Lymphomatoid granulomatosis and diffuse alveolar damage associated with methotrexate therapy in a patient with rheumatoid arthritis

Clinical Rheumatology

Volumn 26, Issue 9, 2007, Pages 1585-1589

  Kameda, Hideto ^a   Okuyama, Ayumi ^a   Tamaru, Jun Ichi ^b   Itoyama, Shinji ^b   Iizuka, Atsushi ^a   Takeuchi, Tsutomu ^a  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Diffuse alveolar damage; Epstein Barrvirus; Lymphomatoid granulomatosis; Methotrexate; Rheumatoid arthritis

Indexed keywords

ACTARIT; ALANINE AMINOTRANSFERASE; C REACTIVE PROTEIN; CA 15-3 ANTIGEN; CARCINOEMBRYONIC ANTIGEN; COTRIMOXAZOLE; CREATININE; CYCLOPHOSPHAMIDE; DOXORUBICIN; FLUCONAZOLE; GOLD; HEMOGLOBIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; KREBS VON DEN LUNGEN 6; LACTATE DEHYDROGENASE; METHOTREXATE; METHYLPREDNISOLONE; MUCIN 1; NEURON SPECIFIC ENOLASE; PANIPENEM PLUS BETAMIPRON; PREDNISOLONE; PROTEIN; RHEUMATOID FACTOR; SALAZOSULFAPYRIDINE; SOLUBLE INTERLEUKIN 2 RECEPTOR; SQUAMOUS CELL CARCINOMA ANTIGEN; UNCLASSIFIED DRUG; VINCRISTINE;

AGED; ARTHRALGIA; ARTICLE; ARTIFICIAL VENTILATION; AUTOPSY; AXILLARY MASS; B LYMPHOCYTE; CASE REPORT; CONTROLLED STUDY; DRUG DOSE INCREASE; DRUG FATALITY; DRUG PULSE THERAPY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; DYSPNEA; ENDOTRACHEAL INTUBATION; EPSTEIN BARR VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPOXIA; INTERSTITIAL PNEUMONIA; LABORATORY TEST; LUNG INFILTRATE; LUNG INJURY; LUNG PARENCHYMA; LYMPHADENOPATHY; LYMPHOMA; LYMPHOMATOID GRANULOMATOSIS; LYMPHOPROLIFERATIVE DISEASE; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; THORAX RADIOGRAPHY; TREATMENT DURATION; TUMOR BIOPSY; VIRUS DETECTION; VIRUS INFECTION;

AGED; ARTHRITIS, RHEUMATOID; EPSTEIN-BARR VIRUS INFECTIONS; FATAL OUTCOME; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LYMPHOMATOID GRANULOMATOSIS; LYMPHOPROLIFERATIVE DISORDERS; MALE; METHOTREXATE; PNEUMONIA; PULMONARY ALVEOLI;

EID: 34547580840     PISSN: 07703198     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10067-006-0480-2     Document Type: Article

References (19)

1. Pincus T, Ferraccioli G, Sokka T, Larsen A, Rau R, Kushner I, Wolfe F (2002) Evidence from clinical trials and long-term observational studies that disease-modifying anti-rheumatic drugs slow radiographic progression in rheumatoid arthritis: Updating a 1983 review. Rheumatology (Oxford) 41:1346-1356
2. Krause D, Scleusser B, Herborn G, Rau R (2000) Response to methotrexate treatment is associated with reduced mortality in patients with severe rheumatoid arthritis. Arthritis Rheum 43:14-21
3. Searles G, McKendry RJR (1987) Methotrexate pneumonitis in rheumatoid arthritis: Potential risk factors. Four cases reports and a review of the literature. J Rheumatol 14:1164-1171
4. Carson CW, Cannon GW, Egger MJ, Ward JR, Clegg DO (1987) Pulmonary disease during the treatment of rheumatoid arthritis with low dose pulse methotrexate. Semin Arthritis Rheum 16:186-195
5. Carroll GJ, Thomas R, Phatouros CC, Atchison MH, Lesile AL, Cook NJ, D'Souza I (1994) Incidence, prevalence and possible risk factors for pneumonitis in patients with rheumatoid arthritis receiving methotrexate. J Rheumatol 21:51-54
6. Ohosone Y, Okano Y, Kameda H, Fujii T, Hama N, Hirakata M, Mimori T, Akizuki M, Ikeda Y (1997) Clinical characteristics of patients with rheumatoid arthritis and methotrexate induced pneumonitis. J Rheumatol 24:2299-2303
7. Kremer JM, Alarcon GS, Weinblatt ME, Kaymakcian MV, Macaluso M, Cannon GW, Palmer WR, Sundy JS, St. Clair EW, Alexander RW, Smith GJ, Axiotis CA (1997) Clinical, laboratory, radiographic, and histopathologic features of methotrexate-associated lung injury in patients with rheumatoid arthritis: A multicenter study with literature review. Arthritis Rheum 40:1829-1837
8. Cannon GW (1997) Methotrexate pulmonary toxicity. Rheum Dis Clin North Am 23:917-937
9. Imokawa S, Colby TV, Leslie KO, Helmers RA (2000) Methotraxate pneumonitis: Review of the literature and histopathological findings in nine patients. Eur Respir J 15:373-381
10. Gutierrez-Urena S, Molina JF, García CO, Cuéllar ML, Espinoza LR (1996) Pancytopenia secondary to methotrexate therapy in rheumatoid arthritis. Arthritis Rheum 39:272-276
11. Ohosone Y, Okano Y, Kameda H, Hama N, Mimori T, Akizuki M, Ikeda Y (1997) Clinical characteristics related to methotrexate-induced pancytopenia. Clin Rheumatol 16:321-323
12. Georgescu L, Quinn GC, Schwartzman S, Paget SA (1997) Lymphoma in patients with rheumatoid arthritis: Association with the disease state or methotrexate treatment. Semin Arthritis Rheum 26:794-804
13. Feng W-H, Cohen JI, Fischer S, Li L, Sneller M, Goldbach-Mansky R, Raab-Traub N, Delecluse HJ, Kenney SC (2004) Reactivation of latent Epstein-Barr virus by methotrexate: A potential contributor to methotrexate-associated lymphomas. J Natl Cancer Inst 96:1691-1702
14. Baird RD, van Zyl-Smit RN, Dilke T, Scott SE, Rassam SMB (2002) Spontaneous remission of low-grade B-cell non-Hodgkin's lymphoma following withdrawal of methotrexate in a patient with rheumatoid arthritis: Case report and review of the literature. Br J Haematol 118:567-568
15. Ebeo CT, Girish MR, Byrd RP, Roy TM, Mehta JB (2003) Methotrexate-induced pulmonary lymphoma. Chest 123:2150-2153
16. Kohno N (1999) Serum marker KL-6/MUC1 for the diagnosis and management of interstitial pneumonitis. J Med Invest 46:151-158
17. Moder KG, Tefferi A, Cohen MD, Menke DM, Luthra HS (1995) Hematologic malignancies and the use of methotrexate in rheumatoid arthritis: A retrospective study. Am J Med 99:276-281
18. Mariette X, Cazals-Hatem D, Warszawki J, Liote F, Balandraud N, Sibilia J (2002) Lymphoma in rheumatoid arthritis patients treated with methotrexate: A 3-year prospective study in France. Blood 99:3909-3915
19. Wolfe F, Michaud K (2004) Lymphoma in rheumatoid arthritis: The effect of methotrexate and anti-tumor necrosis factor therapy in 18,572 patients. Arthritis Rheum 50:1740-1751