Tolls: You pay them on the way in and on the way out!

Journal of Infectious Diseases

Volumn 196, Issue 4, 2007, Pages 497-498

  Finberg, Robert W ^a,b   Kurt Jones, Evelyn A ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b LRB 228 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 10; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR;

ADAPTIVE IMMUNITY; ALLELE; B LYMPHOCYTE ACTIVATION; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; EDITORIAL; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HUMAN; INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; SEPTIC SHOCK; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; VIRUS REACTIVATION;

ANIMALS; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; COMMUNICABLE DISEASES; CYTOKINES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNITY, ACTIVE; POLYMORPHISM, GENETIC; RECURRENCE; T-LYMPHOCYTES; TOLL-LIKE RECEPTORS; VIRUS ACTIVATION;

EID: 34547615983     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/519694     Document Type: Editorial

References (16)

1. Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol 2003; 21:335-76.
2. Bochud P-Y, Magaret AS, Koelle DM, Aderem A, Wald A. Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus type 2 infection. J Infect Dis 2007; 196:505-9 (in this issue).
3. Pasare C, Medzhitov R. Toll-dependent control mechanisms of CD4 T cell activation. Immunity 2004; 21:733-41.
4. Kaisho T, Takeuchi O, Kawai T, Hoshino K, Akira S. Endotoxin-induced maturation of MyD88-deficient dendritic cells. J Immunol 2001; 166:5688-94.
5. Blander JM, Medzhitov R. On regulation of phagosome maturation and antigen presentation. Nat Immunol 2006; 7:1029-35.
6. Bochud PY, Hawn TR, Aderem A. Cutting edge: a toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling. J Immunol 2003; 170:3451-4.
7. Krutzik SR, Ochoa MT, Sieling PA, et al. Activation and regulation of Toll-like receptors 2 and 1 in human leprosy. Nat Med 2003; 9:525-32.
8. Pasare C, Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 2003; 299:1033-6.
9. Caramalho I, Lopes-Carvalho T, Ostler D, Zelenay S, Haury M, Demengeot J. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med 2003; 197:403-11.
10. Honda K, Taniguchi T. IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol 2006; 6:644-58.
11. Meylan E, Tschopp J. Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses. Mol Cell 2006; 22:561-9.
12. Schnare M, Barton GM, Holt AC, Takeda K, Akira S, Medzhitov R. Toll-like receptors control activation of adaptive immune responses. Nat Immunol 2001; 2:947-50.
13. Zhou S, Kurt-Jones EA, Mandell L, et al. MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infection. Eur J Immunol 2005; 35:822-30.
14. Zhou S, Kurt-Jones EA, Fitzgerald KA, et al. Role of MyD88 in route-dependent suspectibility to vesicular stomatitis virus infection. J Immunol 2007; 178:5173-81.
15. Kurt-Jones EA, Chan M, Zhou S, et al. Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Proc Natl Acad Sci USA 2004; 101:1315-20.
16. Kurt-Jones EA, Belko J, Yu C, et al. The role of toll-like receptors in herpes simplex infection in neonates. J Infect Dis 2005; 191:746-8.