How genetics and biology helped humanity to survive falciparum malaria

Parassitologia

Volumn 48, Issue 4, 2006, Pages 553-559

  Arese, P ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

G6PD deficiency; Haldane's malaria hypothesis; Malaria resistance; Ring stage phagocytosis; Sickle cell anemia

Indexed keywords

COMPLEMENT COMPONENT C3; PROTOZOON ANTIBODY; REACTIVE OXYGEN METABOLITE;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; COMORBIDITY; ERYTHROCYTE DISORDER; ERYTHROCYTE MEMBRANE; FEMALE; GENETIC SELECTION; GENETICS; GENOTYPE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY; GROWTH, DEVELOPMENT AND AGING; HOST PARASITE INTERACTION; HUMAN; IMMUNOLOGY; MALARIA FALCIPARUM; MALE; METABOLISM; MORTALITY; PARASITOLOGY; PHAGOCYTOSIS; PHYSIOLOGY; PLASMODIUM FALCIPARUM; SICKLE CELL TRAIT;

ANIMALS; ANTIBODIES, PROTOZOAN; COMORBIDITY; COMPLEMENT C3; ERYTHROCYTE MEMBRANE; ERYTHROCYTES, ABNORMAL; FEMALE; GENOTYPE; GLUCOSEPHOSPHATE DEHYDROGENASE DEFICIENCY; HOST-PARASITE RELATIONS; HUMANS; MALARIA, FALCIPARUM; MALE; MODELS, BIOLOGICAL; PHAGOCYTOSIS; PLASMODIUM FALCIPARUM; REACTIVE OXYGEN SPECIES; SELECTION (GENETICS); SICKLE CELL TRAIT;

