In rheumatoid arthritis, a polymorphism in the HLA-G gene concurs in the clinical response to methotrexate treatment [4]

Annals of the Rheumatic Diseases

Volumn 66, Issue 8, 2007, Pages 1125-1126

  Baricordi, Olavio R ^a   Govoni, Marcello ^a   Rizzo, Roberta ^a   Trotta, Francesco ^a  

^a UNIVERSITY OF FERRARA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HLA G ANTIGEN; METHOTREXATE;

3' UNTRANSLATED REGION; CLINICAL ASSESSMENT; CONTROLLED STUDY; GENOTYPE; HUMAN; HUMAN CELL; LETTER; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; UNSPECIFIED SIDE EFFECT;

ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; GENOTYPE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; METHOTREXATE; POLYMORPHISM, GENETIC; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 34547210744     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.2006.064022     Document Type: Letter

References (10)

1. Kremer JM. Metotrexate pharmacogenomics. Ann Rheum Dis 2006;65:1121-3.
2. Hughes LB, Beasley TM, Patel H, Tiwari HK, Morgan SL, Baggott JE, et al. Racial or ethnic differences in allele frequencies of single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritis. Ann Rheum Dis 2006;65:1213-18.
3. Rizzo R, Rubini M, Govoni M, Padovan M, Melchiorri L, Stignani M, et al. HLA-G 14bp polymorphism regulates the methotrexate response in rheumatoid arthritis. Pharmacogenet Genomics 2006;9:615-23.
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8. Fujii T, Ishitani A, Geraghty DE. A soluble form of the HLA-G antigens is encoded by a messenger ribonucleic acid containing intron 4. J Immunol 1994;153:5516-24.
9. Rizzo R, Mapp CE, Melchiorri L, Maestrelli P, Visentin A, Ferretti S, et al. Detective production of soluble HLA-G molecules by peripheral blood monocytes in patients with asthma. J Allergy Clini Invest 2005;115:508-13.
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