Ossification of the posterior longitudinal ligament of the cervical spine: Histopathological findings around the calcification and ossification front

Journal of Neurosurgery: Spine

Volumn 7, Issue 2, 2007, Pages 174-183

  Sato, Ryuichiro ^a   Uchida, Kenzo ^a   Kobayashi, Shigeru ^a   Yayama, Takafumi ^a   Kokubo, Yasuo ^a   Nakajima, Hideaki ^a   Takamura, Takaharu ^a   Bangirana, Alexander ^b   Itoh, Hiroshi ^a   Baba, Hisatoshi ^a  

^a UNIVERSITY OF FUKUI   (Japan)

^b MAKERERE UNIVERSITY MEDICAL SCHOOL   (Uganda)

Author keywords

Calcification; Cervical spine; Histology; Immunohistochemistry; Ossification of the posterior longitudinal ligament

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; COLLAGEN TYPE 10; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

ADULT; AGED; APOPTOSIS; ARTICLE; BONE ATROPHY; CARTILAGE CELL; CERVICAL SPINE; ELASTIC FIBER; ENCHONDRAL OSSIFICATION; FEMALE; FIBROBLAST; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIGAMENT CALCINOSIS; MALE; METAPLASIA; NEOVASCULARIZATION (PATHOLOGY); NICK END LABELING; POSTERIOR LONGITUDINAL LIGAMENT; PROTEIN EXPRESSION;

ADULT; AGED; APOPTOSIS; BONE MORPHOGENETIC PROTEINS; CARTILAGE, ARTICULAR; CERVICAL VERTEBRAE; CHONDROCYTES; COLLAGEN TYPE I; COLLAGEN TYPE II; ELASTIC TISSUE; FIBROBLASTS; HUMANS; HYPERTROPHY; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; METAPLASIA; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; OSSIFICATION OF POSTERIOR LONGITUDINAL LIGAMENT; TISSUE DISTRIBUTION; TRANSFORMING GROWTH FACTOR BETA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 34547650851     PISSN: 15475654     EISSN: None     Source Type: Journal    
DOI: 10.3171/SPI-07/08/174     Document Type: Article

References (35)