EID: 34547249945     PISSN: 00482951     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Arese P, Turrini F, Schwarzer E (2006). Band 3/complement-mediated recognition and removal of normally senescent and pathological human erythrocytes. Cell Physiol Biochem 2005;16: 133-146.
2. Akide-Ndunge O, Ayi K, Arese P (2003). The Haldane malaria hypothesis: facts, artifacts, and a prophecy. Redox Rep 8: 311-317.
3. Allison AC (1954). Protection afforded by sickle-cell trait against subtertian malaria infection. Br Med J i: 290-294.
4. Allison AC (1964), Polymorphism and natural selection in human populations, Cold Spring Harbor Symp Quant Biol 29: 137-149.
5. Allison AC, Clyde DF (1961). Malaria in African children with deficient glucose-6-phosphate dehydrogenase. Br Med J i: 1346-1348.
6. Ayi K, Turrini F, Piga A, Arese P (2004). Enhanced phagocytosis of ring-parasitized mutant erythrocytes: a common mechanism that may explain protection against falciparum malaria in sickle trait and beta-thalassemia trait. Blood 104: 3364-3371.
7. Bookchin RM, Lew VL (2002). Sickle red cell dehydration: mechanisms and interventions. Curr Opin Hematol 9: 107-110.
8. Cappadoro M, Giribaldi G, O'Brien E et al (1998). Early phagocytosis of glucose-6-phosphate dehydrogenase (G6PD)-deficient erythrocytes parasitized by Plasmodium falciparum may explain malaria protection in G6PD deficiency. Blood 92: 2527-2534.
9. Cappellini MD, Tavazzi D, Duca L, et al (1999). Metabolic indicators of oxidative stress correlate with haemichrome attachment to membrane, band 3 aggregation and eythrophagocytosis in beta-thalassaemia intermedia. Br J Haematol 104: 504-512.
10. Flint J, Harding RM, Clegg JB, Boyce AJ (1993). Why are some genetic diseases common? Distinguishing selection from other processes by molecular analysis of globin gene variants. Hum Genet 91: 91-117.
11. Giribaldi G, Ulliers D, Mannu F et al (2001). Growth of Plasmodium falciparum induces stage-dependent haemichrome formation, oxidative aggregation of band 3, membrane deposition of complement and antibodies, and phagocytosis of parasitized erythrocytes. Br J Haematol 113: 492-499.
12. Greene L (1993). G6PD deficiency as protection against falciparum malaria: An epidemiologic critique of population and experimental studies. Year Phys Anthropol 36: 153-178.
13. Haldane JBS (1949a). Disease and evolution. Ric Sci 19 (Suppl): 68-76.
14. Haldane JBS (1949b). The rate of mutation of human genes. Hereditas 35 (Suppl): 267-273.
15. Hebbel RP (1990), The sickle erythrocyte in double jeopardy: autoxidation and iron decompartmentalization. Semin Hematol 27: 51-69.
16. Hill AVS (2001). The genomics and genetics of human infectious disease susceptibility. Ann Rev Genomics Hum Genet 2: 373-300.
17. Kannan R, Labotka R, Low PS (1988). Isolation and characterization of the hemichrome-stabilized membrane protein aggregates from sickle erythrocytes. J Biol Chem 263: 13766-13773.
18. Lell B, May J, Schmidt-Ott RJ et al (1999). The role of red blood cell polymorphisms in resistance and susceptibility to malaria. Clin Infect Dis 28: 794-799.
19. Livingstone FB (1971). Malaria and human polymorphisms. Ann Rev Genet 5: 33-64.
20. Low PS, Waugh SM, Zinke K, Drenckhahn D (1985). The role of hemoglobin denaturation and band 3 clustering in red blood cell aging. Science 227: 531-533.
21. Lutz HU. Erythrocyte clearance. In: Blood Cells. Subcellular Biochemistry, Vol 17, Erythroid Cells, edited by JR Harris. Plenum Press, New York, 1990, pp 81-120.
22. Luzzatto L, Usanga EA, Reddy S (1969). Glucose-6-phosphate dehydrogenase deficient red cells: Resistance to infection by malarial parasites. Science 164: 839-842.
23. Luzzatto L, Nwachuku-Jarrett ES, Reddy S (1970). Increased sickling of parasitized erythrocytes as mechanism of resistance against malaria in the sickle-cell trait. Lancet J: 319322.
24. Luzzatto L, Sodeinde O, Martini G (1983). Genetic variation in the host and adaptive phenomena in Plasmodium falciparum infection. Ciba Foundation Symp 94: 159-173.
25. Mackey JP, Vivarelli F (1954). Sickle-cell anaemia (letter). Br Med J i: 276.
26. Mannu F, Arese P, Cappellini MD et al(1995). Role of hemichrome binding to erythrocyte membrane in the generation of band 3 alterations in beta thalassemia intermedia erythrocytes. Blood 86: 2014-2020.
27. Mohanty D, Mukherjee MB (2002). Sickle cell disease in India. Curr Opin Hematol 9: 117-122.
28. Mohanty D, Sukumar S, Mukherjee MB, Colah RB (2003). G6PD deficiency and malaria in India. Am J Hematol 72: 150-151.
29. Pasvol G, Weatherall DJ, Wilson RJM (1978). Cellular mechanism for the protective effect of haemoglobin S against P falciparum malaria. Nature 274: 701-703.
30. Roberts DJ, Harris T, Williams T, The influence of inherited traits on malaria infection. In: Susceptibility to Infectious Diseases: the Importance of Host Genetics, edited by R. Bellamy. Cambridge University Press, Cambridge, UK, 2004, pp 139-184.
31. Roth EFJr, Raventos-Suarez C, Rinaldi A, Nagel RL (1983). Glucose-6-phosphate dehydrogenase deficiency inhibits in vitro growth of Plasmodium falciparum, Proc Natl Acad Sci USA 80: 298-299.
32. Ruwende C, Khoo SC, Snow RW et al (1995). Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria. Nature 376: 246-249.
33. Siniscalco M, Bernini L, Latte B, Motulsky AG (1961). Favism and thalassemia in Sardinia and their relationship to malaria. Nature 190: 1175-1180.
34. Spielman A, D'Antonio M. Mosquito. A Natural History of Our Most Persistent and Deadly Foe. Faber and Faber, London, 2001.
35. Tishkoff SA, Varkonyi R, Cahinhinan N et al (2001). Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer malarial resistance. Science 293: 455-462.
36. Turrini F, Ginsburg H, Bussolino F et al (1992). Phagocytosis of Plasmodium falciparum-infected human red blood cells by human monocytes: Involvement of immune and nonimmune determinants and dependence on parasite developmental stage. Blood 80: 801-808.
37. Turrini F, Arese P, Yuan J, Low PS (1991). Clustering of integral membrane proteins of the human erythrocyte membrane stimulates autologous IgG binding, complement deposition, and phagocytosis. J Biol Chem 266: 23611-23617.
38. Williams TN (2006). Human red blood cell polymorphism and malaria. Curr Opin Microbiol 9: 1-7.