Is there an association between hemostatic abnormalities and the outcome of acute lung injury?

Critical Care Medicine

Volumn 35, Issue 8, 2007, Pages 1980-1982

  Knoebl, Paul N ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Acute lung injury; Acute respiratory distress syndrome; Fibrinolysis; Hemostasis; Plasminogen activator inhibitor; Protein C; Sepsis

Indexed keywords

ACTIVATED PROTEIN C; D DIMER; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTHROMBIN;

ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; ARTIFICIAL VENTILATION; BLOOD CLOTTING; BLOOD SAMPLING; CORRELATION ANALYSIS; CRITICALLY ILL PATIENT; EDITORIAL; FIBRINOLYSIS; HEMOSTASIS; HUMAN; INFLAMMATION; LUNG INSUFFICIENCY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SEPSIS;

BIOLOGICAL MARKERS; BLOOD COAGULATION DISORDERS; FIBRINOLYSIS; HUMANS; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROGNOSIS; PROTEIN C; RESPIRATORY DISTRESS SYNDROME, ADULT; SEPSIS;

EID: 34547678170     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000277253.47121.6B     Document Type: Editorial

References (14)

1. Abraham E: Coagulation abnormalities in acute lung injury and sepsis. Am J Respir Cell Mol Biol 2000; 22:401-404
2. Idell S: Coagulation, fibrinolysis, and fibrin deposition in acute lung injury. Crit Care Med 2003; 31(Suppl):S213-S220
3. Schultz MJ, Haitsma JJ, Zhang H, et al: Pulmonary coagulopathy as a new target in therapeutic studies of acute lung injury or pneumonia - a review. Crit Care Med 2006; 34:871-877
4. Bastarache JA, Ware LB, Bernard GR: The role of the coagulation cascade in the continuum of sepsis and acute lung injury and acute respiratory distress syndrome. Semin Respir Crit Care Med 2006; 27:365-376
5. Belperio JA, Keane MP, Lynch JP, et al: The role of cytokines during the pathogenesis of ventilator-associated and ventilator-induced lung injury. Semin Respir Crit Care Med 2006; 27:350-364
6. Russell JA: Genetics of coagulation factors in acute lung injury. Crit Care Med 2003; 31(Suppl):S243-S247
7. Sapru A, Wiemels JL, Witte JS, et al: Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways. Intensive Care Med 2006; 32:1293-1303
8. Liaw PC, Esmon Ct, Kahnamoui K, et al: Patients with severe sepsis vary markedly in their ability to generate activated protein C. Blood 2004; 104:3958-3964
9. Macias WL, Nelson DR: Severe protein C deficiency predicts early death in severe sepsis. Crit Care Med 2004; 32(Suppl):S223-S228
10. Bernard G, Vincent J-L, Laterre P-F, et al: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344:699-709
11. Laterre PF, Wittebole X, Dhainaut JF: Anticoagulant therapy in acute lung injury. Crit Care Med 2003; 31(Suppl):S329-S336
12. Levitt JE, Matthay MA: Treatment of acute lung injury: Historical perspective and potential future therapies. Semin Respir Crit Care Med 2006; 27:426-438
13. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342:1301-1308
14. Ware LB, Matthay MA, Parsons PE, et al: Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in ALI/ARDS. Crit Care Med 2007; 35:1821-1828