1. Baba H, Furusawa N, Chen Q, Imura S, Tomita K: Anterior decompressive surgery for cervical ossified posterior longitudinal ligament causing myeloradiculopathy. Paraplegia 33:18-24, 1995
2. Baba H, Furusawa N, Fukuda M, Maezawa Y, Imura S, Kawahara N, et al: Potential role of streptozotocin in enhancing ossification of the posterior longitudinal ligament of the cervical spine in the hereditary spinal hyperostotic mouse (twy/twy). Eur J Histochem 41:191-202, 1997
3. Baba H, Maezawa Y, Imura S, Kawahara N, Nakahashi K, Tomita K: Quantitative analysis of the spinal cord motoneuron under chronic compression: an experimental observation in the mouse. J Neurol 243:109-116, 1996
4. Baba H, Uchida K, Sadato N, Yonekura Y, Kamoto Y, Maezawa Y, et al: Potential usefulness of 18F-2-fluoro-deoxy-D-glucose-positron emission tomography in cervical compressive myelopathy. Spine 24:1449-1454, 1999
5. Chiba K, Yamamoto I, Hirabayashi H, Iwasaki M, Goto H, Yonenobu K, et al: Multicenter study investigating the postoperative progression of ossification of the posterior longitudinal ligament in the cervical spine: a new computer-assisted measurement. J Neurosurg Spine 3:17-23, 2005
6. Epstein NE: Circumferential cervical surgery for ossification of the posterior longitudinal ligament: a multianalytic outcome study. Spine 29:1340-1345, 2004
7. Furukawa K: Current topics in pharmacological research on bone metabolism: molecular basis of ectopic bone formation induced by mechanical stress. J Pharmacol Sci 100:201-204, 2006
8. Furusawa N, Baba H, Imura S, Fukuda M: Characteristics and mechanism of the ossification of posterior longitudinal ligament in the tip-toe walking Yoshimura (twy) mouse. Eur J Histochem 40:199-210, 1996
9. Furushima K, Shimo-Onoda K, Maeda S, Nobukuni T, Ikari K, Koga H, et al: Large-scale screening for candidate genes of ossification of the posterior longitudinal ligament of the spine. J Bone Miner Res 17:128-137, 2002
10. Havelka S, Vesela M, Pavelkova A, Ruzickova S, Koga H, Maeda S, et al: Are DISH and OPLL genetically related? Ann Rheum Dis 60:902-903, 2001
11. Hirakawa H, Kusumi T, Nitobe T, Ueyama K, Tanaka M, Kudo H, et al: An immunohistochemical evaluation of extracellular matrix components in the spinal posterior longitudinal ligament and intervertebral disc of tiptoe walking mouse. J Orthop Sci 9:591-597, 2004
12. Horikoshi T, Maeda K, Kawaguchi Y, Chiba K, Mori K, Koshizawa Y, et al: A large-scale genetic association study of ossification of the posterior longitudinal ligament of the spine. Hum Genet 119:611-616, 2006
13. Inoue I, Ikeda R, Tsukahara S: Current topics in pharmacological research on bone metabolism: promyelotic leukemia zinc finger (PLZF) and tumor necrosis factor-alpha-stimulated gene 6 (TSG-6) identified by gene expression analysis play roles in the pathogenesis of ossification of the posterior longitudinal ligament. J Pharmacol Sci 100:205-210, 2006
14. Ishida Y, Kawai S: Effects of bone-seeking hormones on DNA synthesis, cyclic AMP level, and alkaline phosphatase activity in cultured cells from human posterior longitudinal ligament of the spine. J Bone Miner Res 8:1291-1300, 1993
15. Iwasaki K, Furukawa KI, Tanno M, Kusumi T, Ueyama K, Tanaka M, et al: Uni-axial cyclic stretch induces Cbfa1 expression in spinal ligament cells derived from patients with ossification of the posterior longitudinal ligament. Calcif Tissue Int 74:448-457, 2004
16. Kawaguchi H, Kurokawa T, Hoshino Y, Kawahara H, Ogata E, Matsumoto T: Immunohistochemical demonstration of bone morphogenetic protein-2 and transforming growth factor-beta in the ossification of the posterior longitudinal ligament of the cervical spine. Spine 17 (3 Suppl):S33-S36, 1992
17. Koga H, Sakou T, Taketomi E, Hayashi K, Numasawa T, Harata S, et al: Genetic mapping of ossification of the posterior longitudinal ligament of the spine. Am J Hum Genet 62:1460-1467, 1998
18. Kokubo Y, Kobayashi S, Uchida K, Noriki S, Imamura S, Furusawa N, et al: Herniated and spondylotic intervertebral discs of the human cervical spine: histological and immunohistological observations. Acta Histochem Cytochem 37:109-117, 2004
