Size of sentinel node tumor deposits and extent of axillary lymph node involvement: Which breast cancer patients may benefit from less aggressive axillary dissections?

Annals of Surgical Oncology

Volumn 14, Issue 8, 2007, Pages 2221-2227

  Samoilova, Elena ^a   Davis, Joseph T ^a   Hinson, Jeffrey ^a   Brill, Yolanda M ^a   Cibull, Michael L ^a   McGrath, Patrick ^a   Romond, Edward ^a   Moore, Angela ^a   Samayoa, Luis M ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b LEXINGTON VA MEDICAL CENTER   (United States)

Author keywords

Conservative axillary dissection; Minimal axillary disease; Sentinel node; Size of tumor deposits

Indexed keywords

BREAST CANCER; CANCER GRADING; CANCER LOCALIZATION; CANCER RISK; CANCER SIZE; CANCER STAGING; CONTROLLED STUDY; DISEASE CONTROL; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; REVIEW; SENTINEL LYMPH NODE BIOPSY; STATISTICAL SIGNIFICANCE;

AXILLA; BREAST NEOPLASMS; FEMALE; HISTOCYTOCHEMISTRY; HUMANS; LYMPH NODE EXCISION; LYMPHATIC METASTASIS; NEOPLASM STAGING; PATIENT SELECTION; RETROSPECTIVE STUDIES; SENTINEL LYMPH NODE BIOPSY; TUMOR BURDEN;

EID: 34547465575     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-007-9458-9     Document Type: Review

References (47)

