Comparison of the effects of cetylpyridinium chloride with an essential oil mouth rinse on dental plaque and gingivitis - a six-month randomized controlled clinical trial

Journal of Clinical Periodontology

Volumn 34, Issue 8, 2007, Pages 658-667

  Albert Kiszely, A ^a   Pjetursson, B E ^a   Salvi, G E ^a   Witt, J ^b   Hamilton, A ^b   Persson, G R ^a   Lang, N P ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

Cetylpyridinium chloride (CPC); Dental plaque; Essential oils; Gingivitis; Mouth rinse; Prevention

Indexed keywords

CETYLPYRIDINIUM SALT; ESSENTIAL OIL; TOPICAL ANTIINFECTIVE AGENT;

ADOLESCENT; ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EPIDEMIOLOGY; FEMALE; GINGIVITIS; HUMAN; MALE; MICROBIOLOGY; MIDDLE AGED; MOUTH HYGIENE; RANDOMIZED CONTROLLED TRIAL; TOOTH PLAQUE;

ADOLESCENT; ADULT; ANTI-INFECTIVE AGENTS, LOCAL; CETYLPYRIDINIUM; DENTAL PLAQUE; EPIDEMIOLOGIC METHODS; FEMALE; GINGIVITIS; HUMANS; MALE; MIDDLE AGED; MOUTHWASHES; OILS, VOLATILE;

EID: 34547222417     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2007.01103.x     Document Type: Article

References (56)

