Clastogenicity of quinoline derivatives in the liver micronucleus assay using rats and mice

Journal of Health Science

Volumn 53, Issue 4, 2007, Pages 470-474

  Hakura, Atsushi ^a   Kadoi, Minoru ^b   Suzuki, Takayoshi ^c   Saeki, Ken Ichi ^b  

^a EISAI CO LTD   (Japan)

^b NAGOYA CITY UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Fluoroquinolines; Micronucleus test; Non hepatectomized; Quinolines

Indexed keywords

3 FLUOROQUINOLINE; 5 FLUOROQUINOLINE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CONTROLLED STUDY; LIVER; LIVER CELL; LIVER RESECTION; MALE; MICRONUCLEUS; MICRONUCLEUS TEST; MOUSE; MUTAGENICITY; NONHUMAN; RAT;

ANIMALIA; BACTERIA (MICROORGANISMS); MUS; RATTUS;

EID: 34547567503     PISSN: 13449702     EISSN: 13475207     Source Type: Journal    
DOI: 10.1248/jhs.53.470     Document Type: Article

References (17)

1. Saeki, K., Kadoi, M., Kawazoe, Y., Futakuchi, M., Twawech, D. and Shirai, T. (1997) Modification of the carcinogenic potency of quinoline, a hepatocarcinogen, by fluorine atom substitution: evaluation of carcinogenicity by a médium-term assay. Biol. Pharm. Bull., 20, 40-43.
2. Hirao, N., Shinohara, Y., Tsuda, H., Fukushima, S., Takahashi, M. and Ito, N. (1976) Carcinogenic activity of quinoline on rat liver. Cancer Res., 36, 329-335.
3. Shinohara, Y., Ogiso, T., Hananouchi, M., Nakanishi, K., Yoshimura, T. and Ito, N. (1977) Effects of various factors on the induction of liver tumors in animals by quinoline. Jpn. J. Cancer Res., 68, 785-796.
4. Wayand, E. H., Defauw, J., McQueen, C. A., Meschter, C. L., Meegalla, S. K. and LaVoie, E. J. (1993) Bioassay of quinoline, 5-fluoroquinoline, carbazole, 9-methylcarbazole and 9-ethylcarbazole in newborn mice. Food Chem. Toxicol., 31, 707-715.
5. Nagao, M., Yahagi, T., Seino, Y., Sugimura, T. and Ito, N. (1977) Mutagenicities of quinoline and its derivatives. Mutat. Res., 42, 335-342.
6. Tada, M., Takahashi, K. and Kawazoe, Y. (1982) Binding of quinoline to nucleic acid in a subcelluar microsomal system. Chem.-Biol. Interact., 29, 257-266.
7. Takahashi, K., Kamiya, M., Sengoku, Y., Kohda, K. and Kawazoe, Y. (1988) Deprivation of the mutagenic property of quinoline: Inhibition of mutagenic metabolism by fluorine substitution. Chem. Pharm. Bull., 36, 4630-4633.
8. Miyata, Y., Saeki, K., Kawazoe, Y., Hayashi, M., Sofuni, T. and Suzuki, T. (1998) Antimutagenic structural modification of quinoline assessed by an in vivo mutagenesis assay using lacZ-transgenic mice. Mutat. Res., 414, 165-169.
9. Kato, T., Saeki, K., Kawazoe, Y. and Hakura, A. (1999) Effects of oligofluorine substitution on the mutagenicity of quinoline: a study with twelve fluoroquinoline derivatives. Mutat. Res., 439, 149-157.
10. LaVoie, E. J., Tulley-Freiler, L., Bedenko, V. and Hoffmann, D. (1983) Mutagenicity of substituted phenanthrenes in Salmonella typhinurium. Mutat. Res., 116, 91-102.
11. Hecht, S. S., LaVoie, E. J., Bedenko, V., Pingaro, L., Katayama, S., Hoffmann, D., Sardella, D. J., Boger, E. and Lehr, R. E. (1981) Reduction of tumorigenicity and of dihydrodiol formation by fluorine substitution in the angular rings of dibenzo[a,i]pyrene. Cancer Res., 41, 4341-4345.
12. Hubenman, E. and Slag, T. J. (1979) Mutagenicity and tumor-initiating activity of fluorinated derivatives of 7,12-dimethylbenz[a]anthracene. Cancer Res., 39, 411-414.
13. Diamond, L., Chain, K., Harvey, R. G. and DiGiovanni, J. (1984) Mutagenic activity of methyl- and fluoro-substituted derivatives of polycyclic aromatic hydrocarbons in a human hepatoma cell-mediated assay. Mutat. Res., 136, 65-72.
14. Parton, J. W. and Garriott, M. L. (1997) An evaluation of micronucleus induction in bone marrow and in hepatocytes isolated from collagenase perfused liver or from formalin-fixed liver using four-week-old rats treated with known clastogens. Environ. Mol. Mutagen., 29, 379-385.
15. Suzuki, H., Ikeda, N., Kobayashi, K., Terashima, Y., Shimada, Y., Suzuki, T., Hagiwara, T., Hatakeyama, S., Nagaoka, K., Yoshida, J., Saito, Y., Tanaka, J. and Hayashi, M. (2005) Evaluation of liver and peripheral blood micronucleus assays with 9 chemicals using young rats: A study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS). Mutat. Res., 583, 133-145.
16. Saeki, K., Kadoi, M., Kawazoe, Y., Igarashi, M. and Shimada, H. (2000) Clastogenicity of quinoline derivatives tested by micronucleus induction in vivo in the hepatocytes od partially hepatectomized mice. Biol. Pharm. Bull., 23, 219-221.
17. Tada, M., Takahashi, K. and Kawazoe, Y. (1982) Metabolism of quinoline, a hepatocarcinogen, in a subcellular microsomal system. Chem. Pharm. Bull., 30, 3834-3837.