19. Maeda S, Ishidou Y, Koga H, Taketomi E, Ikari K, Komiya S, et al: Functional impact of human collagen alpha2(XI) gene polymorphism in pathogenesis of ossification of the posterior longitudinal ligament of the spine. J Bone Miner Res 16:948-957, 2001
20. McAfee PC, Regan JJ, Bohlman HH: Cervical cord compression from ossification of the posterior longitudinal ligament in non-orientals. J Bone Joint Surg Br 69:569-575, 1987
21. Okawa A, Nakamura I, Goto S, Moriya H, Nakamura Y, Ikegawa S: Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet 19:271-273, 1998
22. Ramos-Remus C, Russell AS, Gomez-Vargas A, Hernandez-Chavez A, Maksymowych WP, Gamez-Nava JI, et al: Ossification of the posterior longitudinal ligament in three geographically and genetically different populations of ankylosing spondylitis and other spondyloarthropathies. Ann Rheum Dis 57:429-433, 1998
23. Sakou T, Taketomi E, Matsunaga S, Yamaguchi M, Sonoda S, Yashiki S: Genetic study of ossification of the posterior longitudinal ligament in the cervical spine with human leukocyte antigen haplotype. Spine 16:1249-1252, 1991
24. Seichi A, Hoshino Y, Ohnishi I, Kurokawa T: The role of calcium metabolism abnormalities in the development of ossification of the posterior longitudinal ligament of the cervical spine. Spine 17 (3 Suppl):S30-S32, 1992
25. Tanno M, Furukawa KI, Ueyama K, Harata S, Motomura S: Uniaxial cyclic stretch induces osteogenic differentiation and synthesis of bone morphogenetic proteins of spinal ligament cells derived from patients with ossification of the posterior longitudinal ligaments. Bone 33:475-484, 2003
26. Tsukahara S, Miyazawa N, Akagawa H, Forejtova S, Pavelka K, Tanaka T, et al: COL6A1, the candidate gene for ossification of the posterior longitudinal ligament, is associated with diffuse idiopathic skeletal hyperostosis in Japanese. Spine 30:2321-2324, 2005
27. Tsukamoto N, Maeda T, Miura H, Jingushi S, Hosokawa A, Harimaya K, et al: Repetitive tensile stress to the rat caudal vertebrae inducing cartilage formation in the spinal ligaments: a possible role of mechanical stress in the development of ossification of the spinal ligaments. J Neurosurg Spine 5:234-242, 2006
28. Uchida K, Baba H, Maezawa Y, Furukawa S, Furusawa N, Imura S: Histological investigation of spinal cord lesions in the spinal hyperostotic mouse (twy/twy): morphological changes in anterior horn cells and immunoreactivity to neurotrophic factors. J Neurol 245:781-793, 1998
29. Uchida K, Kobayashi S, Yayama T, Kokubo Y, Nakajima H, Sadato N, et al: Metabolic neuroimaging of the cervical spinal cord in patients with compressive myelopathy: a high-resolution positron emission tomography study. J Neurosurg Spine 1:72-79, 2004
30. Ueno T, Kagawa T, Kanou M, Fujii T, Fukunaga J, Mizukawa N, et al: Vascular endothelial growth factor (VEGF) and bone morphogenetic protein-4 (BMP-4) in endochondral ossification from grafted periosteum. Acta Histochem Cytochem 36:61-66, 2003
31. Yamamoto Y, Furukawa K, Ueyama K, Nakanishi T, Takigawa M, Harata S: Possible roles of CTGF/Hcs24 in the initiation and development of ossification of the posterior longitudinal ligament. Spine 27:1852-1857, 2002
32. Yayama T, Baba H, Furusawa N, Kobayashi S, Uchida K, Kokubo Y, et al: Pathogenesis of the calcium crystal deposition in the ligamentum flavum correlates with lumbar spinal canal stenosis. Clin Exp Rheumatol 23:637-643, 2005
33. Yonemori K, Imamura T, Ishidou Y, Okano T, Matsunaga S, Yoshida H, et al: Bone morphogenetic protein receptors and activin receptors are highly expressed in ossified ligament tissues of patients with ossification of the posterior longitudinal ligament. Am J Pathol 150:1335-1347, 1997
34. Yoshikawa H: Possible roles of bone morphogenetic proteins and transforming growth factor-βs in the pathogenesis of OPLL and OLF, in Yonenobu K, Nakamura K, Toyama Y (eds): OPLL: Ossification of the Posterior Longitudinal Ligament, ed 2. Berlin: Springer-Verlag, 2006, pp 59-63
35. Yoshizawa T, Takizawa F, Iizawa F, Ishibashi O, Kawashima H, Matsuda A, et al: Homeobox protein MSX2 acts as a molecular defence mechanism for preventing ossification in ligament fibroblasts. Mol Cell Biol 24:3460-3472, 2004