United Kingdom)

Author keywords

Antiviral therapy; Genital herpes; Herpes simplex virus; HSV shedding; Patient initiated episodic therapy; Suppressive therapy

Indexed keywords

ACICLOVIR; FAMCICLOVIR; PLACEBO; VALACICLOVIR;

ANTIVIRAL THERAPY; CLINICAL TRIAL; CONFERENCE PAPER; DISEASE COURSE; DOSE RESPONSE; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; DRUG TOLERABILITY; HERPES LABIALIS; HERPES SIMPLEX; HERPES SIMPLEX VIRUS; HUMAN; PRIORITY JOURNAL; TREATMENT INDICATION; TREATMENT OUTCOME;

ANTIVIRAL AGENTS; HERPES SIMPLEX; HUMANS; RECURRENCE; SIMPLEXVIRUS; TIME FACTORS; TREATMENT OUTCOME; VIRAL LOAD; VIRUS SHEDDING;

HERPES; SIMPLEXVIRUS;

EID: 34547730640     PISSN: 09697667     EISSN: 14701537     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (16)

1. Spruance SL, Overall JC, Jr, Kern ER, Krueger GG, Pliam V, Miller W. The natural history of recurrent herpes simplex labialis: implications for antiviral therapy. N Engl J Med 1977;297:69-75.
2. Brown ZA, Kern ER, Spruance SL, Overall JC, Jr. Clinical and virological course of herpes simplex genitalis. West J Med 1979;130:414-421.
3. Spruance SL, Bodsworth N, Resnick H, Conant M, Oeuvray C, Gao J et al. Single-dose, patient-initiated famciclovir: a randomized, double-blind, placebo-controlled trial for episodic treatment of herpes labialis. J Am Acad Dermatol 2006;55:47-53.
4. Corey L, Adams HG, Brown ZA, Holmes KK. Genital herpes simplex virus infections: clinical manifestations, course, and complications. Ann Intern Med. 1983;98:958-972.
5. Aoki FY, Tyring S, Diaz-Mitoma F, Gross G, Gao J, Hamed K. Single-day, patient-initiated famciclovir therapy for recurrent genital herpes: a randomized, double-blind, placebo-controlled trial. Clin Infect Dis 2006;42:8-13.
6. Ruhnek-Forsbeck M, Sandstrom E, Andersson B, Eriksson G, Hersle K, Lovhagen GB et al. Treatment of recurrent genital herpes simplex infections with oral acyclovir. J Antimicroh Chemother 1985;16:621-628.
7. Douglas JM, Critchlow C, Benedetti J, Mertz GJ, Connor JD, Hintz MA et al. A double-blind study of oral acyclovir for suppression of recurrences of genital herpes simplex virus infection. N Engl J Med 1984;310:1551-1556.
8. Mertz GJ, Jones CC, Mills J, Fife KH, Lemon SM, Stapleton JT et al. Long-term acyclovir suppression of frequently recurring genital herpes simplex virus infection. A multicenter double-blind trial. JAMA 1988;260:201-206.
9. Straus SE, Takiff HE, Seidlin M, Bachrach S, Lininger L, DiGiovanna JJ et al. Suppression of frequently recurring genital herpes. A placebo-controlled double-blind trial of oral acyclovir. N Engl J Med 1984;310:1545-1550.
10. Kaplowitz LG, Baker D, Gelb L, Blythe J, Hale R, Frost P et al. Prolonged continuous acyclovir treatment of normal adults with frequently recurring genital herpes simplex virus infection. The Acyclovir Study Group. JAMA 1991;265:747-751.
11. Patel R, Bodsworth NJ, Woolley P, Peters B, Vejlsgaard G, Saari S et al. Valaciclovir for the suppression of recurrent genital HSV infection: a placebo controlled study of once daily therapy. International Valaciclovir HSV Study Group. Genitourin Med 1997;73:105-109.
12. Wald A, Zeh J, Barnum G, Davis LG, Corey L. Suppression of subclinical shedding of herpes simplex virus type 2 with acyclovir. Ann Intern Med 1996;124:8-15.
13. Corey L, Wald A, Patel R, Sacks SL, Tyring SK, Warren T et al. Valacyclovir HSV Transmission Study Group. Once-daily valacyclovir to reduce the risk of transmission of genital herpes. N Engl J Med 2004;350:11-20.
14. Griffiths P. Is viral shedding a surrogate marker for transmission of genital herpes? Herpes 2004;11:66-69.
15. Wald A, Selke S, Warren T, Aoki FY, Sacks S, Diaz-Mitoma F et al. Comparative efficacy of famciclovir and valacyclovir for suppression of recurrent genital herpes and viral shedding. Sex Transm Dis 2006;33:529-533.
16. Leone P, Warren T, Hamed K, Fife K, Wald A. Famciclovir reduces viral mucosal shedding in HSV-seropositive persons. Sex Transm Dis 2007 (in press).