Enantioselective total synthesis of isishippuric acid B via intramolecular michael reaction

Organic Letters

Volumn 9, Issue 13, 2007, Pages 2557-2559

  Torihata, Munefumi ^a   Nakahata, Takashi ^a   Kuwahara, Shigefumi ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DICARBOXYLIC ACID; ISISHIPPURIC ACID B; UNCLASSIFIED DRUG;

ANIMAL; ANTHOZOA; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; SYNTHESIS;

ANIMALS; ANTHOZOA; ANTINEOPLASTIC AGENTS; DICARBOXYLIC ACIDS; MOLECULAR STRUCTURE;

EID: 34547181292     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol070956f     Document Type: Article

References (20)

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16. 2 at -78°C, two silyl enol ethers [9 and its isomer, (R)-6-methyl-1-(triisopropylsilyl)oxy1,3-cycloheptadiene] were obtained in a ratio of 1:1.
17. 2) was also unsuccessful.
18. Structure 15 is drawn as a conformer preferred for the Michael cyclization in the next step, and does not mean the real conformation of 15.
19. 2-Bu moiety and a geminal methyl group in the transition state leading from the (Z)-isomer to 16.
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