An assembly concept for the consecutive introduction of unsymmetrical disulfide bonds: Synthesis of a releasable multidrug conjugate of folic acid

Journal of Organic Chemistry

Volumn 72, Issue 16, 2007, Pages 5968-5972

  Vlahov, Iontcho R ^a   Santhapuram, Hari Krishna R ^a   Wang, Yu ^a   Kleindl, Paul J ^a   You, Fei ^a   Howard, Stephen J ^a   Westrick, Elaine ^a   Reddy, Joseph A ^a   Leamon, Christopher P ^a  

^a Endocyte Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; CHEMICAL BONDS; LIGANDS; ORGANIC ACIDS; SYNTHESIS (CHEMICAL);

CHEMICAL EQUATION; LINKER SYSTEM; MOLECULAR FRAMEWORK; MOLECULE POSSESSING;

DRUG PRODUCTS;

FLUORENE DERIVATIVE; FOLATE RECEPTOR; FOLIC ACID DERIVATIVE; THIOL DERIVATIVE;

ARTICLE; COVALENT BOND; DISULFIDE BOND; DRUG CONJUGATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; LIGAND BINDING; REACTION ANALYSIS;

CARRIER PROTEINS; CHEMISTRY, ORGANIC; CHEMISTRY, PHARMACEUTICAL; DISULFIDES; DRUG DELIVERY SYSTEMS; DRUG DESIGN; FOLIC ACID; LIGANDS; MODELS, CHEMICAL; PEPTIDES; SULFHYDRYL COMPOUNDS;

EID: 34547621826     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo070411z     Document Type: Article

References (10)

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