1. Al-Yahfoufi, Z., Mombelli, A., Wicki, A. Lang, N. P. (1995) The effect of plaque control in subjects with shallow pockets and high prevalence of periodontal pathogens. Journal of Periodontology 22, 78 84.
2. Ånerud, Å., Löe, H., Boysen, H. Smith, M. (1979) The natural history of periodontal disease in man. Changes in gingival health and oral hygiene before 40 years of age. Journal of Periodontal Research 14, 526 540.
3. Attin, T., Hornecker, E., Loesche, W. J. Syed, S. A. (2005) Tooth brushing and oral health: how frequently and when should tooth brushing be performed? Oral Health and Preventive Dentistry 3, 135 140.
4. Axelsson, P. Lindhe, J. (1981) The significance of maintenance care in the treatment of periodontal disease. Journal of Clinical Periodontology 8, 281 294.
5. Axelsson, P., Lindhe, J. Nyström, B. (1991) On the prevention of caries and periodontal disease. Results of a 15-year longitudinal study in adults. Journal of Clinical Periodontology 18, 182 189.
6. Axelsson, P., Lindhe, J. Nyström, B. (2004) The long-term effect of a plaque control program on tooth mortality, caries and periodontal disease in adults. Results after 30 years of maintenance. Journal of Clinical Periodontology 31, 749 757.
7. Baelum, V., Fejerskov, O. Karring, T. (1986) Oral hygiene, gingivitis and periodontal breakdown in adult Tanzanians. Journal of Periodontal Research 21, 221 232.
8. Baelum, V., Wen-Min, L., Fejerskov, O. Xia, C. (1988) Tooth mortality and periodontal condition in 60- to 80-year-old Chinese. Scandinavian Journal of Dental Research 96, 99 107.
9. Bollen, C. M., Vandekerckhoven, B. N., Papaioannou, W., Van Eldere, J. Quirynen, M. (1996) Full- versus partial-mouth disinfection in the treatment of periodontal infections. A pilot study: long-term microbiological observations. Journal of Clinical Periodontology 23, 960 970.
10. Brecx, M. C., Gautschi, M., Gehr, P. Lang, N. P. (1987) Variability of histologic criteria in clinically healthy human gingival. Journal of Periodontal Research 22, 468 472.
11. Brecx, M. C., Lehmann, B., Siegwart, C. M., Gehr, P. Lang, N. P. (1988) Observations on the initial stages of healing following human experimental gingivitis. Journal of Clinical Periodontology 15, 123 129.
12. Charles, C. H., Mostler, K. M., Bartels, L. L. Mankodi, S. M. (2004) Comparative antiplaque and antigingivitis effectiveness of a chlorhexidine and an essential oil mouthrinse: 6-month clinical trial. Journal of Clinical Periodontology 31, 878 884.
13. Cumming, B. R. Löe, H. (1973) Consistency of plaque distribution in individuals without special home care instruction. Journal of Periodontal Research 8, 94 100.
14. Dahlén, G., Lindhe, J., Sato, K., Hanamura, H. Okamoto, H. (1992) The effect of supragingival plaque control on the subgingival microbiota in subjects with periodontal disease. Journal of Clinical Periodontology 19, 802 809.
15. Fine, D. H. (1988) Mouthrinses as adjuncts for plaque and gingivitis management. American Journal of Dentistry 1, 259 263.
16. Fine, D. H., Furgang, D. Barnett, M. L. (2001) Comparative antimicrobial activities of antiseptic mouthrinses against isogenic planktonic and biofilm forms of Actinobacillus actinomycetemcomitans. Journal of Clinical Periodontology 28, 697 700.
17. Frandsen, A. (1986) Mechanical oral hygiene practices. In : Dental Plaque Control Measures and Oral Hygiene Practices, Löe, H. Kleinman, D. (eds). pp. 93 116. Oxford : IRL Press.
18. Gerber, J., Wenaweser, D., Heitz-Mayfield, L. J., Lang, N. P. Persson, G. R. (2006) Comparison of bacterial plaque samples from titanium implant and tooth surfaces by different methods. Clinical Oral Implants Research 17, 1 7.
19. Goodson, J. M., Palys, M. D., Carpino, E., Regan, E. O., Sweeney, M. Socransky, S. S. (2004) Microbiological changes associated with dental prophylaxis. Journal of the American Dental Association 135, 1559 1564.
20. Grossman, E., Meckel, A. H., Isaacs, R. L., Ferretti, G. A., Sturzenberger, O. P., Bollmer, B. W., Moor, D. J., Lijana, R. C. Manhart, M. D. (1989) A clinical comparison of antibacterial mouthrinses: effects of chlorhexidine, phenolics, and sanguinarine on dental plaque and gingivitis. Journal of Periodontology 60, 435 440.
21. Haffajee, A. D., Socransky, S. S., Dzink, J. L., Taubman, M. A., Ebersole, J. L. Smith, D. J. (1988) Clinical, microbiological and immunological features of subjects with destructive periodontal diseases. Journal of Clinical Periodontology 15, 240 246.
22. Lang, N. P., Cumming, B. R. Löe, H. (1973) Toothbrushing frequency as it relates to plaque development and gingival health. Journal of Periodontology 44, 396 405.
23. Lindhe, J., Axelsson, P. Tollskog, G. (1975) Effect of proper oral hygiene on gingivitis and dental caries in Swedish schoolchildren. Community Dentistry and Oral Epidemiology 3, 150 155.
24. Lindhe, J., Okamoto, H., Yoneyama, T., Haffajee, A. Socransky, S. (1989) Longitudinal changes in periodontal disease in untreated subjects. Journal of Clinical Periodontology 16, 662 670.
25. Listgarten, M. A., Schifer, C. C. Laster, L. (1985) 3-year longitudinal study of the periodontal status of an adult population with gingivitis. Journal of Clinical Periodontology 12, 225 238.
26. Löe, H. Silness, J. (1963) Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontologica Scandinavia 21, 533 551.
27. Löe, H., Theilade, E. Jensen, S. B. (1965) Experimental gingivitis in man. Journal of Periodontology 36, 177 187.
28. Loesche, W. J. Syed, S. A. (1978) Bacteriology of human experimental gingivitis: effect of plaque and gingivitis score. Infection and Immunity 21/3, 830 839.
