Quinazoline derivatives as MC-I inhibitors: Evaluation of myocardial uptake using Positron Emission Tomography in rat and non-human primate

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 17, 2007, Pages 4882-4885

  Purohit, Ajay ^a   Benetti, Richard ^b   Hayes, Megan ^a   Guaraldi, Mary ^a   Kagan, Mikhail ^a   Yalamanchilli, Padmaja ^a   Su, Fran ^c   Azure, Michael ^a   Mistry, Mahesh ^a   Yu, Ming ^a   Robinson, Simon ^a   Dischino, Douglas D ^a   Casebier, David ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NEW YORK UNIVERSITY   (United States)

Author keywords

MC I inhibitors; Myocardial perfusion; Positron Emission Tomography; Quinazoline derivatives

Indexed keywords

FLUORODEOXYGLUCOSE F 18; OXIDOREDUCTASE INHIBITOR; QUINAZOLINE DERIVATIVE; UBIQUINOL CYTOCHROME C REDUCTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG METABOLISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HEART MUSCLE; IC 50; LIVER CLEARANCE; MONKEY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT;

ANIMALS; DRUG EVALUATION, PRECLINICAL; ELECTRON TRANSPORT COMPLEX I; HEART; INHIBITORY CONCENTRATION 50; LIVER; MODELS, CHEMICAL; POSITRON-EMISSION TOMOGRAPHY; PRIMATES; QUINAZOLINES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

PRIMATES; RATTUS;

EID: 34547516593     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.06.043     Document Type: Article

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