Amperometric responses of CYP2D6 drug metabolism nanobiosensor for sertraline: A selective serotonin reuptake inhibitor

IET Nanobiotechnology

Volumn 1, Issue 4, 2007, Pages 62-67

  Iwuoha, E ^a   Ngece, R ^a   Klink, M ^a   Baker, P ^a  

^a UNIVERSITY OF THE WESTERN CAPE   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

CONCENTRATION (PROCESS); DRUG PRODUCTS; ENZYME INHIBITION; GOLD; METABOLISM; PATIENT TREATMENT; PLASMA (HUMAN);

AMPEROMETRIC RESPONSES; BIOTRANSFORMATION; NANOBIOSENSORS; SEROTONIN REUPTAKE INHIBITORS;

BIOSENSORS;

CYTOCHROME P450 2D6; IMMOBILIZED ENZYME; SEROTONIN UPTAKE INHIBITOR; SERTRALINE;

ARTICLE; BLOOD ANALYSIS; CHEMISTRY; ELECTROCHEMISTRY; EQUIPMENT; EQUIPMENT DESIGN; EVALUATION; GENETIC PROCEDURES; INSTRUMENTATION; METHODOLOGY; NANOTECHNOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

BIOSENSING TECHNIQUES; BLOOD CHEMICAL ANALYSIS; CYTOCHROME P-450 CYP2D6; ELECTROCHEMISTRY; ENZYMES, IMMOBILIZED; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; NANOTECHNOLOGY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SEROTONIN UPTAKE INHIBITORS; SERTRALINE;

EID: 34547699369     PISSN: 17518741     EISSN: None     Source Type: Journal    
DOI: 10.1049/iet-nbt:20070005     Document Type: Article

References (14)

1. Mandrioli, R., and Ferarri, S.: ' HPLC analysis of the second-generation antidepressant sertraline and its main metabolite N-desmethylsertraline in human plasma ', J. Chromatogr. B, 2006, 836, p. 116-119
2. Kobayashi, K., Ishizuka, T., Shimada, N., Yoshimura, Y., Kamijima, K., and Chiba, K.: ' Sertraline N-demethylation is catalyzed by multiple isoforms of human cytochrome P-450 in vitro ', Drug Metabolism and Disposition, 1999, 27, p. 763-766
3. Heime, C., and Hartter, S.: ' Pharmacokinetics of selective serotonin reuptake inhibitors ', Pharmacol. Therap., 2000, 85, p. 19-20
4. Adeyoju, O.O.: ' Development of horseradish peroxidase and tyrosinase-based organic-phase biosensors ', 1995, PhD, Dublin City University
5. Brennan, S.: ' Comparative studies of the organic and aqueous phase reactivities of a phathalic anhydride-modified hydrogen peroxidase biosensor ', 1996, PhD, Dublin City University
6. Bistolas, N., and Scheller, F.W.: ' Cytochrome P450 biosensors - a review ', Biosens. Bioelectron., 2005, 20, p. 2414 0956-5663
7. Brahim, S., and Guiseppi-Elie, A.: ' Chemical and biological sensors based on electrochemical detection using conducting electroactive polymers ', Microchim. Acta, 2003, 143, p. 123-137
8. Ngece, F.: ' Development of an electroanalytical sensor system for the determination of phenols ', 2004, Honour, University of the Western Cape
9. Iwuoha, E., and Smyth, M.: ' Reactivites of organic phase biosensors 2. The amperometric behaviour of horseradish peroxidase immobilized on a platinum electrode modified with an electrosynthetic polyaniline film ', Biosens. Bioelectron, 1997, 12, p. 749-761 0956-5663
10. Iwuoha, E.I., and Kane, S.: ' Reactivities of organic phase biosensors 3: electrochemical study of cytochrome P450CAM immobilized in a methyltriethoxysilane sol-gel ', Electroanalysis, 2000, 12, p. 980-986
11. Mathebe, N.G.R., Morrin, A., and Iwuoha, E.I.: ' Electrochemistry and scanning electro microscopy of polyaniline/peroxide-based biosensor ', Talanta, 2004, 64, p. 115-120
12. 2D6 (CYP2D6) bioelectrode for Fluoxetine ', Anal. Lett., 2004, 37, p. 943-956
13. Iwuoha, E., and Williams, A.: ' Novel electron transfer mediators for amperometric bioelectrodes: introduction of methylsquarate and phenylsquarate ', Electroanalysis, 2002, 14, p. 1-8
14. Heym, J., and Koe, B.K.: ' Pharmacology of sertraline: a review ', J. Clin. Psychiatry, 1988, 49, p. 40-45