Florid histiocytic hemophagocytosis following therapy with long acting G-CSF (pegfilgrastim)

American Journal of Hematology

Volumn 82, Issue 8, 2007, Pages 753-757

  Glasser, Lewis ^a   LeGolvan, Mark ^a   Horwitz, Harold M ^b  

^a RHODE ISLAND HOSPITAL   (United States)

^b MIRIAM HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CREATININE; CYCLOPHOSPHAMIDE; ELECTROLYTE; ERYTHROPOIETIN; FUROSEMIDE; GLUCOSE; HYDROXYCHLOROQUINE; IMMUNOGLOBULIN; LONG ACTING DRUG; NIFEDIPINE; NITROGEN; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISOLONE; PREDNISONE; RANITIDINE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RETICULIN; SALAZOSULFAPYRIDINE; UREA;

AGED; ARTICLE; BLAST CELL; BLOOD SMEAR; BONE MARROW BIOPSY; CASE REPORT; DRUG WITHDRAWAL; HEMOPHAGOCYTIC SYNDROME; HISTIOCYTOSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MONOCYTE; MYELODYSPLASIA; PRIORITY JOURNAL; SIDE EFFECT;

AGED; BIOPSY; FILGRASTIM; GRANULOCYTE COLONY-STIMULATING FACTOR; HISTIOCYTOSIS; HUMANS; MALE; NEURAL TUBE DEFECTS; PHAGOCYTOSIS; TIME FACTORS; TREATMENT FAILURE;

EID: 34547686035     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.20854     Document Type: Article

References (17)

1. Fisman DN. Hemophagocytic syndromes and infection. Emerg Infect Dis 2000;6:601-608.
2. Arico M, Danasino C, Pende D, Moretta L. Pathogenesis of haemophagocytic lympho-histiocytosis. Br J Haematol 2001;114:761-769.
3. Karandikar NJ, Kroft SH, Submaranian Y, et al. Unusual immunophenotype of CD8+ T cells in familial hemophagocytic lymphohistiocytosis. Blood 2004;104:2007-2009.
4. Hubel K, Dale DC, Liles WC. Therapeutic use of cytokines to modulate phagocyte function for the treatment of infectious diseases: Current status of granulocyte colony-stimulating factor, granulocyte-macrophage colony stimulating factor, macrophage colony-stimulating factor, and interferon-γ. J Infect Dis 2002;185:1490-1501.
5. Janka G, Imashuku S, Elinder G, et al. Infection- and-malignancy- associated hemophagocytic syndromes. Hematol Oncol Clin North Am 1998;12:435-444.
6. Azuma E, Tabeta N, Shibata T, et al. G-CSF enhanced granulocyte production in a child with severe neutropenia in the setting of fatal virus-associated hemophagocytic syndrome. Am J Hematol 1990;35:266-268.
7. Al-Eid W, Al-Jefri A, Bahabri S. Hemophagocytosis complicating Kawaski disease. Pediatr Hematol Oncol 2000;17:323-329.
8. Shome DK, Al-Mukharraq H, Makdi N, et al. Clincopathological aspects of Chediak-Higashi syndrome in the accelerated phase. Saudi Med J 2002;23:464-466.
9. Ohsaka A, Saionji K, Kuwaki T, et al. Granulocyte colony-stimulating factor administration modulates the surface expression of effector cell molecules on human monocytes. Br J Haematol 1995;89:465-472.
10. Boneberg E, Hareng L, Gantner F, et al. Human monocytes express functional receptors for granulocyte colony-stimulating factor that mediate suppression of monokines and interferon-γ. Blood 2000;95:270-276.
11. Crawford J. Neutrophil growth factors. Curr Hematol Rep 2002;1:95-102.
12. Physicians Desk Reference, 59th ed. New Jersey: Thomson PDR; 2005. pp 590-592.
13. Lee KY, Suh BG, Kim JW, et al. Varying expression levels of colony stimulating factor receptors in disease states and different leukocytes. Exp Mol Med 2000;32:210-215.
14. Meyerson HJ, Farhi D, Rosental NS. Transient increase in blasts mimicking acute leukemia and progressing myelodysplasia in patients receiving growth factor. Am J Clin Pathol 1998;109:675-681.
15. Billiau D, Roskams T, Van Damme-Lombaerts R, et al. Macrophage activation syndrome: Characteristic findings on liver biopsy illustrating a key role of activated, IFN-γ-producing lymphocytes and IL-6- and TNF-α-producing macrophages. Blood 2005;105:1648-1651.
16. Quesnel B, Catteau B, Aznar Y, et al. Successful treatment of juvenile rheumatoid arthritis-associated haemophagocytic syndrome by cyclosporin A with a transient exacerbation by conventional-dose G-CSF. Br J Haematol 1997;97:508-510.
17. Wang S, Degar BA, Zieske A, et al. Hemophagocytosis exacerbated by G-CSF/GM-CSF treatment in a patient with myelodysplasia. Am J Hematol 2004;77:391-396.