Inhibitory effect of ginsenoside Rb1 on calcineurin signal pathway in cardiomyocyte hypertrophy induced by prostaglandin F 2α

Acta Pharmacologica Sinica

Volumn 28, Issue 8, 2007, Pages 1149-1154

  Jiang, Qing Song ^a   Huang, Xie Nan ^b   Yang, Gui Zhong ^b   Jiang, Xiao Yan ^c   Zhou, Qi Xin ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b ZUNYI MEDICAL UNIVERSITY   (China)

^c Chengdu Vocational College of Agricultural Science and Technology   (China)

Author keywords

Calcineurin; Cardiac hypertrophy; Prostaglandin F2 ; Rb1

Indexed keywords

ARGININE; ATRIAL NATRIURETIC FACTOR; CALCINEURIN; CALCIUM; GINSENOSIDE RB 1; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; PROSTAGLANDIN F2 ALPHA; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR NFAT;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL CULTURE; CELL SIZE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FLUORESCENCE; HEART HYPERTROPHY; HEART MUSCLE CELL; NONHUMAN; PROTEIN CONTENT; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; CALCINEURIN; CALCIUM; CARDIOMEGALY; CELLS, CULTURED; DINOPROST; GATA4 TRANSCRIPTION FACTOR; GINSENOSIDES; MYOCYTES, CARDIAC; NFATC TRANSCRIPTION FACTORS; RATS; SIGNAL TRANSDUCTION;

EID: 34547634868     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2007.00601.x     Document Type: Article

References (30)