29. Katsoulis, J., Heitz-Mayfield, L. J., Weibel, M., Hirschi, R., Lang, N. P. Persson, G. R. (2005) Impact of sample storage on detection of periodontal bacteria. Oral Microbiology and lmmunology 20, 128 130.
30. Kornman, K. S. (1986) Antimicrobial agents. In : Dental Plaque Control Measures and Oral Hygiene Practices, Löe, H. Kleinman, D. (eds). pp. 121 142. National Institute of Dental Research, Bethesda, MD.
31. Kubert, D., Rubin, M., Barnett, M. Vincent, J. W. (1993) Antiseptic mouthrinses induced microbial cell surface alterations. American Journal of Dentistry 6, 277 279.
32. MacGregor, I. D. M. Rugg-Gunn, A. J. (1979) Survey of toothbrushing duration in 85 uninstructed English schoolchildren. Community Dentistry and Oral Epidemiology 7, 297 298.
33. Mandel, I. D. (1988) Chemotherapeutic agents for controlling plaque and gingivitis. Journal of Clinical Periodontology 15, 488 498.
34. Mankodi, S., Wachs, G. N., Petrone, D. M., Chaknis, P., Petrone, M., DeVizio, W. Volpe, A. R. (2005) A 6-month clinical trial to study the effects of a cetylpyridinium chloride mouthrinse on gingivitis and plaque. American Journal of Dentistry 18, 9A 14A.
35. Merchant, A., Pitiphat, W., Douglass, C. W., Crohin, C. Joshipura, K. (2002) Oral hygiene practices and periodontitis in health care professionals. Journal of Periodontology 73, 531 535.
36. Moore, W. E., Holdeman, L. V., Smibert, R. M., Hash, D. E., Burmeister, J. A. Ranney, R. R. (1982) Bacteriology of severe periodontitis in young adult humans. Infection and Immunity 38, 1137 1148.
37. Oliver, R. C., Brown, L. J. Löe, H. (1998) Periodontal disease in the United State population. Journal of Periodontology 69, 269 278.
38. Ouhayoun, J.-P. (2003) Penetrating the plaque biofilm: impact of essential oil mouthwash. Journal of Clinical Periodontology 30, 10 12.
39. Page, R. C. Schroeder, H. E. (1976) Pathogenesis of inflammatory periodontal disease. A summary of current work. Laboratory Investigation 34, 235 249.
40. Payne, W. A., Page, R. C., Ogilvie, A. L. Hall, W. B. (1975) Histopathologic features of the initial and early stages of experimental gingivitis in man. Journal of Periodontal Research 10, 51 64.
41. Quirynen, M., Soers, C., Desnyder, M., Dekeyser, C., Pauwels, M. van Steenberghe, D.A (2005) 0.05? cetyl pyridinium chloride/0.05? chlorhexidine mouth rinse during maintenance phase after initial periodontal therapy. Journal of Clinical Periodontology 32, 390 400.
42. Ramseier, C. (2005) Potential impact of subject-based risk factor control on periodontitis. Journal of Clinical Periodontology 32, 278 285.
43. Santos, S., Herrera, D., Lopez, E., O'Connor, A., Gonzalez, I. Sanz, M. (2004) A randomized clinical trial on the short-term clinical and microbiological effects of the adjunctive use of a 0.05? chlorhexidine mouth rinse for patients in supportive periodontal care. Journal of Clinical Periodontology 31, 45 51.
44. Sekino, S. Ramberg, P. (2005) The effect of a mouthrinse containing phenolic compounds on plaque formation and developing gingivitis. Journal of Clinical Periodontology 32, 1083 1088.
45. Sekino, S., Ramberg, P., Uzel, N. G., Socransky, S. Lindhe, J. (2003) Effect of various chlorhexidine regimens on salivary bacteria and de novo plaque formation. Journal of Clinical Periodontology 30, 919 925.
46. Sekino, S., Ramberg, P., Uzel, N. G., Socransky, S. Lindhe, J. (2004) The effect of a chlorhexidine regimen on de novo plaque formation. Journal of Clinical Periodontology 31, 609 614.
47. Siegrist, B. Kornman, K. S. (1982) The effect of supragingival plaque control on the composition of the subgingival microbial flora in ligature-induced periodontitis in the monkey. Journal of Dental Research 61, 936 941.
48. Siegrist, B. E., Brecx, M. C., Gusberti, F. A., Joss, A. Lang, N. P. (1991) In vivo early human dental plaque formation on different supporting substances. A scanning electron microscopic and bacteriological study. Clinical Oral Implants Research 2, 38 46.
49. Silness, J. Löe, H. (1964) Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontologica Scandinavia 22, 121 135.
50. Socransky, S. S., Haffajee, A. D., Smith, C. Dibart, S. (1991) Relation of counts of microbial species to clinical status at the sampled site. Journal of Clinical Periodontology 18, 766 775.
51. Socransky, S. S., Haffajee, A. D., Smith, C., Martin, L., Haffajee, J. A., Uzel, N. G. Goodson, J. M. (2004) Use of checkerboard DNA-DNA hybridization to study complex microbial ecosystems. Oral Microbiology and Immunology 19, 352 362.
52. Southern, E. N., McCombs, G. B., Tolle, S. L. Marinak, K. (2006) The comparative effects of 0.12? chlorhexidine and herbal oral rinse on dental plaque-induced gingivitis. Journal of Dental Hygiene 80, 12.
53. Theilade, E., Wright, W. H., Jensen, S. B. Löe, H. (1966) Experimental gingivitis in man. II. A longitudinal clinical and bacteriological investigation. Journal of Periodontal Research 1, 1 13.
54. Van Strydonck, D. A., Timmermaman, N. F., van der Velden, U. van der Weijden, G. A. (2005) Plaque inhibition of two commercially available chlorhexidine mouthrinses. Journal of Clinical Periodontology 32, 305 309.
55. Wilson, T. G. Jr. (1987) Compliance - a review of the literature with possible application to periodontics. Journal of Perodontology 58, 706 714.
56. Witt, J. J., Walters, P., Bsoul, S., Gibb, R., Dunavent, J. Putt, M. (2005) Comparative clinical trial of two antigingivitis mouthrinses. American Journal of Dentistry 18, 15A 17A.