Impaired spatial and non-spatial configural learning in patients with hippocampal pathology

Neuropsychologia

Volumn 45, Issue 12, 2007, Pages 2699-2711

  Kumaran, Dharshan ^a   Hassabis, Demis ^a   Spiers, Hugo J ^a   Vann, Seralynne D ^b   Vargha Khadem, Faraneh ^c   Maguire, Eleanor A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Amnesia; Associative; Configural; Hippocampus; Memory; Non spatial; Reinforcement learning; Spatial

Indexed keywords

ADULT; ARTICLE; BRAIN DAMAGE; CASE REPORT; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; HYPOTHESIS; INTROSPECTION; KNOWLEDGE; LEARNING; LEARNING DISORDER; MALE; NONLINEAR SYSTEM; OUTCOME ASSESSMENT; PATHOLOGY; REINFORCEMENT; TASK PERFORMANCE; TEMPORAL LOBE;

ADULT; ALGORITHMS; AMNESIA; BRAIN DISEASES; FEMALE; HIPPOCAMPUS; HUMANS; HYPOXIA-ISCHEMIA, BRAIN; LEARNING; LIMBIC ENCEPHALITIS; MAGNETIC RESONANCE IMAGING; MALE; MENINGOENCEPHALITIS; MENTAL RECALL; MIDDLE AGED; NEOSTRIATUM; NEUROPSYCHOLOGICAL TESTS; PHOTIC STIMULATION; PSYCHOMOTOR PERFORMANCE; RECURRENCE; SPACE PERCEPTION; TEMPORAL LOBE; TREATMENT OUTCOME; VISUAL FIELDS;

EID: 34547411490     PISSN: 00283932     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropsychologia.2007.04.007     Document Type: Article

References (43)

