Induction of anti-carbonic-anhydrase-II antibody causes renal tubular acidosis in a mouse model of Sjögren's syndrome

Nephron - Physiology

Volumn 106, Issue 4, 2007, Pages

  Takemoto, Fumi ^a   Katori, Hideyuki ^a   Sawa, Naoki ^a   Hoshino, Junichi ^a   Suwabe, Tatsuya ^a   Sogawa, Yoko ^a   Nomura, Kazufumi ^a   Nakanishi, Shohei ^a   Higa, Yasushi ^a   Kanbayashi, Hiroshi ^a   Kosuga, Masahiro ^b   Sasaki, Michiko ^b   Tomioka, Satoru ^b   Yamashita, Masahiro ^b   Ubara, Yoshifumi ^a   Yamada, Akira ^a   Takaichi, Kenmei ^a   Uchida, Shunya ^b  

^a TORANOMON HOSPITAL   (Japan)

^b TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Antibody; Carbonic anhydrase II; Renal tubular acidosis; Sj gren's syndrome; Urine pH

Indexed keywords

ADJUVANT; AMMONIUM CHLORIDE; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE II ANTIBODY; ENZYME ANTIBODY; PHOSPHATE BUFFERED SALINE; UNCLASSIFIED DRUG;

ACIDIFICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY TITER; ARTICLE; BLOOD PH; CELL INFILTRATION; CONTROLLED STUDY; FEMALE; IMMUNIZATION; KIDNEY; KIDNEY TUBULE ACIDOSIS; LYMPHOCYTIC INFILTRATION; MALE; METABOLIC ACIDOSIS; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOGENESIS; PLASMA CELL; PRIORITY JOURNAL; SALIVARY GLAND; SJOEGREN SYNDROME; URINE PH;

ACIDOSIS, RENAL TUBULAR; ANIMALS; ANTIGENS; CARBONIC ANHYDRASE II; DISEASE MODELS, ANIMAL; MICE; SJOGREN'S SYNDROME;

EID: 34547417528     PISSN: 16602137     EISSN: None     Source Type: Journal    
DOI: 10.1159/000104873     Document Type: Article

References (17)

1. Fox RI: Sjogren's syndrome. Lancet 2005;366:321-331.
2. Shioji R, Furuyama T, Onodera S, Saito H, Ito H, Sasaki Y: Sjogren's syndrome and renal tubular acidosis. Am J Med 1970;48:456-463.
3. Talal N: Sjogren's syndrome, lymphoproliferation, and renal tubular acidosis. Ann Intern Med 1971;74:633-634.
4. 3 muscarinic acetylcholine receptors in patients with primary Sjogren's syndrome. Invest Ophthalmol Vis Sci 1998;39:151-156.
5. Bacman SR, Berra A, Sterin-Borda L, Borda ES: Human primary Sjogren's syndrome autoantibodies as mediators of nitric oxide release coupled to lacrimal gland muscarinic acetylcholine receptors. Curr Eye Res 1998;17:1135-1142.
6. Waterman SA, Gordon TP, Rischmueller M: Inhibitory effects of muscarinic receptor autoantibodies on parasympathetic neurotransmission in Sjogren's syndrome. Arthritis Rheum 2000;43:1647-1654.
7. Inagaki Y, Jinno-Yoshida Y, Hamasaki Y, Ueki H: A novel autoantibody reactive with carbonic anhydrase in sera from patients with systemic lupus erythematosus and Sjogren's syndrome. J Dermatol Sci 1991;2:147-154.
8. Kino-Ohsaki J, Nishimori I, Morita M, Okazaki K, Yamamoto Y, Onishi S, Hollingsworth MA: Serum antibodies to carbonic anhydrase I and II in patients with idiopathic chronic pancreatitis and Sjogren's syndrome. Gastroenterology 1996;110:1579-1586.
9. Maren TH: Carbonic anhydrase: chemistry, physiology, and inhibition. Physiol Rev 1967;47:595-781.
10. Lonnerholm G, Ridderstrale Y: Intracellular distribution of carbonic anhydrase in the rat kidney. Kidney Int 1980;17:162-174.
11. Takemoto F, Hoshino J, Sawa N, Tamura Y, Tagami T, Yokota M, Katori H, Yokoyama K, Ubara Y, Hara S, Takaichi K, Yamada A, Uchida S: Autoantibodies against carbonic anhydrase II are increased in renal tubular acidosis associated with Sjogren syndrome. Am J Med 2005;118:181-184.
12. Nishimori I, Bratanova T, Toshkov I, Caffrey T, Mogaki M, Shibata Y, Hollingsworth MA: Induction of experimental autoimmune sialoadenitis by immunization of PL/J mice with carbonic anhydrase II. J Immunol 1995;154:4865-4873.
13. Nonoguchi H, Uchida S, Shiigai T, Endou H: Effect of chronic metabolic acidosis on ammonia production from L-glutamine in microdissected rat nephron segments. Pflugers Arch 1985;403:229-235.
14. Ueno Y, Ishii M, Takahashi S, Igarashi T, Toyota T, LaRusso NF: Different susceptibility of mice to immune-mediated cholangitis induced by immunization with carbonic anhydrase II. Lab Invest 1998;78:629-637.
15. Sebastian A, Hulter HN, Kurtz I, Maher T, Schambelan M: Disorders of distal nephron function. Am J Med 1982;72:289-307.
16. Sebastian A, Morris RC Jr: Renal tubular acidosis. Clin Nephrol 1977;7:216-230.
17. Wrong O, Davies HE: The excretion of acid in renal disease. Q J Med 1959;28:259-313.