Implications of diphenhydramine single-dose unintended ingestions in young children

Pediatric Emergency Care

Volumn 23, Issue 7, 2007, Pages 465-468

  Stojanovski, Sasko D ^a,b   Baker, S David ^c,d   Casavant, Marcel J ^a,c,d,e   Hayes, John R ^b,d   Robinson, Renee F ^a,b,c,d,e   Nahata, Milap C ^a,b,d,e  

^a OHIO STATE UNIVERSITY   (United States)

^b THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

^c Central Ohio Poison Center   (United States)

^d NATIONWIDE CHILDREN S HOSPITAL   (United States)

^e THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Benadryl; Diphenhydramine hydrochloride; Overdose exposures

Indexed keywords

DIPHENHYDRAMINE;

ADVERSE OUTCOME; ARTICLE; CLINICAL EVALUATION; DISEASE SEVERITY; FEMALE; HEALTH SURVEY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; SINGLE DRUG DOSE; STATISTICAL ANALYSIS; SYMPTOM;

AGE DISTRIBUTION; ANTI-ALLERGIC AGENTS; CHILD; CHILD, PRESCHOOL; DIPHENHYDRAMINE; FEMALE; HUMANS; INFANT; MALE; MORTALITY; POISON CONTROL CENTERS; POPULATION SURVEILLANCE; SEVERITY OF ILLNESS INDEX;

EID: 34547700234     PISSN: 07495161     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pec.0000280510.75418.31     Document Type: Article

References (25)

1. Top 50 OTC brands ranked by 2003 dollar sales. Drug Store News. 2004;26:42.
2. Litovitz TL, Klein-Schwartz W, White S, et al. 2000 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med. 2001;19:337-395.
3. Litovitz TL, Klein-Schwartz W, White S, et al. 2001 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med. 2002;20:391-438.
4. Hestand HE, Teske DW. Diphenhydramine hydrochloride intoxication. J Pediatr. 1977;90:1017-1018.
5. Chien C, Marriott JL, Ashby K, et al. Unintentional ingestion of over the counter medications in children less than 5 years old. J Paediatr Child Health. 2003;39:264-269.
6. Michael JB, Sztajnkrycer MD. Deadly pediatric poisons: nine common agents that kill at low doses. Emerg Med Clin North Am. 2004;22:1019-1050. (abstract).
7. Kearney TE, Hiatt PH, Machado L, et al. Validating send-in guidelines: factors influencing triage decisions for pediatrics diphenhydramine ingestions. J Toxicol Clin Toxicol. 2004;42:815-816. (abstract).
8. Reisdorf J, Bottema C, Anderson D. Characteristics pediatric exposures to diphenhydramine. J Toxicol Clin Toxicol. 2002;40:616. (abstract).
9. Zavitz M, Lindsay C, McGuigan MA. Acute diphenhydramine ingestions in children. Vet Hum Toxicol. 1989;31:349.
10. Reyes-Jagang A, Wenzl JE. Antihistamine toxicity in children. Clin Pediatr. 1969;8:297-299.
11. Duerfeldt TH. Acute Benadryl poisoning. Nothwest Med. 1947;46:781-782.
12. Reichelderfer TE, Livingston S, Auld RM. Treatment of acute Benadryl (diphenhydramine hydrochloride) intoxication with severe central nervous system changes and recovery. J Pediatr. 1955;46:303-307.
13. Starr MP, Rankin RM. Acute Benadryl intoxication: case report. Northwest Med. 1948;88:195.
14. Judge DJ, Dumars KW. Diphenhydramine (Benadryl) and tripelennamine (Pyribenzamine) intoxication in children. Am J Dis Child. 1953;85:545-550.
15. Wyngaarden JB, Seevers MH. The toxic effects of antihistaminic drugs. JAMA. 1951;145:277-282.
16. Huxtable RF, Landwirth J. Diphenhydramine poisoning treated by exchange transfusion. Am J Dis Child. 1963;106:496-500.
17. Stucka KR, Mycyk MB, Leikin JB, et al. Rhabdomyolysis associated with unintentional antihistamine overdose in a child. Pediatr Emerg Care. 2003;19:25-26.
18. Guard HL. Benadryl intoxication: case report. Med Bull U S Army Eur Command Med Div. 1952;9:17-20.
19. Goetz CM, Lopez G, Dean BS, et al. Accidental childhood death from diphenhydramine overdosage. Am J Emerg Med. 1990;8:321-322.
20. Davis JH, Hunt HH. Accidental Benadryl poisoning: report of a fatal case. J Pediatr. 1949;34:358-361.
21. Lindsay CA, Williams GD, Levin DL. Fatal adult respiratory distress syndrome after diphenhydramine toxicity in a child: a case report. Crit Care Med. 1995;23:777-781.
22. Aaron FE. A case of acute diphenhydramine hydrochloride poisoning. BMJ. 1953;2:24.
23. Baker AM, Johnson DG, Levisky JA, et al. Fatal diphenhydramine intoxication in infants. J Forensic Sci. 2003;48:1-4.
24. Radovanovic D, Meier PJ, Guirguis M, et al. Dose-dependent toxicity of diphenhydramine overdose. Hum Exp Toxicol. 2000;19:489-495.
25. Scharman EJ, Erdman AR, Wax PM, et al. Diphenhydramine and dimenhydrinate poisoning: an evidence-based consensus guideline for out-of-hospital management. Available at: http://www.aapcc.org/FinalizedPMGdlns/ finalizedPMGuidelines.htm. Accessed September 2005.