1. Aggleton J.P., and Pearce J.M. Neural systems underlying episodic memory: Insights from animal research. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 356 1413 (2001) 1467-1482
2. Aggleton J.P., Vann S.D., Denby C., Dix S., Mayes A.R., Roberts N., et al. Sparing of the familiarity component of recognition memory in a patient with hippocampal pathology. Neuropsychologia 43 12 (2005) 1810-1823
3. Alvarado M.C., and Rudy J.W. Rats with damage to the hippocampal-formation are impaired on the transverse-patterning problem but not on elemental discriminations. Behavioral Neuroscience 109 2 (1995) 204-211
4. Baddeley A., Vargha-Khadem F., and Mishkin M. Preserved recognition in a case of developmental amnesia: Implications for the acquisition of semantic memory?. Journal of Cognitive Neuroscience 13 3 (2001) 357-369
5. Bayley P.J., Frascino J.C., and Squire L.R. Robust habit learning in the absence of awareness and independent of the medial temporal lobe. Nature 436 7050 (2005) 550-553
6. Burgess N., Becker S., King J.A., and O'Keefe J. Memory for events and their spatial context: Models and experiments. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 356 1413 (2001) 1493-1503
7. Burgess N., Maguire E.A., and O'Keefe J. The human hippocampus and spatial and episodic memory. Neuron 35 4 (2002) 625-641
8. Cohen N.J., and Eichenbaum H. Memory, amnesia and the hippocampal system (1993), MIT Press, Cambridge, MA
9. Davidson T.L., McKernan M.G., and Jarrard L.E. Hippocampal lesions do not impair negative patterning: A challenge to configural association theory. Behavioral Neuroscience 107 2 (1993) 227-234
10. Eichenbaum H. Hippocampus: Cognitive processes and neural representations that underlie declarative memory. Neuron 44 1 (2004) 109-120
11. Foerde K., Knowlton B.J., and Poldrack R.A. Modulation of competing memory systems by distraction. Proceedings of the National Academy of Sciences of the United States of America 103 31 (2006) 11778-11783
12. Gadian D.G., Aicardi J., Watkins K.E., Porter D.A., Mishkin M., and Vargha-Khadem F. Developmental amnesia associated with early hypoxic-ischaemic injury. Brain 123 Pt 3 (2000) 499-507
13. Gluck M.A., Shohamy D., and Myers C. How do people solve the "weather prediction" task? Individual variability in strategies for probabilistic category learning. Learning and Memory 9 6 (2002) 408-418
14. Han J.S., Gallagher M., and Holland P. Hippocampal lesions enhance configural learning by reducing proactive interference. Hippocampus 8 2 (1998) 138-146
15. Hassabis D., Kumaran D., Vann S.D., and Maguire E.A. Patients with hippocampal amnesia cannot imagine new experiences. Proceedings of the National Academy of Sciences of the United States of America 104 5 (2007) 1726-1731
16. Hopkins R.O., Myers C.E., Shohamy D., Grossman S., and Gluck M. Impaired probabilistic category learning in hypoxic subjects with hippocampal damage. Neuropsychologia 42 4 (2004) 524-535
17. King J.A., Burgess N., Hartley T., Vargha-Khadem F., and O'Keefe J. Human hippocampus and viewpoint dependence in spatial memory. Hippocampus 12 6 (2002) 811-820
18. King J.A., Trinkler I., Hartley T., Vargha-Khadem F., and Burgess N. The hippocampal role in spatial memory and the familiarity-Recollection distinction: A case study. Neuropsychology 18 3 (2004) 405-417
19. Knowlton B.J., Mangels J.A., and Squire L.R. A neostriatal habit learning system in humans. Science 273 5280 (1996) 1399-1402
20. Maguire E.A., Vargha-Khadem F., and Mishkin M. The effects of bilateral hippocampal damage on fMRI regional activations and interactions during memory retrieval. Brain 124 Pt 6 (2001) 1156-1170
21. McClelland J.L., McNaughton B.L., and O'Reilly R.C. Why there are complementary learning systems in the hippocampus and neocortex: Insights from the successes and failures of connectionist models of learning and memory. Psychological Review 102 3 (1995) 419-457
22. McKenna P., and Gerhand S. Preserved semantic learning in an amnesic patient. Cortex 38 1 (2002) 37-58
23. Meeter M., Myers C.E., Shohamy D., Hopkins R.O., and Gluck M.A. Strategies in probabilistic categorization: Results from a new way of analyzing performance. Learning and Memory 13 2 (2006) 230-239
24. Moses S.N., and Ryan J.D. A comparison and evaluation of the predictions of relational and conjunctive accounts of hippocampal function. Hippocampus 16 1 (2006) 43-65
25. O'Keefe J., and Nadel L. The hippocampus as a cognitive map (1978), Oxford University Press, Oxford
26. O'Reilly R.C., and Norman K.A. Hippocampal and neocortical contributions to memory: Advances in the complementary learning systems framework. Trends in Cognitive Science 6 12 (2002) 505-510
27. O'Reilly R.C., and Rudy J.W. Conjunctive representations in learning and memory: Principles of cortical and hippocampal function. Psychological Review 108 2 (2001) 311-345
28. Poldrack R.A., Clark J., Pare-Blagoet E.J., Shohamy D., Creso Moyano J., and Gluck M.A. Interactive memory systems in the human. Brain. Nature 414 6863 (2001) 546-550
29. Poldrack R.A., and Packard M.G. Competition among multiple memory systems: Converging evidence from animal and human brain studies. Neuropsychologia 41 3 (2003) 245-251
30. Reed J.M., and Squire L.R. Impaired transverse patterning in human amnesia is a special case of impaired memory for two-choice discrimination tasks. Behavioral Neuroscience 113 1 (1999) 3-9
31. Rickard T.C., and Grafman J. Losing their configural mind. Amnesic patients fail on transverse patterning. Journal of Cognitive Neuroscience 10 4 (1998) 509-524
32. Rudy J.W., and Sutherland R.J. The hippocampal formation is necessary for rats to learn and remember configural discriminations. Behavioural Brain Research 34 1-2 (1989) 97-109
33. Rudy J.W., and Sutherland R.J. Configural association theory and the hippocampal formation: An appraisal and reconfiguration. Hippocampus 5 5 (1995) 375-389
34. Samarasekera S.R., Vincent A., Welch J.L., Jackson M., Nichols P., and Griffiths T.D. Course and outcome of acute limbic encephalitis with negative voltage-gated potassium channel antibodies. Journal of Neurology Neurosurgery and Neuropsychiatry 78 4 (2007) 391-394
35. Sanderson D., Pearce J.M., Kyd R., and Aggleton J.P. The importance of the rat hippocampus for learning the structure of visual arrays. European Journal of Neuroscience 24 (2006) 1781-1788
36. Scoville W.B., and Milner B. Loss of recent memory after bilateral hippocampal lesions. Journal of Neurology, Neurosurgery and Psychiatry 20 1 (1957) 11-21
37. Smith C., and Squire L.R. Declarative memory, awareness, and transitive inference. Journal of Neuroscience 25 44 (2005) 10138-10146
38. Squire L.R., Stark C.E., and Clark R.E. The medial temporal lobe. Annual Review of Neuroscience 27 (2004) 279-306
39. Sutherland R.J., McDonald R.J., Hill C.R., and Rudy J.W. Damage to the hippocampal formation in rats selectively impairs the ability to learn cue relationships. Behavioral and Neural Biology 52 3 (1989) 331-356
40. Vargha-Khadem F., Gadian D.G., Watkins K.E., Connelly A., Van Paesschen W., and Mishkin M. Differential effects of early hippocampal pathology on episodic and semantic memory. Science 277 5324 (1997) 376-380
41. Vincent A., Buckley C., Schott J.M., Baker I., Dewar B.K., Detert N., et al. Potassium channel antibody-associated encephalopathy: A potentially immunotherapy-responsive form of limbic encephalitis. Brain 127 Pt 3 (2004) 701-712
42. Wechsler D. Wechsler Test of Adult Reading (2001), Psychological Corporation, London
43. Yin H.H., and Knowlton B.J. The role of the basal ganglia in habit formation. Nature Reviews: Neuroscience 7 6 (2006) 464-476