Effect of vascular endothelial growth factor 165 gene transfection on bone defects and its mRNA expression in rabbits

Chinese Medical Journal

Volumn 120, Issue 13, 2007, Pages 1187-1191

  Zhao, Dong Mei ^a   Wang, Hai Bin ^a   Yang, Jia Feng ^a   Wu, Shi Qing ^a   Liu, Jun Li ^a   Xu, Fu Yu ^a   Qiu, Li Ping ^a   Cai, Jing Long ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Bone deects; Gene transfection; Vascular endothelial growth factor

Indexed keywords

COMPLEMENTARY DNA; GELATIN SPONGE; MESSENGER RNA; PLASMID DNA; SODIUM CHLORIDE; VASCULOTROPIN 165;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEFECT; BONE DEVELOPMENT; BONE RADIOGRAPHY; CALLUS; CELL PROLIFERATION; CONTROLLED STUDY; CORTICAL BONE; GENE EXPRESSION; GENETIC TRANSFECTION; MICROSCOPY; NONHUMAN; NONVIRAL GENE THERAPY; OSTEOBLAST; RABBIT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION; RNA EXTRACTION; SYNOSTOSIS; UPREGULATION;

EID: 34547516900     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200707010-00015     Document Type: Article

References (18)

1. Yang JF, Cai JL, WANG LL, Qiu LP, Xue AY, Yan HS. Experimental Study on Polymer Artificial Bone with HA Coated and Fiber liners. J Wuhan Univ Technol-Mater Sci (Chin) 2005; 21 (suppl): 144-146.
2. Kofron MD, Laurencin CT. Bone tissue engineering by gene delivery. Adv Drug Deliv Rev 2006; 58: 555-576.
3. Zhang D, Gai L, Fan R, Dong W, Wen Y. Efficacy and safety of therapeutic angiogenesis from direct myocardial administration of an adenoviral vector expressing vascular endothelial growth factor 165. Chin Med J 2002; 115: 643-648.
4. 165 gene: an experimental study with mice. Natl Med J Chin (Chin) 2005; 85: 473-478.
5. Yang C, Yang S, Du J, Li J, Xu W, Xiong Y. Vascular endothelial growth factor gene transfection to enhance the repair of avascular necrosis of the femoral head of rabbit. Chin Med J 2003; 116: 1544-1548.
6. Zhang Z, Dong H, Liu J, Wang W, Hu B. Vascular endothelial growth factor gene transfer improves host endothelialization of xenogeneic biologic heart valve in vivo. Chin Med J 2002; 115: 878-883.
7. Guan H, Zhou Z, Wang H, Jia SF, Liu W, Kleinerman ES. A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model. Clin Cancer Res 2005; 11: 2662-2669.
8. Iwaguro H, Yamaguchi J, Kalka C, Murasawa S, Masuda H, Hayashi S, et al. Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration. Circulation 2002; 105: 732-738.
9. Tian YY, Sun SG, Wang JN, Tang CJ, Feng Y, Wang L, et al. Adenovirus mediated vascular endothelial growth factor gene transfer protects dopaminergic neurons in Parkinson's disease: experiment with rat. Natl Med J Chin (Chin) 2006; 86: 2054-2059.
10. 165 -GAM) enhances osteogenesis and angiogenesis in large segmental bone defects. J Bone Miner Res 2005; 20: 2028-2035.
11. 165 recombined vector on wound healing and the expression of collagen type I, III mRNA in wounded tissue. Chin J Plast Surg (Chin) 2006; 22: 461-464.
12. Liu HC, Cheng H, Tirunagaru V, Sofer L, Burnside J. A strategy to identify positional candidate genes conferring Marek's disease resistance by integrating DNA micro arrays and genetic mapping. Animal Geneties 2001; 32: 351-359.
13. Smythe LD, Smith IL, Smith GA, Dohnt MF, Symonds ML, Barnett LJ, et al. A quantitative PCR (TaqMan) essay for pathogenic Leptospiraspp. BMC Infectious Diseases 2002; 2: 13-19.
14. Baltzer AW, Lattermann C, Whalen JD, Ghivizzani S, Wooley P, Krauspe R, et al. Potential role of direct adenoviral gene transfer in enhancing fracture repair. Clin Orthop Rel Res 2000; 379 (Suppl): S120-125.
15. Baltzer AW, Lattermann C, Whalen JD, Wooley P, Weiss K, Grimm M, et al. Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene. Gene Ther 2000; 7: 734-739.
16. Yu SH, Ye XD, Shou L. The therapy with VEGF gene for ischemic TRAM flap in rats. Chin J Plast Surg (Chin) 2003; 19: 373-376.
17. Franceschi RT. Biological Approaches to Bone Regeneration by Gene Therapy. J Dent Res 2005; 84: 1093-1103.
18. 165 recombined vector on bone defects. Chin J Orthop (Chin) 2006; 26: 769-772.