Efficacy of pre- and postoperative oral dextromethorphan for reduction of intra- and 24-hour postoperative morphine consumption for transabdominal hysterectomy

Pain Medicine

Volumn 8, Issue 5, 2007, Pages 462-467

  Chau In, Waraporn ^a   Sukmuan, Busabong ^a   Ngamsangsirisapt, Kriengsak ^a   Jirarareungsak, Winita ^a  

^a KHON KAEN UNIVERSITY   (Thailand)

Author keywords

Dextromethorphan; Morphine; NMDA receptor antagonist; Opioid consumption; Pain; Postoperative

Indexed keywords

DEXTROMETHORPHAN; DIAZEPAM; MORPHINE; PLACEBO;

ABDOMINAL HYSTERECTOMY; ADULT; ANALGESIA; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSAGE FORM COMPARISON; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; DRUG USE; FEMALE; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; PAIN ASSESSMENT; PATIENT CONTROLLED ANALGESIA; PEROPERATIVE CARE; POSTOPERATIVE ANALGESIA; POSTOPERATIVE CARE; POSTOPERATIVE PAIN; PREOPERATIVE CARE; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SEDATION; SIDE EFFECT; UNSPECIFIED SIDE EFFECT; UTERUS DISEASE; VISUAL ANALOG SCALE;

ABDOMINAL PAIN; ADMINISTRATION, ORAL; ADULT; ANALGESICS, OPIOID; DEXTROMETHORPHAN; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; HYSTERECTOMY; MIDDLE AGED; MORPHINE; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PLACEBOS; POSTOPERATIVE CARE; PREOPERATIVE CARE; TIME FACTORS; TREATMENT OUTCOME;

EID: 34547400407     PISSN: 15262375     EISSN: 15264637     Source Type: Journal    
DOI: 10.1111/j.1526-4637.2006.00226.x     Document Type: Article

References (25)

1. Kawamata T, Omote K, Kawamata M, Namiki A. Premedication with oral dextromethorphan reduces post-operative pain after tonsillectomy. Anesth Analg 1998; 86: 594-7.
2. Woolf CJ, Thompson SW. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation: Implications for the treatment of post-injury pain hypersensitivity states. Pain 1991; 44: 203-9.
3. Grace RF, Power I, Umedaly H, et al. Preoperative dextromethorphan reduces intraoperative but not post-operative morphine requirements after laparotomy. Anesth Analg 1998; 87: 1135-8.
4. Choi DM, Kliffer AP, Douglas MJ. Dextromethorphan and intrathecal morphine for analgesia after caesarean section under spinal anaesthesia. Br J Anaesth 2003; 90: 653-8.
5. Steinberg GK, Bell TE, Yenari MA. Dose escalation safety and tolerance study of the N-methyl-D aspartate antagonist dextromethorphan in neurosurgery patients. J Neurosurg 1996; 84: 860-6.
6. McConaghy PM, McSorley P, McCaughey W, Campbell WI. Dextromethorphan and pain after total abdominal hysterectomy. Br J Anaesth 1998; 81: 731-6.
7. Gottschalk A, Schroeder F, Ufer M, et al. Amantadine, N-Methyl-D-Aspartate receptor antagonist, does not enhance post-operative analgesia in women undergoing abdominal hysterectomy. Anesth Analg 2001; 93: 192-6.
8. Wilder-Smith CH, Knopfli R, Wilder-Smith OHG. Perioperative magnesium infusion and post-operative pain. Acta Anaesthesiol Scand 1997; 41: 1023-7.
9. Fu ES, Miguel R, Scharf JE. Preemptive ketamine decreases post-operative narcotic requirements in patients undergoing abdominal surgery. Anesth Analg 1997; 84: 1086-90.
10. Weinbroum AA, Rudick V, Parer G, Ben-Abraham R. The role of dextromethorphan in pain control. Can J Anaesth 2000; 47: 585-96.
11. Raffa RB. A novel approach to the pharmacology of analgesics. Am J Med 1996; 101: 40-6.
12. McQuay HJ, Caroll D, Jadad AR, et al. Dextromethorphan for the treatment of neuropathic pain: A double-blind randomized controlled crossover trial with integral n-of-1 design. Pain 1994; 59: 127-33.
13. Heiskanen T, Hartel B, Dahl ML, Seppala T, Kalso E. Analgesic effects of dextromethorphan and morphine in patients with chronic pain. Pain 2002; 96: 261-7.
14. Wu CT, Yu JC, Yeh CC, et al. Preincisional dextromethorphan treatment decreases post-operative pain and opioid requirement after laparoscopic cholecystectomy. Anesth Analg 1999; 88: 1331-4.
15. Chia YY, Liu K, Chow LH, Lee TY. The preoperative administration of intravenous dextromethorphan reduces post-operative morphine consumption. Anesth Analg 1999; 89: 748-52.
16. Rose JB, Cuy R, Cohen DE, Schreiner MS. Preoperative oral dextromethorphan does not reduce pain or analgesic consumption in children after adenotonsillectomy. Anesth Analg 1999; 88: 749-53.
17. Wadhwa A, Clarke D, Goodchild CS, Young D. Large-dose oral dextromethorphan as an adjunct to patient-controlled analgesia with morphine after knee surgery. Anesth Analg 2001; 92: 448-54.
18. Henderson DJ, Withington BS, Wilson JA, Morrison LMM. Perioperative dextromethorphan reduces post-operative pain after hysterectomy. Anesth Analg 1999; 89: 399-402.
19. Price DD, Mao J, Frenk H, Mayer DJ. The N-methyl-D-aspartate receptor antagonist dextromethorphan selectively reduces temporal summation of second pain in man. Pain 1994; 59: 165-74.
20. Kaupilla T, Gronroos M, Pertovarra A. An attempt to attenuate experimental pain in humans by dextromethorphan, an NMDA receptor antagonist. Pharmacol Biochem Behav 1995; 52: 641-4.
21. Robinovitz E, Tsigos C, Max MB. High-dose oral dextromethorphan versus placebo in painful diabetic neuropathy and postherpetic neuralgia. Neurology 1997; 48: 1212-8.
22. Ilkjaer S, Bach LF, Nielsen PA, Wernberg M, Dahl JB. Effect of preoperative oral dextromethorphan on immediate and late post-operative pain and hyperalgesia after total abdominal hysterectomy. Pain 2000; 86: 19-24.
23. Ilkjaer S, Nielsen PA, Bach LF, Wernberg M, Dahl JB. The effect of dextromethorphan, alone or in combination with ibuprofen, on post-operative pain after minor gynaecologecal surgery. Acta Anaesthesiol Scand 2000; 44: 873-7.
24. Wong CS, Wu CT, Yu JC, et al. Preincisional dextromethorphan decreases post-operative pain and opioid requirement after modified radical mastectomy. Can J Anaesth 1999; 46: 1122-6.
25. Weinbroum AA. Dextromethorphan reduces immediate and late post-operative analgesic requirements and improve patients' subjective scorings after epidural lidocaine and general anesthesia. Anesth Analg 2002; 94: 1547-52.