Acute pulmonary embolism: Risk stratification in the emergency department

Internal and Emergency Medicine

Volumn 2, Issue 2, 2007, Pages 119-129

  Becattini, C ^a   Agnelli, G ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Anticoagulants; Pulmonary embolism; Thrombolysis; Venous thromboembolism

Indexed keywords

TROPONIN;

ARTICLE; CARDIOGENIC SHOCK; COMPUTER ASSISTED TOMOGRAPHY; ECHOENCEPHALOGRAPHY; ELECTROCARDIOGRAPHY; EMERGENCY HEALTH SERVICE; HEART LEFT VENTRICLE FUNCTION; HUMAN; HYPERTENSION; LUNG EMBOLISM; MORTALITY; PROGNOSIS; RISK ASSESSMENT; RISK FACTOR;

ECHOENCEPHALOGRAPHY; ELECTROCARDIOGRAPHY; EMERGENCY SERVICE, HOSPITAL; HUMANS; HYPERTENSION; PROGNOSIS; PULMONARY EMBOLISM; RISK ASSESSMENT; RISK FACTORS; SHOCK, CARDIOGENIC; TOMOGRAPHY, X-RAY COMPUTED; TROPONIN; VENTRICULAR DYSFUNCTION, LEFT;

EID: 34547211125     PISSN: 18280447     EISSN: 19709366     Source Type: Journal    
DOI: 10.1007/s11739-007-0033-y     Document Type: Article

References (67)

