Modified penicillin acylase signal peptide allows the periplasmic production of soluble human interferon-γ but not of soluble human interleukin-2 by the Tat pathway in Escherichia coli

Biotechnology Letters

Volumn 29, Issue 9, 2007, Pages 1369-1374

  Medina Rivero, E ^a   Balderas Hernandez V E ^a   Ordonez Acevedo L G ^a   Paz Maldonado, L M T ^a   Barba De La Rosa, A P ^a   De Leon Rodriguez A ^a  

^a INSTITUTO POTOSINO DE INVESTIGACIÓN CIENTÍFICA Y TECNOLÓGICA   (Mexico)

Author keywords

Periplasm; Signal peptide; Tat pathway; Therapeutic protein

Indexed keywords

ENZYME ACTIVITY; ESCHERICHIA COLI; GAMMA RAYS; PEPTIDES; POLYPEPTIDES; SOLUBILITY;

PERIPLASM; SIGNAL PEPTIDE; TAT PATHWAY; THERAPEUTIC PROTEIN; TRANSLOCATION PATHWAY;

INTERFERONS;

GAMMA INTERFERON; INTERLEUKIN 2; RECOMBINANT PROTEIN;

ARTICLE; CHEMISTRY; CYTOPLASM; ESCHERICHIA COLI; GENETICS; HUMAN; METABOLISM; METHODOLOGY; PHYSIOLOGY; PROTEIN ENGINEERING; SOLUBILITY;

ESCHERICHIA COLI; HUMANS; INTERFERON TYPE II; INTERLEUKIN-2; PERIPLASM; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; SOLUBILITY;

ESCHERICHIA COLI;

EID: 34547627639     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-007-9395-5     Document Type: Article

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