1. Giuliano AE, Kirgan DM, Guenther JM, Morton DL. Lymphatic mapping and sentinel lymphadenectomy for breast cancer. Ann Surg 1994;220:391-8
2. Krag D, Weaver D, Ashikaga T, et al. The sentinel node in breast cancer-a multicenter validation study. N Engl J Med 1998;339:941-6
3. Chu KU, Turner RR, Hansen NM, Brennan MB, Giuliano AE. Sentinel node metastasis in patients with breast carcinoma accurately predicts immunohistochemically detectable nonsentinel node metastasis. Ann Surg Oncol 1999;6:756-61
4. Sachdev U, Murphy K, Derzie A, et al. Predictors of non-sentinel lymph node metastasis in breast cancer patients. Am J Surg 2003;183:213-7
5. Reynolds C, Mick R, Donohue JH, et al. Sentinel node biopsy with metastasis: can axillary dissection be avoided in some patients with breast cancer. J Clin Oncol 1999;17:1720-6
6. Turner RR, Chu KU, Qi K, et al. Pathologic features associated with nonsentinel lymph node metastases in patients with metastatic breast carcinoma in a sentinel lymph node. Cancer 2000;89:574-81
7. Kamath VJ, Giuliano R, Dauway EL, et al. Characteristics of the sentinel lymph node in breast cancer predict further involvement of higher-echelon nodes in the axilla: a study to evaluate the need for complete axillary lymph node dissection. Arch Surg 2001;136:688-92
8. Rutledge H, Davis J, Chiu R, et al. Sentinel node micrometastasis in breast carcinoma may not be an indication for complete axillary dissection. Mod Pathol 2005;18:762-8
9. Samayoa LM, Witzke D, Sloan D, et al. Defining sentinel lymph nodes in breast carcinoma. Mod Pathol 2001;14:189
10. Degnim A, Reynolds C, Pantvaidya G, et al. Non-sentinel node metastasis in breast cancer patients: assessment of an existing and a new predictive nomogram. Am J Surg 2005;190:543-50
11. Schulze T, Mucke J, Markwardt J, et al. Long-term morbidity of patients with early breast cancer after sentinel lymph node biopsy compared to axillary lymph node dissection. J Surg Oncol 2006;93:109-19
12. Burak WE, Hollenbeck ST, Zervos EE, et al. Sentinel lymph node biopsy results in less postoperative morbidity compared with axillary lymph node dissection for breast cancer. Curr Surg 2004;61:259-63
13. Petrek JA, Heelan MC. Incidence of breast carcinoma-related lymphedema. Cancer Suppl 1998;83:2776-81
14. Geller BM, Vacek PM, O'Brien P, Secker-Walker RH. Factors associated with arm swelling after breast cancer surgery. J Womens Health 2003;12:921-30
15. Voogd AC, Ververs JM, Vingerhoets AJ, Roumen RM, Coebergh JW, Crommelin MA. Lymphoedema and reduced shoulder function as indicators of quality of life after axillary lymph node dissection for invasive breast cancer. Br J Surg 2003;90:76-81
16. Morrell RM, Halyard MY, Schild SE, Ali MS, Gunderson LL, Pockaj BA. Breast cancer-related lymphedema. Mayo Clin Proc 2005;80:1480-4
17. Armer JM. The problem of post-breast cancer lymphedema: impact and measurement issues. Cancer Invest 2005;23:76-83
18. Engel J, Kerr J, Schlesinger-Raab A, Sauer H, Holzel D. Axilla surgery severely affects quality of life: results of a 5-year prospective study in breast cancer patients. Breast Cancer Res Treat 2003;80:233
19. Carcoforo P, Maestroni U, Querzoli P, et al. Primary breast cancer features can predict additional lymph node involvement in patients with sentinel node micrometastases. World J Surg 2006;30:1653-7
20. Maffuz A, Barroso-Bravo S, Najera I, Zarco G, Alvarado-Cabrero I, Rodriguez-Cuevas SA. Tumor size as predictor of microinvasion, invasion, and axillary metastasis in ductal carcinoma in situ. J Exp Clin Cancer Res 2006;25:223-7
21. Ozmen V, Karanlik H, Cabioglu N, et al. Factors predicting the sentinel and non- sentinel lymph node metastases in breast cancer. Breast Cancer Res Treat 2006;95:1-6
22. Wada N, Imoto S, Yamauchi C, Hasebe T, Ochiai A. Predictors of tumour involvement in remaining axillary lymph nodes of breast cancer patients with positive sentinel lymph node. Eur J Surg Oncol 2006;32:29-33
23. Yu JC, Hsu GC, Hsieh CB, Sheu LF, Chao TY. Prediction of metastasis to non-sentinel nodes by sentinel node status and primary tumor characteristics in primary breast cancer in Taiwan. World J Surg 2005;7:813-8
24. Cao Y, Paner GP, Rajan PB. Sentinel node status and tumor characteristics: a study of 234 invasive breast carcinomas. Arch Pathol Lab Med 2005;129:82-4
25. Viale G, Zurrida S, Maiorano E, et al. Predicting the status of axillary sentinel lymph nodes in 4351 patients with invasive breast carcinoma treated in a single institution. Cancer 2005;103:492-500
26. Goyal A, Douglas-Jones A, Newcombe RG, Mansel RE, ALMANAC Trialists Group. Predictors of non-sentinel lymph node metastasis in breast cancer patients. Eur J Cancer 2004;40:1731-7
27. Joseph KA, El-Tamer M, Komenaka I, Troxel A, Ditkoff BA, Schnabel F. Predictors of nonsentinel node metastasis in patients with breast cancer after sentinel node metastasis. Arch Surg 2004;139:648-51
28. Saidi RF, Dudrick PS, Remine SG, Mittal VK. Nonsentinel lymph node status after positive sentinel lymph node biopsy in early breast cancer. Am Surg 2004;70:101-5
29. van Iterson V, Leidenius M, Krogerus L, von Smitten K. Predictive factors for the status of non-sentinel nodes in breast cancer patients with tumor positive sentinel nodes. Breast Cancer Res Treat 2003;82:39-45
30. Degnim AC, Griffith KA, Sabel MS, et al. Clinicopathologic features of metastasis in nonsentinel lymph nodes of breast carcinoma patients. Cancer 2003;98:2307-15
31. Hwang RF, Krishnamurthy S, Hunt KK, et al. Clinicopathologic factors predicting involvement of nonsentinel axillary nodes in women with breast cancer. Ann Surg Oncol 2003;10:248-54
32. Chen M, Palleschi S, Khoynezhad A, Gecelter G, Marini CP, Simms HH. Role of primary breast cancer characteristics in predicting positive sentinel lymph node biopsy results: a multivariate analysis. Arch Surg 2002;137:606-9
33. Silverstein MJ, Skinner KA, Lomis TJ. Predicting axillary nodal positivity in 2282 patients with breast carcinoma. World J Surg 2001;25:767-72
34. Beenken SW, Urist MM, Zhang Y, et al. Axillary lymph node status, but not tumor size, predicts locoregional recurrence and overall survival after mastectomy for breast cancer. Ann Surg 2003:237:732-8
35. Travagli JP, Atallah D, Mathieu MC, et al. Sentinel lymphadenectomy without systematic axillary dissection in breast cancer patients: predictors of non-sentinel lymph node metastasis. Eur J Surg Oncol 2003;29:403-6
36. Lee AH, Pinder SE, Macmillan RD, et al. Prognostic value of lymphovascular invasion in women with lymph node negative invasive breast carcinoma. Eur J Cancer 2006;42:357-62
37. Tan YY, Wu CT, Fan YG, et al. Primary tumor characteristics predict sentinel lymph node macrometastasis in breast cancer. Breast J 2005;11:338-43
38. Callejo IP, Brito JA, Bivar JW, et al. Predictors of positive axillary lymph nodes in breast cancer patients with metastatic sentinel lymph node. Clin Transl Oncol 2005;7:18-22
39. Viale G, Maiorano E, Pruneri G, et al. Predicting the risk for additional axillary metastases in patients with breast carcinoma and positive sentinel lymph node biopsy. Ann Surg 2005;241:319-25
40. Katz A, Niemierko A, Gage I, et al. Can axillary dissection be avoided in patients with sentinel lymph node metastasis? J Surg Oncol 2006;93:550
41. Zavagno G, De Salvo GL, Bozza F, et al. Number of metastatic sentinel nodes as predictor of axillary involvement in patients with breast cancer. Breast Cancer Res Treat 2004;86:171-9
42. Abdessalam SF, Zervos EE, Prasad M, et al. Predictors of positive axillary lymph nodes after sentinel lymph node biopsy in breast cancer. Am J Surg 2001;182:316-20
43. Chu KU, Turner RR, Hansen NM, Brennan MB, Bilchik A, Giuliano AE. Do all patients with sentinel node metastasis from breast carcinoma need complete axillary node dissection? Ann Surg 1999;229:536-41
44. Weiser MR, Montgomery LL, Tan LK, et al. Lymphovascular invasion enhances the prediction of non-sentinel node metastases in breast cancer patients with positive sentinel nodes. Ann Surg Oncol 2001;8:145-9
45. Chagpar AB, Scoggins CR, Martin RC, et al. Prediction of sentinel lymph node-only disease in women with invasive breast cancer. Am J Surg 2006;192:882-7
46. Chagpar AB, Scoggins CR, Martin RC, et al. Predicting patients at low probability of requiring postmastectomy radiation therapy. Ann Surg Oncol 2007;14:670-7
47. Bevilacqua JL, Cody HS III, MacDonald KA, Tan LK, Borgen PI, Van Zee KJ. A model for predicting axillary node metastases based on 2000 sentinel node procedures and tumour position. EJSO 2002;28:490-500