Repeated oral treatment with polysaccharide sulfate reduces insulin resistance and dyslipidemia in diabetic dyslipidemic rat model

Yaoxue Xuebao

Volumn 42, Issue 5, 2007, Pages 488-491

  Zhao, Mei Mi ^a   Li, Zhi ^a   Teng, Zan ^a   Zhao, Jin Sheng ^a   Yu, Xiu Hua ^a   Watanabe, Yasuo ^b   Zhao, Li Mei ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b Nihon Pharmaceutical Univenity ^*  (Japan)

Author keywords

Dyslipidemia; Experimental diabetes mellitus; Polysaccharide sulfate; Streptozotocin

Indexed keywords

ANTILIPEMIC AGENT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; POLYSACCHARIDE; STREPTOZOCIN; SULFATE; TRIACYLGLYCEROL;

ANIMAL; ARTICLE; BLOOD; CHEMICALLY INDUCED DISORDER; DYSLIPIDEMIA; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; INSULIN RESISTANCE; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; RANDOMIZATION; RAT; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTILIPEMIC AGENTS; BLOOD GLUCOSE; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIABETES MELLITUS, EXPERIMENTAL; DYSLIPIDEMIAS; INSULIN; INSULIN RESISTANCE; MALE; POLYSACCHARIDES; RANDOM ALLOCATION; RATS; RATS, WISTAR; STREPTOZOCIN; SULFATES; TRIGLYCERIDES;

EID: 34547326619     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Yang BF. Pharmacology [M]. Beijing: People's Medical Publish House, 2003: 281-290.
2. Wang L, Huang X, Ding Z, et al. The effect of Salvia miltiorrhiza and polysaccharide sulphate on the adhesion of erythrocytes of the patients with cerebral thrombosis to cultured endothelial cells [J]. J West China Univ Med Sci, 1995, 26: 381-385.
3. Guo XH, Zhao SP. In vitro studies on the antithromobosis of polysaccharide sulfate compound [J]. J Chin Clin Med, 2001, 2: 36-37.
4. Zhang C, Jiang LQ, Sun YA, et al. Regulating effects by different dosage of polysaccharide sulfate in ischemic heart and cerebral disease patients with hyperlipidemia [J]. Chin J Clin Pharm, 2001, 10: 210-213.
5. Read MJ, Meszaros K, Entes LJ, et al. A new rat model of type 2 diabetes : the fat-fed, streptozotocin-treated rat [J]. Metabolism, 2000, 49: 1390-1394.
6. Leng SH, Lu FE, Xu LJ. Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion [J]. Acta Pharmacol Sin, 2004, 25: 496-502.
7. Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease [J]. Diabetes, 1988, 37: 1595-1607.
8. Bergman RN. Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approach [J]. Diabetes, 1989, 38: 1512-1527.
9. Kraegen EW, Clark PW, Jenkins AB, et al. Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats [J]. Diabetes, 1991, 40: 1397-1403.
10. Ding SY, Shen ZF, Chen YT, et al. Pioglitazone can ameliorate insulin resistance in low-dose streptozotocin and high sucrose-fat diet induced obese rats [J]. Acta Pharmacol Sin, 2005, 26: 575-580.
11. Zhang FL, Ye CZ, Li G, et al. The rat model of type 2 diabetic mellitus and its glycometabolism characters [J]. Exp Anim, 2003, 52: 401-407.
12. Stumvoll M, Goldstein BJ, Van Haeften TW. Type 2 diabetes ; principles of pathogenesis and therapy [J]. Lancet, 2005, 365: 1333-1346.
13. Taskinen MR. Hyperlipidemia in diabetes [J]. Baillieres Clin Endocrinol Metab, 1990, 4: 743-775.
14. Betteridge DJ. Diabetic dyslipidemias [J]. Acta Diabetol, 1999, 36: S25-29.
15. Durrington PN. Diabetic dyslipidemia [J]. Baillieres Best Pract Res Clin Endocrinol Metab, 1999, 13: 265-278.
16. Zhang C, Jiang LQ, Liu KX, et al. Effect of polysaccharide sulfate on insulin resistance in treatment of type 2 diabetes mellitus and hyperlipidemia [J]. Chin J Clin Pharm, 2003, 12: 24-26.
17. Li GW, Pan XR, Lillioja S, et al. A new index of insulin sensitivity applicable to people [J]. Chin J Intern Med, 1993, 32: 656-660.