Expression of L* protein of Theiler's murine encephalomyelitis virus in the chronic phase of infection

Journal of General Virology

Volumn 88, Issue 8, 2007, Pages 2268-2274

  Asakura, Kunihiko ^a   Murayama, Harunobu ^b   Himeda, Toshiki ^a,c   Ohara, Yoshiro ^a  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

^b SENDAI CITY HOSPITAL   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; VIRUS PROTEIN; L(ASTERISK) PROTEIN, THEILER'S ENCEPHALOMYELITIS VIRUS; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; VIRUS RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CHRONIC DISEASE; CONTROLLED STUDY; DEMYELINATION; GENE IDENTIFICATION; GENE INSERTION; HISTOPATHOLOGY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MOUSE; MURINE ENCEPHALOMYELITIS VIRUS; NERVE CELL; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN SYNTHESIS; SPINAL CORD; START CODON; VIROGENESIS; VIRUS GENOME; VIRUS INFECTION; VIRUS MUTANT; ANIMAL; CELL LINE; CHEMISTRY; DEMYELINATING DISEASE; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MUTATION; PATHOLOGY; POLIOMYELITIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIROLOGY;

MUS; THEILER'S ENCEPHALOMYELITIS VIRUS;

ANIMALS; CELL LINE; CHRONIC DISEASE; DEMYELINATING DISEASES; MEMBRANE PROTEINS; MICE; MUTATION; POLIOMYELITIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; SPINAL CORD; THEILOVIRUS; VIRAL PROTEINS;

EID: 34547609872     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.82381-0     Document Type: Article

References (23)

1. Asakura, K., Murayama, H., Himeda, T. & Ohara, Y. (2002). Epitope-tagged L* protein of Theiler's murine encephalomyelitis virus is expressed in the central nervous system in the acute phase of infection. J Virol 76, 13049-13054.
2. Chen, H.-H., Kong, W.-P. & Roos, R. P. (1995a). The leader peptide of Theiler's murine encephalomyelitis virus is a zinc-binding protein. J Virol 69, 8076-8078.
3. Chen, H.-H., Kong, W.-P., Zhang, L, Ward, P. L. & Roos, R. P. (1995b). A picomaviral protein synthesized out of frame with the polyprotein plays a key role in a virus-induced immune-mediated demyelinating disease. Nat Med 1, 927-931.
4. Clatch, R. J., Miller, S. D., Metzner, R., Dal Canto, M. C. & Lipton, H. L. (1990). Monocytes/macrophages isolated from the mouse central nervous system contain infectious Theiler's in murine encephalomyelitis virus (TMEV). Virology 176, 244-254.
5. Delhaye, S., van Pesch, V. & Michiels, T. (2004). The leader protein of Theiler's virus interferes with nucleocytoplasmic trafficking of cellular proteins. J Virol 78, 4357-4362.
6. Ghadge, G. D., Ma, L., Sato, S., Kim, J. & Roos, R. P. (1998). A protein critical for a Theiler's virus-induced immune system-mediated demyelinating disease has a cell type-specific anti-apoptotic effect and a key role in virus persistence. J Virol 72, 8605-8612.
7. Himeda, T., Ohara, Y., Asakura, K., Kontani, Y., Murakami, M, Suzuki, H. & Sawada, M. (2005). A lentiviral expression system demonstrates that L* protein of Theiler's murine encephalomyelitis virus (TMEV) is essential for virus growth in a murine macrophage- like cell line. Virus Res 108, 23-28.
8. Kong, W.-P. & Roos, R. P. (1991). Alternative translation initiation site in the DA strain of Theiler's murine encephalomyelitis virus. J Virol 65, 3395-3399.
9. Kong, W. P., Ghadge, G. D. & Roos, R. P. (1994). Involvement of cardiovirus leader in host cell-restricted virus expression. Proc Natl Acad Sci U S A 91, 1796-1800.
10. Lipton, H. L., Twaddle, G. & Jelachich, M. L. (1995). The predominant virus antigen burden is present in macrophages in Theiler's murine encephalomyelitis virus-induced demyelinating disease. J Virol 69, 2525-2533.
11. Michiels, T., Jarousse, N. & Brachic, M. (1995). Analysis of the leader and capsid coding regions of persistent and neurovirulent strains of Theiler's virus. Virology 214, 550-558.
12. Obuchi, M. & Ohara, Y. (1998). Theiler's murine encephalomyelitis virus and mechanisms of its persistence. Neuropathology 18, 13-18.
13. Obuchi, M., Yamamoto, J., Odagiri, T., Uddin, M. N., Iizuka, H. & Ohara, Y. (2000). L* protein of Theiler's murine encephalomyelitis virus is required for virus growth in a murine macrophage-like cell line. J Virol 74, 4898-4901.
14. Obuchi, M., Odagiri, T., Asakura, K. & Ohara, Y. (2001). Association of L* protein of Theiler's murine encephalomyelitis virus with microtubules in infected cells. Virology 289, 95-102.
15. Ohara, Y., Stein, S, Fu, J., Stillman, L., Klaman, L. & Roos, R. P. (1988). Molecular cloning and sequence determination of DA strain of Theiler's murine encephalomyelitis viruses. Virology 164, 245-255.
16. Oleszak E. L., Chang, J. R., Friedman, H., Katsetos., C. D. & Platsoucas, C. D. (2004). Theiler's virus infection: a model for multiple sclerosis. Clin Microbiol Rev 17, 174-207.
17. Roos, R. P. (2002). Pathogenesis of Theiler's murine encephalomyelitis virus-induced disease. In Molecular Biology of Picornaviruses, pp. 427-435. Edited by B. L. Semler & E. Wimmer. Washington, DC: American Society for Microbiology.
18. Roos, R. P., Stein, S., Ohara, Y., Fu, J. & Semler, B. L. (1989). Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virus. J Virol 63, 5492-5496.
19. Rossi, C. P,, Delcroix, M., Huitinga, I., McAllister, A, van Rooijen, N., Claassen, E. & Brahic, M. (1997). Role of macrophages during Theiler's virus infection. J Virol 71, 3336-3340.
20. Takata, H., Obuchi, M., Yamamoto, J., Odagiri, T., Roos, R. P., Iizuka, H. & Ohara, Y. (1998). L* protein of the DA strain of Theiler's murine encephalomyelitis virus is important for virus growth in a murine macrophage-like cell line. J Virol 72, 4950-4955.
21. van Eyll, O. & Michiels, T. (2000). Influence of the Theiler's virus L* protein on macrophage infection, viral persistence, and neurovirulence. J Virol 74, 9071-9077.
22. van Eyll, O. & Michiels, T. (2002). Non-AUG-initiated internal translation of the L* protein of Theiler's virus and importance of this protein for viral persistence. J Virol 76, 10665-10673.
23. van Pesch, V., van Eyll, O., & Michiels, T. (2001). The leader protein of Theiler's virus inhibits immediate-early alpha/beta interferon production. J Virol 75, 7811-7817.