Effect of various immunosuppressive monotherapies on survival and histopathology of monkey islet xenografts in rats

Xenotransplantation

Volumn 14, Issue 4, 2007, Pages 316-322

  Balamurugan, A N ^a,b   Nelson, Everette J R ^a,c   Ramakrishna, Banumathi ^a   Gunasekaran, S ^a  

^a CHRISTIAN MEDICAL COLLEGE   (India)

^b UNIVERSITY OF COLORADO DENVER   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Dextran density gradients; Diabetes; Immunosuppressive drugs; Islets, monkey; Rats, diabetic; Xenotransplantation

Indexed keywords

COLLAGENASE; CYCLOSPORIN A; DEXTRAN; IMMUNOSUPPRESSIVE AGENT; PREDNISOLONE; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DENSITY; CELL INFILTRATION; CELL SURVIVAL; CONTROLLED STUDY; DIGESTION; DRUG MEGADOSE; FEMALE; GLUCOSE BLOOD LEVEL; GRAFT REJECTION; HISTOLOGY; HISTOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; ISOLATION PROCEDURE; KIDNEY CAPSULE; MALE; MONITORING; MONKEY; MONOTHERAPY; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; SURVIVAL; THERAPY EFFECT; XENOGRAFT;

ANIMALS; BLOOD GLUCOSE; CYCLOSPORINE; DIABETES MELLITUS; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; ISLETS OF LANGERHANS TRANSPLANTATION; MACACA RADIATA; PREDNISOLONE; RATS; TACROLIMUS; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HETEROLOGOUS;

EID: 34547435743     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2007.00409.x     Document Type: Article

References (40)

