Protective effects of breviscapine against cultured rat hippocampal neuronal toxicity induced by glutamate

Yaoxue Xuebao

Volumn 42, Issue 6, 2007, Pages 583-588

  Xu, Xiao Hong ^a   Chen, Yu ^b   Zheng, Xiao Xiang ^b  

^a ZHEJIANG NORMAL UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Apoptosis; Breviscapine; Ca2+; Glutamate; X chromosome linked inhibitor of apoptosis protein

Indexed keywords

BREVISCAPINE; CALCIUM; FLAVONOID; GLUTAMIC ACID; MESSENGER RNA; NEUROPROTECTIVE AGENT; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL; APOPTOSIS; ARTICLE; CELL CULTURE; CYTOLOGY; DRUG EFFECT; GENETICS; HIPPOCAMPUS; METABOLISM; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; CALCIUM; CELLS, CULTURED; FLAVONOIDS; GLUTAMIC ACID; HIPPOCAMPUS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 34547450731     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Choi DW. Excitotoxic cell death [J]. J Neurobiol, 1992,23:1261-1276.
2. Trapp T, Korhonen L, Besselmann M, et al. Transgenic mice overexpressing XIAP in neurons show better outcome after transient cerebral ischemia [J]. Mol Cell Neurosci, 2003,23:302-313.
3. Xu D, Bureau Y, McIntyre DC, et al. Attenuation of ischemia-induced cellular and behavioral deficits by X-chromosome-linked inhibitor of apoptosis protein overexpression in the rat hippocampus [J]. J Neurosci, 1999,19:5026-5033.
4. Korhonen L, Belluardo N, Lindholm D. Regulation of X chromosome-linked inhibitor of apoptosis protein in kainic acid induced neuronal death in the rat hippocampus [J]. Mol Cell Neurosci, 2001,17:364-372.
5. Lin X, Chu KD. Progress of pharmacological study on breviscapine [J]. Strait Pharm J, 2005, 17:5-8.
6. Zhang XB, Peng DY, Zhu MF, et al. Protective effect of breviscapine dropping pill against focal cerebral ischemia reperfusion injury in rats [J]. J Anhui Tradit Chin Med Coll, 2003,22:45-47.
7. Li XL, Ying QL, Yan WM, et al. The study of cardioprotective effect of breviscapine during hypoxia of cardiomyocyte in vitro and during myocardial infarction in vivo [J]. Planta Med, 2004,70:1039-1044.
8. Zhang Y, Chen Q, Gu WD, et al. Effects of erigeron on the release of excitatory amino-acids of hippocampus and learning-memory activity after ischemia-reperfusion injury in gerbils [J]. Chin J Pract Chin Mod Med , 2004,4:1930-1932.
9. 2+ in cultured hippocampal neurons [J]. Acta Biochim Biophys Sin , 2003,35:561-566.
10. Sohu S, Kim EY, Gwag BJ. Glutamate neurotoxicity in mouse cortical neurons: a typical necrosis with DNA ladders and chromatin condensation [J]. Neurosci Lett, 1998,240:147-150.
11. Hirashima Y, Kurimoto M, Nogami K, et al. Correlation of glutamate-induced apoptosis with caspase activities in cultured rat cerebral cortical neurons [J]. Brain Res, 1999,849:109-118.
12. Rossi DJ, Oshima T, Attwell D. Glutamate release in severe brain ischemia is mainly by reversed uptake [J]. Nature, 2000,403:316-321.
13. Zhang Y, Chen Q, Gu W, et al. Effects of erigeron on ATP content and release of excitatory amino-acids of the hippocampus after cerebral ischemia/reperfusion injury in gerbils [J]. Jiangsu Med J, 2005,31: 843-846.
14. Peng HD, Tu JW, Tian J. Effects of breviscapine on contents of water and calcium of brain after cerebral ischemia reperfusion in rats [J]. J Hubei Coll Tradit Chin Med, 2002,4:22-23.
15. Wang LJ, Wang Y, Qiu LP, et al. Inhibition of breviscapine to calcium current in single ventricular cells of guinea pigs [J]. Chin J Mod Appl Pharm , 2000,17:272-274.
16. Li WY, Xu XY, Li FQ, et al. The effects of scutellarein on platelet cytosolic free calcium concentration, platelet aggregation rate, and heart remodeling in rats [J]. Chin New Drugs J, 2004,13:220-223.
17. Xu G, Zhang LP, Shen HF, et al. Inhibition of protein kinase C by scutellarein and its analogues [J]. Acta Acad Med Shanghai, 1993,20: 189-191.
18. Dargusch R, Piasecki D, Tan S, et al. The role of Bax in glutamate-induced nerve cell death [J]. J Neurochem, 2001,76:295-301.
19. Tang XS. Breviscapine for the intervention of apoptosis-related protein in rats following cerebral ischemia-reperfusion [J]. Chin J Clin Rehabil, 2005,9:130-131.
20. Xu XH, Zhang SM, Yan WM, et al. Development of cerebral infarction, apoptotic cell death and expression of X-chromosome-linked inhibitor of apoptosis protein following focal cerebral ischemia in rats [J]. Life Sci, 2006,78:704-712.