Linezolid-related pancytopenia in organ-transplant patients: Report of two cases

Infection

Volumn 35, Issue 4, 2007, Pages 275-277

  Faguer, S ^a   Kamar, N ^a   Fillola, G ^a   Guitard, J ^a   Rostaing, L ^a,b  

^a CHU RANGUEIL   (France)

^b Service de Néphrologie Transplantation d'Organes   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMLODIPINE; ATENOLOL; CASPOFUNGIN; COTRIMOXAZOLE; CYCLOSPORIN A; FERRITIN; FUROSEMIDE; HEMOGLOBIN; HEPARIN; INSULIN; LINEZOLID; METRONIDAZOLE; OMEPRAZOLE; PREDNISONE; PYRIDOXINE; RECOMBINANT ERYTHROPOIETIN; REPAGLINIDE; STEROID; TACROLIMUS; URAPIDIL; VALGANCICLOVIR;

ADULT; ANEMIA; ANTIBIOTIC PROPHYLAXIS; ARTICLE; BONE MARROW TOXICITY; CASE REPORT; DECUBITUS; DRUG CONTRAINDICATION; DRUG WITHDRAWAL; FEMALE; GRAM POSITIVE COCCI; HEPATITIS C; HUMAN; IMMUNE DEFICIENCY; KIDNEY TRANSPLANTATION; LIVER CIRRHOSIS; LIVER TRANSPLANTATION; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NEUTROPENIA; ORGAN TRANSPLANTATION; PANCYTOPENIA; STAPHYLOCOCCUS INFECTION; THROMBOCYTOPENIA; URINARY TRACT MALFORMATION;

ACETAMIDES; ADULT; ANTI-INFECTIVE AGENTS; FEMALE; HUMANS; MALE; MIDDLE AGED; OXAZOLIDINONES; PANCYTOPENIA; PERITONITIS; PRESSURE ULCER; TRANSPLANTS;

EID: 34547697220     PISSN: 03008126     EISSN: None     Source Type: Journal    
DOI: 10.1007/s15010-007-6197-6     Document Type: Article

References (12)

1. Zyvox (linezolid) [package insert]. Kalamazoo, MI: Pharmacia and Upjohn Company, 2001.
2. Green SL, Maddox JC, Huttenbach ED: Linezolid and reversible myelosuppression JAMA 2001; 285: 1291.
3. Halpern M: Linezolid-induced pancytopenia Clin Infect Dis 2002; 35: 347-348.
4. Nimeiri HS, Nemiary D: Challenges with linezolid therapy and reversible pancytopenia Ann Hematol 2003; 82: 53.
5. Attassi K, Hershberger, Alam R, et al.: Thrombocytopenia associated with linezolid therapy. Clin Infect Dis 2002; 34: 695-698.
6. Orrick JJ, Johns T, Janelle J, et al.: Thrombocytopenia secondary to linezolid administration: what is the risk? Clin Infect Dis 2002; 35: 348-349.
7. Monson T, Schichman SA, Zent CS: Linezolid-induced pure red blood cell aplasia. Clin Infect Dis 2002; 35: E29-E31.
8. Hachem RY, Hicks K, Huen A, Raad I: Myelosuppression and serotonin syndrome associated with concurrent use of linezolid and selective serotonin reuptake inhibitors in bone marrow transplant recipients. Clin Infect Dis 2003; 37: e8-e11.
9. El-khoury J, Fishman JA: Linezolid in the treatment of vancomycin-resistant Enterococcus faecium in solid organ transplant recipients: report of a multicenter compassionate-use trial. Transpl Infect Dis 2003; 5: 121-125.
10. Wu VC, Wang YT, Wang CY: High frequency of linezolid-associated thrombocytopenia and anemia among patients with end-stage renal disease Clin Infect Dis 2006; 42: 66-72.
11. Dawson MA, Davis A, Elliott P, Cole-Sinclair M: Linezolid-induced dyserythropoiesis: chloramphenicol toxicity revisited. Intern Med J 2005; 35: 626-628.
12. Spellberg B, Yoo T, Bayer AS: Reversal of linezolid-associated cytopenias, but not peripheral neuropathy, by administration of vitamin B6. J Antimicrob Chemother 2004; 54: 832-835.