Adenovirus-mediated gene transfer of interleukin-4 into pancreatic stellate cells promotes interleukin-10 expression

Journal of Cellular and Molecular Medicine

Volumn 10, Issue 4, 2006, Pages 884-895

  Brock, Peter ^a   Sparmann, Gisela ^a   Ritter, Thomas ^b   Jaster, Robert ^a   Liebe, Stefan ^a   Emmrich, Jörg ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

Adenoviral gene transfer; Interleukin 10; Interleukin 4; Pancreatic stellate cells

Indexed keywords

ADENOVIRIDAE; HUMAN ADENOVIRUS TYPE 5; RATTUS;

INTERLEUKIN 10; INTERLEUKIN 4; RECOMBINANT PROTEIN; STAT6 PROTEIN; STAT6 PROTEIN, HUMAN;

ADENOVIRUS; ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; GENE EXPRESSION REGULATION; GENE TRANSFER; GENETICS; LEWIS RAT; MALE; METABOLISM; PANCREAS; RAT;

ADENOVIRIDAE; ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; INTERLEUKIN-10; INTERLEUKIN-4; MALE; PANCREAS; RATS; RATS, INBRED LEW; RECOMBINANT PROTEINS; STAT6 TRANSCRIPTION FACTOR;

EID: 34547249965     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2006.tb00532.x     Document Type: Article

References (36)

