Molecular basis for acceptor substrate specificity of the human β1,3-glucuronosyltransferases GlcAT-I and GlcAT-P involved in glycosaminoglycan and HNK-1 carbohydrate epitope biosynthesis, respectively

Glycobiology

Volumn 17, Issue 8, 2007, Pages 857-867

  Fondeur Gelinotte, Magali ^a   Lattard, Virginie ^a   Gulberti, Sandrine ^a   Oriol, Rafael ^c   Mulliert, Guillermo ^b   Coughtrie, Michael W H ^d   Magdalou, Jacques ^a   Netter, Patrick ^a   Ouzzine, Mohamed ^a   Fournel Gigleux, Sylvie ^a  

^a Biopôle de l Université de Lorraine   (France)

^b Nancy University CNRS   (France)

^c INSERM   (France)

^d UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

1,3 glucuronosyltransferases; Acceptor substrate specificity; Glycosaminoglycans; Kinetics; Site directed mutagenesis

Indexed keywords

ARGININE; ASPARTIC ACID; EPITOPE; GALACTOSE BETA 1,3 GLUCURONOSYLTRANSFERASE I; GALACTOSE BETA 1,3 GLUCURONOSYLTRANSFERASE P; GLUCURONOSYLTRANSFERASE; GLUTAMIC ACID; GLYCOSAMINOGLYCAN; PHENYLALANINE; PROTEOGLYCAN; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARBOHYDRATE SYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; GENE MUTATION; HYDROGEN BOND; MOLECULAR MECHANICS; MOLECULAR MODEL; MOLECULAR RECOGNITION; NONHUMAN; PICHIA PASTORIS; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; ANTIGENS, CD57; BINDING SITES; EPITOPES; GLUCURONOSYLTRANSFERASE; GLYCOSAMINOGLYCANS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; SUBSTRATE SPECIFICITY;

EID: 34547728713     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cwm055     Document Type: Article

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