1. White SA, James RF, Swift SM et al. Human islet cell transplantation - future prospects. Diabet Med 2001 18 : 78 103.
2. Shapiro AM, Ricordi C, Hering BJ et al. International trial of the Edmonton protocol for islet transplantation. N Engl J Med 2006 355 : 1318 1330.
3. Hakim NS. Recent developments and future prospects in pancreatic and islet transplantation. Diabetes Obes Metab 2001 3 : 9 15.
4. Gaur LK. Nonhuman primate models for islet transplantation in type 1 diabetes research. ILAR J 2004 45 : 324 333.
5. Sullivan SJ. Allotransplantation of canine pancreatic islets. Biomed Pharmacother 1992 46 : 385 391.
6. Kim SJ, Joh JW, Lee SK et al. Pancreatic islet cell autotransplantation in the canine model. Transplant Proc 2000 32 : 2473 2474.
7. Mackenzie DA, Hullett DA, Sollinger HW. Xenogeneic transplantation of porcine islets: an overview. Transplantation 2003 76 : 887 891.
8. Rood PP, Buhler LH, Bottino R et al. Pig-to-nonhuman primate islet xenotransplantation: a review of current problems. Cell Transplant 2006 15 : 89 104.
9. Rastellini C, Carroll PB, Rilo HR et al. Baboon pancreatic islet isolation and transplantation. Transplant Proc 1994 26 : 3428 3429.
10. Rastellini C, Behboo R, Rilo HL et al. Functional evaluation of isolated islets from baboon pancreata. Transplant Proc 1995 27 : 3385 3386.
11. Ranuncoli A, Cautero N, Ricordi C et al. Islet cell transplantation: in vivo and in vitro functional assessment of nonhuman primate pancreatic islets. Cell Transplant 2000 9 : 409 414.
12. Contreras JL, Eckhoff DE, Cartner S et al. Long-term functional islet mass and metabolic function after xenoislet transplantation in primates. Transplantation 2000 69 : 195 201.
13. Adams AB, Shirasugi N, Durham MM et al. Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates. Diabetes 2002 51 : 265 270.
14. Xu H, Elster EA, Blair PJ et al. Effects of combined treatment with CD25- and CD154-specific monoclonal antibodies in non-human primate allotransplantation. Am J Transplant 2003 3 : 1350 1354.
15. Hering BJ, Wijkstrom M, Graham ML et al. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med 2006 12 : 301 303.
16. Cardona K, Korbutt GS, Milas Z et al. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Nat Med 2006 12 : 304 306.
17. Komoda H, Miyagawa S, Omori T et al. Survival of adult islet grafts from transgenic pigs with N-acetylglucosaminyltransferase-III (GnT-III) in cynomolgus monkeys. Xenotransplantation 2005 12 : 209 216.
18. Jaeger C, Wohrle M, Federlin K et al. Pancreatic islet xenografts at two different transplantation sites (renal subcapsular versus intraportal): comparison of graft survival and morphology. Exp Clin Endocrinol Diabetes 1995 103 (suppl 2 123 128.
19. Goto M, Groth CG, Nilsson B et al. Intraportal pig islet xenotransplantation into athymic mice as an in vivo model for the study of the instant blood-mediated inflammatory reaction. Xenotransplantation 2004 11 : 195 202.
20. Schrem H, Luck R, Becker T et al. Update on liver transplantation using cyclosporine. Transplant Proc 2004 36 : 2525 2531.
21. Zuckermann A, Klepetko W. Use of cyclosporine in thoracic transplantation. Transplant Proc 2004 36 (suppl 2 331S.
22. Patel JK, Kobashigawa JA. Cardiac transplant experience with cyclosporine. Transplant Proc 2004 36 (suppl 2 323S.
23. Ponticelli C. Cyclosporine: from renal transplantation to autoimmune diseases. Ann N Y Acad Sci 2005 1051 : 551 558.
24. Crespo-Leiro MG. Tacrolimus in heart transplantation. Transplant Proc 2003 35 : 1981 1983.
25. First MR. Tacrolimus based immunosuppression. J Nephrol 2004 17 (suppl 8 S25 S31.
26. Busuttil RW, Lake JR. Role of tacrolimus in the evolution of liver transplantation. Transplantation 2004 77 (suppl 9 S44 S51.
27. Reichenspurner H. Overview of tacrolimus-based immunosuppression after heart or lung transplantation. J Heart Lung Transplant 2005 24 : 119 130.
28. Thomson NM. Corticosteroid agents in renal disease. Med J Aust 1987 146 : 530 531, 534 535, 538.
29. Jorga A, Johnston A. Novel therapies in transplantation. Expert Opin Investig Drugs 2005 14 : 295 304.
30. Balamurugan AN, Ramakrishna B, Gunasekaran S. Optimization of culture conditions for the preservation of monkey pancreatic islets in culture. Pancreas 1999 19 : 83 88.
31. Balamurugan AN, Ramakrishna B, Gunasekaran S. Insulin secretory characteristics of monkey pancreatic islets: a simple method of islet isolation and the effect of various density gradients on separation. Diabetes Res Clin Pract 2004 66 : 13 21.
32. Sullivan FP, Ricordi C, Hauptfeld V et al. Effect of low-temperature culture and site of transplantation on hamster islet xenograft survival (hamster to mouse). Transplantation 1987 44 : 465 468.
33. Lacy PE, Ricordi C, Finke EH. Effect of transplantation site and alpha L3T4 treatment on survival of rat, hamster, and rabbit islet xenografts in mice. Transplantation 1989 47 : 761 766.
34. Leow CK, Gray DW, Morris PJ. The long-term metabolic function of intraportal and renal subcapsular islet isografts and the effect on glomerular basement membrane thickness in rats. Diabetologia 1995 38 : 1014 1024.
35. Jaeger C, Wohrle M, Bretzel RG et al. Effect of transplantation site and culture pretreatment on islet xenograft survival (rat to mouse) in experimental diabetes without immunosuppression of the host. Acta Diabetol 1994 31 : 193 197.
36. Simeonovic CJ. Xenogeneic islet transplantation. Xenotransplantation 1999 6 : 1 5.
37. Nakajima Y, Kessler M, Nakano H et al. Restoration of T cell responsiveness to interleukin-2 in recipients of pancreatic islet xenografts treated with cyclosporine. Transplantation 1985 40 : 73 76.
38. Terasaka R, Lacy PE, Bucy RP et al. Effect of cyclosporine and low-temperature culture on prevention of rejection of islet xenografts (rat-to-mouse). Transplantation 1986 41 : 661 662.
39. Wennberg L, Wallgren AC, Karlsson-Parra A et al. Efficacy of various immunosuppressive drugs in preventing pig-to-rat islet xenograft rejection. Transplant Proc 1995 27 : 266 267.
40. Tze WJ, Tai J, Cheung SS et al. Immunohistochemical studies of pig islet xenograft in rats immunosuppressed with FK 506. Transplant Proc 1994 26 : 768 769.