QT interval prolongation and torsades de pointes due to a coadministration of ciprofloxacin and azimilide in a patient with implantable cardioverter-defibrillator

PACE - Pacing and Clinical Electrophysiology

Volumn 30, Issue 8, 2007, Pages 1043-1046

  Kaźmierczak, Jarosław ^a   Peregud Pogorzelska, Małgorzata ^a   Rzeuski, Ryszard ^a  

^a POMERANIAN MEDICAL UNIVERSITY   (Poland)

Author keywords

Azimilide; Ciprofloxacin; Proarrhythmia; QT interval prolongation; Torsades te pointes

Indexed keywords

AZIMILIDE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CIPROFLOXACIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FUROSEMIDE; MAGNESIUM; METOPROLOL; POTASSIUM; QUINOLONE DERIVATIVE; SPIRONOLACTONE;

ADD ON THERAPY; AGED; ARTICLE; BLOOD ANALYSIS; CASE REPORT; CONGESTIVE HEART FAILURE; DEFIBRILLATOR; DRUG DOSAGE FORM COMPARISON; DRUG DOSE INCREASE; DRUG WITHDRAWAL; ECHOCARDIOGRAPHY; HUMAN; MALE; QT PROLONGATION; SINUS RHYTHM; THORAX RADIOGRAPHY; TORSADE DES POINTES;

AGED; ANTI-ARRHYTHMIA AGENTS; ANTI-INFECTIVE AGENTS; CIPROFLOXACIN; DEFIBRILLATORS, IMPLANTABLE; DRUG INTERACTIONS; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; IMIDAZOLIDINES; LONG QT SYNDROME; PIPERAZINES; TACHYCARDIA, VENTRICULAR; TORSADES DE POINTES;

EID: 34547603505     PISSN: 01478389     EISSN: 15408159     Source Type: Journal    
DOI: 10.1111/j.1540-8159.2007.00809.x     Document Type: Article

References (10)

1. Katritis D, Camm J. Quinolones: Cardioprotective or cardiotoxic? Pacing Clin Eloctrophysiol 2003 26 : 2317 2320.
2. Ball P. Quinolone-induced QT interval prolongation: A not-so-unexpected class effect. J Antimicrob Chemother 2000 45 : 557 559.
3. Kahn JB. Quinolone-induced QT interval prolongation: A not-so-unexpected class effect. J Antimicrob Chemother 2000 46 : 847 848.
4. Patmore L, Fraser S, Mair D, Templeton A. Effects of sparfloxacin, grapafloxacin, moxifloxacin, and ciprofloxacin on cardiac action potential duration. Eur J Pharmacol 2000 406 : 449 452.
5. Frothingham R. Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin. Pharmacotherapy 2001 21 : 1468 1472.
6. Darpo B. Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes. Eur Heart J Suppl 2001 3 (Suppl K K70 K80.
7. Prabhakar M, Krahn AD. Ciprofloxacin-induced acquired long QT syndrome. Heart Rhythm 2004 1 : 624 626.
8. Cooke CE, Sklar GE, Nappi JM. Possible pharmacokinetic interaction with quinidine: Ciprofloxacin or metronidazole? Ann Pharmacother 1996 30 : 364 366.
9. Pratt CM, Al-Khalidi HR, Brum JM, Holroyde M, Schwartz PJ, Marcello SR, Borggrefe M, et al. Cumulative experience of azimilide-associated torsades de pointes ventricular tachycardia in the 19 clinical studies comprising the azimilide database. J Am Coll Cardiol 2006 48 : 471 477.
10. Neapolitano C, Schwartz PJ, Brown AM, Ronchetti E, Bianch L, Pinnavaia A, Acquaro G, et al. Evidence for cardiac ion channel mutation underlying drug-induced QT prolongation and life threatening arrhythmias. J Cardiovasc Electrophysiol 2000 11 : 691 696.