Astrocytic pathology in the immune-mediated motor neuron injury

Amyotrophic Lateral Sclerosis

Volumn 8, Issue 4, 2007, Pages 230-234

  Guo, Yansu ^a,b   Liu, Yaling ^a,b   Xu, Lei ^a,b   Wu, Shuyu ^a,b   Yang, Cheng ^a,b   Wu, Dongxia ^a,b   Wu, Hongran ^a,b   Li, Chunyan ^a,b  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b Institute of Cardiocerebrovascular Disease   (China)

Author keywords

Amyotrophic lateral sclerosis; Astrogliosis; Immune; Motor neuron; Spinal cord

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; ASTROCYTOSIS; BRAIN CORTEX; BRAIN HOMOGENATE; CELL ULTRASTRUCTURE; CLINICAL FEATURE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; HISTOPATHOLOGY; IMMUNE MEDIATED INJURY; IMMUNOHISTOCHEMISTRY; MALE; MITOCHONDRION SWELLING; MOTOR NEURON DISEASE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD; SPINAL CORD VENTRAL HORN;

ANIMALS; ASTROCYTES; DISEASE MODELS, ANIMAL; GLIAL FIBRILLARY ACIDIC PROTEIN; GUINEA PIGS; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MOTOR NEURON DISEASE; NERVE DEGENERATION;

EID: 34547608163     PISSN: 17482968     EISSN: 1471180X     Source Type: Journal    
DOI: 10.1080/17482960701278612     Document Type: Article

References (12)

1. Engelhardt, J. I., Appel, S. H. and Killian, J. M. (1990) Motor neuron destruction in guinea pigs immunized with bovine spinal cord ventral horn homogenate: Experimental autoimmune grey matter disease. J Neuroimmunol, 27, pp. 21-31.
2. Rothstein, J. D. (1996) Exictotoxicity hypothesis. Neurology, 47, p. S19.
3. Appel, S. H. and Simpson, E. P. (2001) Activated microglia: The silent executioner in neurodegenerative disease?. Curr Neurol Neurosci Rep, 1, pp. 303-305.
4. Nagy, D., Kato, T. and Kushner, P. D. (1994) Reactive astrocytes are widespread in the cortical grey matter of amyotrophic lateral sclerosis. J Neurosci Res, 38, pp. 336-347.
5. Kushner, P. D., Stephenson, D. T. and Wright, S. (1991) Reactive astrogliosis is widespread in the subcortical white matter of amyotrophic lateral sclerosis brain. J Neuropathol Exp Neurol, 50, pp. 263-277.
6. Schiffer, D., Cordera, S., Cavalla, P. and Migheli, A. (1996) Reactive astrogliosis of the spinal cord in amyotrophic lateral sclerosis. J Neurol Sci, 139, pp. 27-33.
7. Araque, A., Martin, E. D., Perea, G., Arellano, J. I. and Buno, W. (2002) Synaptically released acetylcholine evokes Ca2+ elevations in astrocytes in hippocampal slices. J Neurosci, 22, pp. 2443-2450.
8. Hansson, E. and Ronnback, L. (2003) Glial neuronal signalling in the central nervous system. FASEB J, 17, pp. 341-348.
9. Takuma, K., Baba, A. and Matsuda, T. (2004) Astrocyte apoptosis: implications for neuroprotection. Prog Neurobiol, 72, pp. 111-127.
10. Rothstein, J. D., van Kammen, M., Levey, A. I., Martin, L. J. and Kuncl, R. W. (1995) Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann Neurol, 38, pp. 73-84.
11. Volterra, A., Trotti, D., Troma, C., Floridi, S. and Racaqni, G. (1994) Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes. J Neurosci, 14, pp. 2924-2932.
12. Norenberg, M. D. (1994) Astrocyte responses to CNS injury. J Neuropathol Exp Neurol, 53, pp. 213-220.