1. Binkley CE, Zhang L, Greenson JK, Giordano TJ, Kuick R, Misek D, Hanash S, Logsdon CD, Simeone DM. The molecular basis of pancreatic fibrosis: common stromal gene expression in chronic pancreatitis and pancreatic adenocarcinoma. Pancreas 2004; 29: 254-63.
2. Kloppel G, Maillet B. Pathology of acute and chronic pancreatitis. Pancreas 1993; 8: 659-70.
3. Apte MV, Haber PS, Darby SJ, Rodgers SC, McCaughan GW, Korsten MA, Pirola RC, Wilson JS. Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut 1999; 44: 534-41.
4. Jaster R. Molecular regulation of pancreatic stellate cell function. Mol Cancer 2004; 3: 26.
5. Kruse ML, Hildebrand PB, Timke C, Folsch UR, Schmidt WE. TGFbeta1 autocrine growth control in isolated pancreatic fibroblastoid cells/stellate cells in vitro. Regul Pept. 2000; 90: 47-52.
6. Apte MV, Haber PS, Applegate TL, Norton ID, McCaughan GW, Korsten MA, Pirola RC, Wilson JS. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut 1998; 43: 128-33.
7. Sparmann G, Hohenadl C, Tornoe J, Jaster R, Fitzner B, Koczan D, Thiesen HJ, Glass A, Winder D, Liebe S, Emmrich J. Generation and characterization of immortalized rat pancreatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2004; 287: G211-9.
8. Prieto J, Herraiz M, Sangro B, Qian C, Mazzolini G, Melero I, Ruiz J. The promise of gene therapy in gastrointestinal and liver diseases. Gut 2003; 52: ii49-54.
9. Russell WC. Update on adenovirus and its vectors. J Gen Virol. 2000; 81: 2573-604.
10. Ebert MP, Ademmer K, Muller-Ostermeyer F, Friess H, Buchler MW, Schubert W, Malfertheiner P. CD8+CD103+ T cells analogous to intestinal intraepithelial lymphocytes infiltrate the pancreas in chronic pancreatitis. Am J Gastroenterol. 1998; 93: 2141-7.
11. Emmrich J, Weber I, Nausch M, Sparmann G, Koch K, Seyfarth M, Lohr M, Liebe S. Immunohistochemical characterization of the pancreatic cellular infiltrate in normal pancreas, chronic pancreatitis and pancreatic carcinoma. Digestion 1998; 59: 192-8.
12. Hunger RE, Mueller C, Z'graggen K, Friess H, Buchler MW. Cytotoxic cells are activated in cellular infiltrates of alcoholic chronic pancreatitis. Gastroenterology 1997; 112: 1656-63.
13. Sparmann G, Behrend S, Merkord J, Kleine HD, Graser E, Ritter T, Liebe S, Emmrich J. Cytokine mRNA levels and lymphocyte infiltration in pancreatic tissue during experimental chronic pancreatitis induced by dibutyltin dichloride. Dig Dis Sci. 2001; 46: 1647-56.
14. Constant SL, Bottomly K. Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu Rev Immunol. 1997; 15: 297-322.
15. Cameron MJ, Arreaza GA, Waldhauser L, Gauldie J, Delovitch TL. Immunotherapy of spontaneous type 1 diabetes in nonobese diabetic mice by systemic interleukin-4 treatment employing adenovirus vector-mediated gene transfer. Gene Ther. 2000; 7: 1840-6.
16. Prud'homme GJ. Gene therapy of autoimmune diseases with vectors encoding regulatory cytokines or inflammatory cytokine inhibitors. J Gene Med. 2000; 2: 222-32.
17. Van de Loo FA, van den Berg WB Gene therapy for rheumatoid arthritis. Lessons from animal models, including studies on interleukin-4, interleukin-10, and interleukin-1 receptor antagonist as potential disease modulators. Rheum Dis Clin North Am. 2002; 28: 127-49.
18. Kolls J, Peppel K, Silva M, Beutler B. Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer. Proc Natl Acad Sci USA. 1994; 91: 215-9.
19. Ritter T, Vogt K, Rieck P, Schilling-Schon A, Kolls J, Hartmann C, Volk HD, Pleyer U. Adenovirus-mediated gene transfer of interleukin-4 to corneal endothelial cells and organ cultured corneas leads to high IL-4 expression. Exp Eye Res. 1999; 69: 563-8.
20. Sparmann G, Glass A, Brock P, Jaster R, Koczan D, Thiesen HJ, Liebe S, Emmrich J. Inhibition of lymphocyte apoptosis by pancreatic stellate cells: impact of interleukin-15. Am J Physiol Gastrointest Liver Physiol. 2005; 289: G842-51.
21. Brock P, Sparmann G, Ritter T, Jaster R, Liebe S, Emmrich J. Interleukin-4 gene transfer into rat pancreas by recombinant adenovirus. Scand J Gastroenterol 2005; 40: 1109-17.
22. Jaster R, Lichte P, Fitzner B, Brock P, Glass A, Karopka T, Gierl L, Koczan D, Thiesen HJ, Sparmann G, Emmrich J, Liebe S. Peroxisome proliferator-activated receptor gamma overexpression inhibits pro-fibrogenic activities of immortalised rat pancreatic stellate cells. J Cell Mol Med. 2005; 9: 670-82.
23. Chomarat P, Banchereau J. An update on interleukin-4 and its receptor. Eur Cytokine Netw. 1997; 8: 333-44.
24. Kay MA, Glorioso JC, Naldini L. Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics. Nat Med. 2001; 7: 33-40.
25. Verma IM, Somia N. Gene therapy - promises, problems and prospects. Nature 1997; 389: 239-42.
26. Fontana L, Nuzzo M, Urbanelli L, Monaci P. General strategy for broadening adenovirus tropism. J Virol. 2003; 77: 11094-104.
27. Hidaka C, Milano E, Leopold PL, Bergelson JM, Hackett NR, Finberg RW, Wickham TJ, Kovesdi I, Roelvink P, Crystal RG. CAR-dependent and CAR-independent pathways of adenovirus vector-mediated gene transfer and expression in human fibroblasts. J Clin Invest 1999; 103: 579-87.
28. Wersto RP, Rosenthal ER, Crystal RG, Spring KR. Uptake of fluorescent dyes associated with the functional expression of the cystic fibrosis transmembrane conductance regulator in epithelial cells. Proc Natl Acad Sci USA. 1996; 93: 1167-72.
29. Kim SH, Lechman ER, Bianco N, Menon R, Keravala A, Nash J, Mi Z, Watkins SC, Gambotto A, Robbins PD. Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis. J Immunol. 2005; 174: 6440-8.
30. de Vries JE. Immunosuppressive and anti-inflammatory properties of interleukin 10. Ann Med. 1995; 27: 537-41.
31. Ding L, Shevach EM. IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function. J Immunol. 1992; 148: 3133-9.
32. Morita Y, Yamamura M, Kawashima M, Aita T, Harada S, Okamoto H, Inoue H, Makino H. Differential in vitro effects of IL-4, IL-10, and IL-13 on proinflamma-tory cytokine production and fibroblast proliferation in rheumatoid synovium. Rheumatol Int. 2001; 20: 49-54.
33. Furukawa H, Oshima K, Tung T, Cui G, Laks H, Sen L. Liposome-mediated combinatorial cytokine gene therapy induces localized synergistic immunosuppression and promotes long-term survival of cardiac allografts. J Immunol. 2005; 174: 6983-92.
34. Rogy MA, Beinhauer BG, Reinisch W, Huang L, Pokieser P. Transfer of interleukin-4 and interleukin-10 in patients with severe inflammatory bowel disease of the rectum. Hum Gene Ther. 2000; 11: 1731-41.
35. Kuroda K, Shinkai H. Downregulation of decorin expression in dermal fibroblasts by interleukin-4. Arch Dermatol Res. 1997; 289: 476-80.
36. Paul WE. Interleukin 4: signalling mechanisms and control of T cell differentiation. Ciba Found Symp. 1997; 204: 208-16.