Do sporadic Peutz-Jeghers polyps exist? Experience of a large teaching hospital

American Journal of Surgical Pathology

Volumn 31, Issue 8, 2007, Pages 1209-1214

  Burkart, Ashlie L ^a   Sheridan, Todd ^a   Lewin, Marc ^a   Fenton, Hubert ^a   Ali, Nilofar J ^b   Montgomery, Elizabeth ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

^b Dianon Systems   (United States)

Author keywords

Hamartomatous polyps; LKB1; Peutz Jeghers polyp; Small intestine; Sporadic polyps; STK11

Indexed keywords

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER RISK; CLINICAL ARTICLE; COLON POLYP; CONTROLLED STUDY; DATA ANALYSIS; DATA BASE; DYSPLASIA; FAMILY HISTORY; FEMALE; GASTROINTESTINAL MALFORMATION; GLOMUS TYMPANICUM; GLOMUS TYMPANICUM TUMOR; HISTOLOGY; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; INCIDENCE; MALE; MEDICAL INFORMATION SYSTEM; OVARY CYST; PANCREAS CANCER; PATHOLOGIST; PATHOLOGY; PEUTZ JEGHERS SYNDROME; POLYP; SMALL INTESTINE; TEACHING HOSPITAL; TISSUE INJURY; VILLOUS ADENOMA; WORLD HEALTH ORGANIZATION;

ADULT; AGED; DATABASES, FACTUAL; FEMALE; HOSPITALS, TEACHING; HUMANS; INTESTINAL POLYPS; INTESTINES; MALE; MIDDLE AGED; PEUTZ-JEGHERS SYNDROME;

EID: 34547642661     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/PAS.0b013e3180339944     Document Type: Article

References (26)

1. Aaltonen L, Jarviner H, Gruber S. Peutz-Jehgers syndrome. In: Hamilton S, Aaltonen L, eds. Tumours of the Digestive System. Lyon, France: IACR; 2000:74-76.
2. Abraham SC, Singh VK, Yardley JH, et al. Hyperplastic polyps of the stomach: associations with histologic patterns of gastritis and gastric atrophy. Am J Surg Pathol. 2001;25:500-507.
3. Amos CI, Keitheri-Cheteri MB, Sabripour M, et al. Genotype-phenotype correlations in Peutz-Jeghers syndrome. J Med Genet. 2004;41:327-333.
4. Boardman LA, Thibodeau SN, Schaid DJ, et al. Increased risk for cancer in patients with the Peutz-Jeghers syndrome. Ann Intern Med. 1998;128:896-899.
5. Boardman LA, Couch FJ, Burgart LJ, et al. Genetic heterogeneity in Peutz-Jeghers syndrome. Hum Mutat. 2000;16:23-30.
6. Entius MM, Keller JJ, Westerman AM, et al. Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome. J Clin Pathol. 2001;54:126-131.
7. Flageole H, Raptis S, Trudel JL, et al. Progression toward malignancy of hamartomas in a patient with Peutz-Jeghers syndrome: case report and literature review. Can J Surg. 1994;37:231-236.
8. Giardiello FM, Welsh SB, Hamilton SR, et al. Increased risk of cancer in the Peutz-Jeghers syndrome. N Engl J Med. 1987;316:1511-1514.
9. Giardiello FM, Trimbath JD. Peutz-Jeghers syndrome and management recommendations. Clin Gastroenterol Hepatol. 2006;4:408-415.
10. Hearle N, Schumacher V, Menko FH, et al. Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clin Cancer Res. 2006;12:3209-3215.
11. Hearle N, Schumacher V, Menko FH, et al. STK11 status and intussusception risk in Peutz-Jeghers syndrome. J Med Genet. 2006;43:e41.
12. Hearle NC, Rudd MF, Lim W, et al. Exonic STK11 deletions are not a rare cause of Peutz-Jeghers syndrome. J Med Genet. 2006;43:e15.
13. Hemminki A, Tomlinson I, Markie D, et al. Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis. Nat Genet. 1997;15:87-90.
14. Ichiyoshi Y, Yao T, Nagasaki S, et al. Solitary Peutz-Jeghers type polyp of the duodenum containing a focus of adenocarcinoma. Ital J Gastroenterol. 1996;28:95-97.
15. Jeghers H, McKusick VA, Katz KH. Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits; a syndrome of diagnostic significance. N Engl J Med. 1949;241:1031-1036.
16. Jenne DE, Reimann H, Nezu J, et al. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet. 1998;18:38-43.
17. Kitaoka F, Shiogama T, Mizutani A, et al. A solitary Peutz-Jeghers-type hamartomatous polyp in the duodenum. A case report including results of mutation analysis. Digestion. 2004;69:79-82.
18. Lim W, Hearle N, Shah B, et al. Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome. Br J Cancer. 2003;89:308-313.
19. Miller LJ, Bartholomew LG, Dozois RR, et al. Adenocarcinoma of the rectum arising in a hamartomatous polyp in a patient with Peutz-Jeghers syndrome. Dig Dis Sci. 1983;28:1047-1051.
20. Nakayama H, Fujii M, Kimura A, et al. A solitary Peutz-Jeghers-type hamartomatous polyp of the rectum: report of a case and review of the literature. Jpn J Clin Oncol. 1996;26:273-276.
21. Nebril A, Filguera T, Calvo P, et al. Solitary hamartomatous duodenal polyp, a different entity: report of a case and review of the literature. Surg Today. 1993;23:1074-1077.
22. Oncel M, Remzi FH, Church JM, et al. Course and follow-up of solitary Peutz-Jeghers polyps: a case series. Int J Colorectal Dis. 2003;18:33-35.
23. Perzin KH, Bridge MF. Adenomatous and carcinomatous changes in hamartomatous polyps of the small intestine (Peutz-Jeghers syndrome): report of a case and review of the literature. Cancer. 1982;49:971-983.
24. Peutz J. Very remarkable case of familial polyposis of mucous membrane of intestinal tract and nasopharynx accompanied by peculiar pigmentations of skin and mucous membrane. Nederl naandschr v geneesk. 1921;10:134-146.
25. Ylikorkala A, Avizienyte E, Tomlinson IP, et al. Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer. Hum Mol Genet. 1999;8:45-51.
26. Young RH, Welch WR, Dickersin GR, et al. Ovarian sex cord tumor with annular tubules: review of 74 cases including 27 with Peutz-Jeghers syndrome and four with adenoma malignum of the cervix. Cancer. 1982;50:1384-1402.