1. Hunter JJ, Chien KR. Signaling pathways for cardiac hypertrophy and failure. N Engl Med 1999 341 : 1276 83.
2. Esposito G, Rapacciuolo A, Naga Prasad SV, Takaoka H, Thomas SA, Koch WJ, et al. Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevents cardiac dysfunction despite increased wall stress. Circulation 2002 105 : 85 92.
3. Jacobs TF, Ramsey LA. Angiotensin receptor blockers. Applications beyond hypertension. Adv Nurse Pract 2005 13 : 27 30.
4. Zhang R, Crump J, Reisin E. Regression of left ventricular hypertrophy is a key goal of hypertension management. Curr Hypertens Rep 2003 5 : 301 8.
5. Messerli FH. Evolution of calcium antagonists: past, present, and future. Clin Cardiol 2003 26 (Suppl 2 II12 6.
6. Kempf T, Wollert KC. Nitric oxide and the enigma of cardiac hypertrophy. Bioassays 2004 26 : 608 15.
7. Zhang JL, Xu WA, Yang YK, Zhang EY, Wang ZY, Zhang YZ. A primarily study on the relationship between the effect of Panax Notoginsen Rb1 Rg1 on the aging process. Acad J Kunming Med 2000 21 : 63 5. Chinese.
8. Jiang S, Jiang ZL. Protective effect of ginsenoside Rb1 on ischemic brain injury in rat. J Apoplexy Nervous Diseases 2003 20 : 415 7.
9. Guan L, Li W, Liu Z. Effect of ginsenoside Rb1 on cardiomyocyte apoptosis after ischemia and reperfusion in rats. J Huazhong Univ Sci Technol Med Sci 2002 22 : 212 5. Chinese.
10. Scott GI, Colligan PB, Ren BH, Ren J. Ginsenosides Rb1 and Re decrease cardiac contraction in adult rat ventricular myocytes: role of nitric oxide. Br J Pharmacol 2001 134 : 1159 65.
11. Jiang XY, Zhang JT, Shi CZ. Mechanism of action of ginsenoside Rb1 in decreasing intracellular Ca2+. Yao Xue Xue Bao 1996 31 : 321 6. Chinese.
12. Liu M, Zhang JT. Effects of ginsenoside Rb1 and Rg1 on synaptosomal free calcium level, ATPase and calmodulin in rat hippocampus. Chin Med J 1995 108 : 544 7.
13. Zhang WJ, Zhong GG, Jiang Y, Wang XM, Wang ZF. Single channel analysis on calcium channel blocked action of panaxadiol and panaxatriol saponins on cultured rat ventricular myocytes. Acta Pharmacol Sin 1994 15 : 173 6. Chinese.
14. Lai J, Jin H, Yang R, Winer J, Li W, Yen R, et al. Prostaglandin F2 alpha induces cardiac myocyte hypertrophy in vitro and cardiac growth in vivo. Am J Physiol 1996 271 : H2197 208.
15. Sugden PH. Signaling pathways in cardiac myocyte hypertrophy. Ann Med 2001 33 : 611 22.
16. Zhang W. Old and new tools to dissect calcineurin's role in pressure-overload cardiac hypertrophy. Cardiovasc Res 2002 53 : 294 303.
17. De Windt LJ, Lim HW, Haq S, Force T, Molkentin JD. Calcineurin promotes protein kinase C and c-jun NH2-terminal kinase activation in the heart, cross-talk between cardiac hypertrophic signaling pathways. J Biol Chem 2000 275 : 13571 9.
18. Hogan PG, Chen L, Nardone J, Rao H. Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev 2003 17 : 2205 32.
19. Vega RB, Bassel-Duby R, Olson EN. Control of cardiac growth and function by calcineurin signaling. J Biol Chem 2003 278 : 36981 4.
20. Xu SY, editor. Methodologies of pharmacological experiment. Beijing : The People's Medical Publishing House 2002.
21. Lei KJ, Huang XN, Wu Q, Xie XL, Yu LM, Lu YF. The effects of breviscapine on platelet aggregation and intra-platelet free calcium. Acta Acad Med Zunyi 2004 27 : 11 3. Chinese.
22. Taigen T, De Windt LJ, Molkentin JD. Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy. Proc Natl Acad Sci USA 2000 97 : 1196 201.
23. Abassi Z, Brodsky S, Gealekman O, Rubinstein I, Hoffman A, Winaver J. Intrarenal expression and distribution of cyclooxygenase isoforms in rats with experimental heart failure. Am J Physiol Renal Physiol 2001 280 : F43 53.
24. Ng DC, Long CS, Bogoyevitch MA. A role for the extracellular signal regulated kinase and p38 mitogen-activated protein ki-nases in interleukin-1 beta-stimulated delayed signal transducer and activator of transcription 3 activation, atrial natriuretic factor expression, and cardiac myocyte morphology. J Biol Chem 2001 276 : 29490 8.
25. Nakagami H, Takemoto M, Liao JK. NADPH oxidase-derived superoxide anion mediates angiotensin II-induced cardiac hypertrophy. J Mol Cell Cardiol 2003 35 : 851 9.
26. Fujino H, Srinivasan D, Pierce KL, Regan JW. Differential regulation of prostaglandin F2α receptor isoforms by protein kinase C. Mol Pharmacol 2000 57 : 353 8.
27. Chi en KR, Grace AA, Hunter JJ. Molecular and cellular biology of cardiac hypertrophy and failure. In : Chien KR, editor. Molecular basis of cardiovascular disease. Beijing : People's Medical Publishing House 2001. p 211 50.
28. Molkentin JD. Calcineurin and beyond: cardiac hypertrophic signaling. Circ Res 2000 87 : 731 8.
29. Jiang QS, Huang XN, Yang GZ, Dai ZK, Zhou QX, Shi JS, et al. Signal transduction pathway of cardiac hypertrophy induced by prostaglandin F2α may be mediated by calcineurin in rats. Acta Physiol Sin 2005 57 : 742 8.
30. Fiedler B, Wollert KC. Interference of antihypertrophic molecules and signaling pathways with the Ca2+-calcineurin-NFAT cascade in cardiac myocytes. Cardiovasc Res 2004 63 : 450 7.