1. Dalen JE, Alpert JS (1975) Natural history of pulmonary embolism. Prog Cardiovasc Dis 17:257-270
2. Anderson FA Jr, Wheeler HB, Goldberg RJ (1991) A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. Arch Intern Med 151:933-938
3. Dalen J (2002) Pulmonary embolism: what have we learned since Virchow? Treatment and prevention. Chest 122:1801-1817
4. Siragusa S (2006) D-dimer testing: advantages and limitations in emergency medicine for managing acute venous thromboembolism. Intern Emerg Med 1:59-66
5. Manfredini R (2006) D-dimer for the diagnosis of acute venous thromboembolism in the emergency department: a Janus-face marker. Intern Emerg Med 1:54-58
6. Goldhaber SZ, Visani L, De Rosa M (1999) Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry. Lancet 353:1386-1389
7. Konstantinides S, Geibel A, Olschewski M et al (1997) Association between thrombolytic treatment and the prognosis of hemodynamically stable patients with major pulmonary embolism. Circulation 96:882-886
8. Konstantinindes S, Geibel A, Heusel G et al for the Management Strategies and Prognosis of Pulmonary Embolism-3 Trial Investigators (2002) Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism. N Engl J Med 347:1143-1150
9. The MATISSE Investigators (2003) Subcutaneous Fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism. N Engl J Med 349:1695-1702
10. Simonneau G, Sors H, Charbonnier B et al (1997) A comparison of low molecular weight heparin with unfractionated heparin for acute pulmonary embolism. N Engl J Med 337:663-669
11. Carson JL (1992) The clinical course of pulmonary embolism. N Engl J Med 326:1240-1245
12. Heit J, Silverstein M, Mohr D et al (1999) Predictors of survival after deep vein thrombosis and pulmonary embolism. Arch Intern Med 159:445-453
13. Geibel A, Zehender M, Kasper W et al (2005) Prognostic value of the ECG on admission in patients with acute major pulmonary embolism. Eur Resp J 25:843-848
14. Wan S, Quinlan DJ, Agnelli G, Eikelboom J (2004) Thrombolysis compared with heparin for the initial treatment of pulmonary embolism. Circulation 110:744-749
15. Castelli R, Tarsia P, Tantardini C et al (2003) Syncope in patients with pulmonary embolism: comparison between patients with syncope as the presenting symptom of pulmonary embolism and patients with pulmonary embolism without syncope. Vasc Med 8:257-261
16. Calvo-Romero JM, Perez-Miranda M, Bureo-Dacal P (2004) Syncope in acute pulmonary embolism. Eur J Emerg Med 11:208-209
17. Kline JA, Kubin AK, Patel MM et al (2000) Alveolar dead space as a predictor of severity of pulmonary embolism. Acad Emerg Med 7:611-617
18. Wicki J, Perrier A, Perneger TV et al (2000) Predicting adverse outcome in patients with acute pulmonary embolism: a risk score. Thromb Haemost 84:548-552
19. Aujesky D, Obroskj DS, Stone RA et al (2005) Derivation and validation of a prognostic model for pulmonary embolism. Am J Resp Crit Care Med 172:1041-1046
20. Aujesky D, Obroskj DS, Stone RA et al (2006) A prediction rule to identify low-risk patients with pulmonary embolism. Arch Intern Med 166:169-175
21. Stein PD, Dalen JE, McIntyre KM et al (1975) The electrocardiogram in acute pulmonary embolism. Prog Cardiovasc Dis 17:247-257
22. Ferrari E, Imbert A, Chevalier T et al (1997) The ECG in pulmonary embolism. Chest 111:537-543
23. Iles S, Le Heron CJ, Davies G et al (2004) ECG score predicts those with the greatest percentage of perfusion defects due to acute pulmonary thromboembolic disease. Chest 125:1651-1656
24. Bogdanov DP (2001) Appearance of right bundle branch block in the electrocardiograms of patients with pulmonary embolism as a marker for obstruction of the main pulmonary trunk. J Electrocardiol 34:185-188
25. Geibel A, Zehender M, Kasper W et al (2005) Prognostic value of the ECG on admission in patients with acute major pulmonary embolism. Eur Resp J 25:843-848
26. Kosuge M, Kimura K, Ishikawa T et al (2006) Prognostic significance of inverted T waves in patients with acute pulmonary embolism. Circ J 70:750-755
27. Kucher N, Walpoth N, Wustmann K et al (2003) QR in V1 - an ECG sign associated with right ventricular strain and adverse clinical outcome in pulmonary embolism. Eur Heart J 24:1113-1119
28. Alpert JS (1976) Mortality in patients treated for pulmonary embolism. JAMA 236:1477-1480
29. Howarth DM, Lan L, Thomas PA, Allen LW (1999) 99mTc technegas ventilation and perfusion lung scintigraphy for the diagnosis of pulmonary embolus. J Nucl Med 40:579-584
30. Mastora I, Remy-Jardin M, Masson P et al (2003) Severity of acute pulmonary embolism: evaluation of a new spiral CT angiographic score in correlation with echocardiographic data. Eur Radiol 13:29-35
31. Qanadli SD, Hajjam ME, Vieillard-Baron A et al (2001) New CT index to quantify arterial obstruction in pulmonary embolism. AJR Am J Roentgenol 176:1415-1420
32. Reid JH, Murchison JT (1998) Acute right ventricular dilatation: a new helical CT sign of massive pulmonary embolism. Clin Radiol 53:694-698
33. Collomb D, Paramelle PJ, Calaque O et al (2003) Severity assessment of acute pulmonary embolism: evaluation using 128 helical CT. Eur Radiol 13:1508-1514
34. Ng CS, Wells AU, Padley SP (1999) A CT sign of chronic pulmonary arterial hypertension: the ratio of main pulmonary artery to aortic diameter. J Thorac Imaging 14:270-278
35. Qanadli SD, El Hajjam M, Vieillard-Baron A et al (2001) New CT index to quantify arterial obstruction in pulmonary embolism: comparison with angiographic index and echocardiography. AJR Am J Roentgenol 176:1415-1420
36. van der Meer RW, Pattynama PMT, van Strijen MJL et al (2006) Right-ventricular dysfunction and the pulmonary vascular obstruction index: predictable variables of the clinical course over 3 months in patients with acute lung emboli. Ned Tijdschr Geneeskd 150:845-850
