Fosamprenavir plus ritonavir increases plasma ketoconazole and ritonavir exposure, while amprenavir exposure remains unchanged

Antimicrobial Agents and Chemotherapy

Volumn 51, Issue 8, 2007, Pages 2982-2984

  Wire, Mary B ^a   Ballow, Charles H ^b   Borland, Julie ^a   Shelton, Mark J ^a   Lou, Yu ^a   Yuen, Geoffrey ^a   Lin, Jiang ^a   Lewis, Eric W ^a  

^a GLAXOSMITHKLINE   (United States)

^b Buffalo Clinical Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPRENAVIR; AMPRENAVIR PHOSPHATE; KETOCONAZOLE; LOPINAVIR; LOPINAVIR PLUS RITONAVIR; RITONAVIR;

ADULT; AREA UNDER THE CURVE; ARTICLE; DIARRHEA; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HEADACHE; HUMAN; HUMAN EXPERIMENT; LIMB PAIN; MALE; NAUSEA; NORMAL HUMAN; PRIORITY JOURNAL; RASH; STEADY STATE;

ADOLESCENT; ADULT; ANTIFUNGAL AGENTS; AREA UNDER CURVE; CARBAMATES; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; FEMALE; HIV PROTEASE INHIBITORS; HUMANS; KETOCONAZOLE; MALE; MIDDLE AGED; PHOSPHORIC ACID ESTERS; RITONAVIR; SULFONAMIDES; TREATMENT OUTCOME;

EID: 34547617204     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00008-07     Document Type: Article

References (2)

1. Khaliq, Y. K. Gallicano, S. Venance, S. Kravcik, and D. W. Cameron. 2000. Effect of ketoconazole on ritonavir and saquinavir concentrations in plasma and cerebrospinal fluid from patients infected with human immunodeficiency virus. Clin. Pharmacol. Ther. 68:637-646.
2. Polk, R. E., M. A. Crouch, A. Pastor, W. Gouldin, D. S. Israel, B. M. Sadler, W. T. Symonds, Y. Lou, and G. E. Chittick. 1999. Pharmacokinetic interaction between ketoconazole and amprenavir after single doses in healthy men. Pharmacotherapy 19:1378-1384.