37. Schoepf UJ, Kucher N, Kipfmueller F et al (2004) Right ventricular enlargement on chest computed tomography a predictor of early death in acute pulmonary embolism. Circulation 110:3276-3280
38. Goldhaber SZ (2002) Echocardiography in the management of pulmonary embolism Ann Intern Med 136:691-700
39. McConnell MV, Solomon SD, Rayan ME et al (1996) Regional right ventricular dysfunction detected by echocardiography in acute pulmonary embolism. Am J Cardiol 78:469-473
40. Wolfe MW (1994) Prognostic significance of right ventricular hypokinesis and perfusion lung scan defects in pulmonary embolism. Am Heart J 127:1371-1375
41. Lualdi JC, Goldhaber SZ (1995) Right ventricular dysfunction after acute pulmonary embolism: pathophysiologic factors, detection and therapeutic implications. Am Heart J 130:1276-1282
42. Fisman DN, Malcom ID, Ward ME (1997) Echocardiographic detection of pulmonary embolism in transit: implications for institution of thrombolytic therapy. Can J Cardiol 13:685-687
43. Ribeiro A (1997) Echocardiography doppler in pulmonary embolism: right ventricular dysfunction as a predictor of mortality rate. Am Heart J 134:479-487
44. Kasper W, Konstantinides S, Geibel A et al (1997) Prognostic significance of right ventricular afterload stress detected by echocardiography in patients with clinically suspected pulmonary embolism. Heart 77:346-349
45. Grifoni S, Olivotto I, Cecchini P et al (2000) Short term clinical outcome of patients with pulmonary embolism, normal blood pressure and echocardiographical right ventricular dysfunction. Circulation 101:2817-2822
46. Kucher N, Rossi E, De Rosa M, Goldhaber SZ (2005) Prognostic role of echocardiography among patients with acute pulmonary embolism and a systolic arterial pressure of 90 mm Hg or higher. Arch Intern Med 165:1777-1781
47. Gibson N, Sohne M, Buller H (2006) Prognostic value of echocardiography and spiral computed tomography in patients with pulmonary embolism. Curr Opin Pulm Med 11:380-384
48. Katus HA, Remppis A, Neumann FJ et al (1991) Diagnostic efficiency of troponin T measurements in acute myocardial infarction. Circulation 83:902-912
49. Muller-Bardorff M, Weidtmann B, Giannitsis E et al (2002) Release kinetics of cardiac troponin T in survivors of confirmed severe pulmonary embolism. Clin Chem 48:673
50. Hamm CW, Giannitsis E, Katus HA (2002) Cardiac troponin elevations in patients without acute coronary syndrome. Circulation 106:2871-2872
51. Mehta NJ, Jani K, Khan IA (2003) Clinical usefulness and prognostic value of elevated cardiac Troponin I levels in acute pulmonary embolism. Am Heart J 145:821-825
52. Pruszczyk P, Bochowicz A, Torbicki A et al (2003) Cardiac troponin T monitoring identifies high-risk group of normotensive patients with acute pulmonary embolism. Chest 123:1947-1952
53. Meyer T, Binder L, Hruska N et al (2000) Cardiac troponin I elevation in acute pulmonary embolism is associated with right ventricular dysfunction. J Am Coll Cardiol 36:1632-1636
54. Janata K, Holzer M, Laggner AN, Mullner M (2003) Cardiac troponin T in the severity assessment of patients with pulmonary embolism: cohort study. BMJ 326:312-313
55. Giannitsis E, Muller-Bardorff M, Kurowski V et al (2000) Independent prognostic value of cardiac troponin T in patients with confirmed pulmonary embolism. Circulation 102:211-217
56. Konstantinides S, Geibel A, Olschewski M et al (2002) Importance of cardiac troponins I and T in risk stratification of patients with acute pulmonary embolism. Circulation 106:1263-1268
57. Scridon T, Scridon C, Skali H et al (2005) Prognostic significance of troponin elevation and right ventricular enlargement in acute pulmonary embolism. Am J Cardiol 96:303-305
58. Kucher N, Wallmann D, Carone A et al (2003) Incremental prognostic value of troponin I and echocardiography in patients with acute pulmonary embolism. Eur Heart J 24:1651-1656
59. Morrison K, Harrison A, Krishnaswamy P et al (2002) Utility of a rapid B-Natriuretic peptide assay in differentiating congestive heart failure from lung disease in patients presenting with dyspnea. J Am Coll Cardiol 39:202-209
60. Ten Wolde, Tulevski II, Mulder JWM et al (2003) Brain natriuretic peptide as a predictor of adverse outcome in patients with pulmonary embolism. Circulation 107:2082-2084
61. Kucher N, Printzen G, Doernhoefer T et al (2003) Low probrain natriuretic peptide levels predict benign clinical outcome in acute pulmonary embolism. Circulation 107:1576-1578
62. Pieralli F, Olivotto I, Vanni S et al (2006) Usefulness of bedside testing for brain natriuretic peptide to identify right ventricular dysfunction and outcome in normotensive patients with acute pulmonary embolism. Am J Cardiol 97:1386-1390
63. Kruger S, Graf J, Merx MW et al (2004) Brain natriuretic peptide predicts right heart failure in patients with acute pulmonary embolism. Am Heart J 147:60-65
64. Sohne M, Ten Wolde M, Boomsma F et al (2006) Brain natriuretic peptide in hemodynamically stable acute pulmonary embolism. J Thromb Haemost 4:552-556
65. Kostrubiec M, Pruszczyk P, Bochowicz A et al (2005) Biomarker-based risk assessment model in acute pulmonary embolism. Eur Heart J 26:2166-2172
66. Pruszczyk P, Bochowicz A, Kostrubiec M et al (2003) Myoglobin stratifies short term risk in acute major pulmonary embolism. Clin Chim Acta 338:53-56
67. Kaczynska A, Pelsers M, Bochowicz A et al (2006) Plasma heart-type fatty acid binding protein is superior to troponin and myoglobin for rapid risk stratification in acute pulmonary embolism. Clin Chim Acta 371:117-123