A double-blind, randomized, placebo-controlled trial of the effect of testosterone cream on the sexual motivation of menopausal hysterectomized women with hypoactive sexual desire disorder

Climacteric

Volumn 10, Issue 4, 2007, Pages 335-343

  El Hage, G ^a   Eden, J A ^a,b   Manga, R Zoa ^a  

^a ROYAL HOSPITAL FOR WOMEN   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Randomized trial; Sexual desire; Testosterone; Women

Indexed keywords

ANDRO FEME; ESTROGEN; TESTOSTERONE; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ADULT; ANALYTIC METHOD; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; HYSTERECTOMY; MENOPAUSE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SCORING SYSTEM; SEXUAL BEHAVIOR; SEXUAL DYSFUNCTION; TERTIARY HEALTH CARE;

ADMINISTRATION, TOPICAL; ANDROGENS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ESTRADIOL; FEMALE; HUMANS; HYSTERECTOMY; LIBIDO; MENOPAUSE; MIDDLE AGED; SEXUAL DYSFUNCTION, PHYSIOLOGICAL; TESTOSTERONE;

EID: 34547146099     PISSN: 13697137     EISSN: 14730804     Source Type: Journal    
DOI: 10.1080/13697130701364644     Document Type: Article

References (26)

1. Chakravarti S, Collins WP, Newton JR, Oram DH, Studd JWW. Endocrine changes and symptomatology after oophorectomy in premenopausal women. Br J Obstet Gynaecol 1977;84:769-75
2. Burger HG, Hailes J, Menelaus M, Nelson J, Hudson B, Balazs N. The management of persistent menopausal symptoms with oestrogen and testosterone implants: clinical, lipid and hormonal results. Maturitas 1984;6:351-8
3. Sherwin BB, Gelfand MM, Brender W. Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause. Psychosom Med 1985;47:339-51
4. Sherwin BB, Gelfand MM. The role of androgen in the maintenance of sexual functioning in oophorectomized women. Psychosom Med 1987;49:397-409
5. Sherwin BB. Affective changes with estrogen and androgen replacement therapy in surgically menopausal women. J Affect Disorders 1988;14:177-87
6. Sherwin BB. Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women. Psychoneuroendocrinology 1988;13:345-57
7. Shifren JL, Braunstein GD, Simon JA, et al. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 2000;343:682-8
8. Kaplan HS, Owett T. The female androgen deficiency syndrome. J Sex Marital Therapy 1993;19:3-24
9. Davis SR, McCloud P, Straus BJ, Burger H. Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas 1995;21:227-36
10. Raisz LG, Wiita B, Artis A, et al. Comparison of the effects of estrogen alone and estrogen plus androgen on biochemical markers of bone formation and resorption in postmenopausal women. J Clin Endocrinol. Metab 1996;81:37-43
11. Floter A, Nathorst-Boos J, Carlstrom K, von Schoultz B. Addition of testosterone to estrogen replacement therapy in oophorectomized women: effects on sexuality and well-being. Climacteric 2002;5:357-65
12. Watts NB, Notelovitz M, Timmons MC, Addison B. Comparison of oral estrogens and estrogens plus androgen on bone mineral density, menopausal symptoms, and lipid-lipoprotein profiles in surgical menopause. Obstet Gynecol 1995;85:529-36
13. Davidson JM. Sexual behaviour and its relationship to ovarian hormones in the menopause. Maturitas 1985;7:193-201
14. Braunstein GD, Sundwall DA, Katz M, et al. Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women. Arch Intern Med 2005;165:1582-9
15. Buster JE, Kingsberg SA, Aguirre O, et al. Testosterone patch for low sexual desire in surgically menopausal women: a randomized trial. Obstet Gynecol 2005;105:944-52
16. Simon J, Braunstein G, Nachtigall L, et al. Testosterone patch increases sexual activity and desire in surgically menopausal women with hypoactive sexual desire disorder. J Clin Endocrinol Metab 2005;90:5226-33
17. Taylor JF, Rosen RC, Leiblum SR. Self-report assessment of female sexual function: psychometric evaluation of the Brief Index of Sexual Functioning for Women. Arch Sex Behav 1994;23:627-43
18. McNair DM, Lorr M, Droppleman LF. The Edits Manual for the Profile of Mood States. San Diego, California: Edits/Educational and industrial testing service, 1992
19. Lovibond SH, Lovibond PF. Manual for the Depression, Anxiety Stress Scales, 2nd edn. Sydney: Psychological Foundation, 1995
20. Ferriman D, Gallwey J. Clinical assessment of body hair growth in women. J Clin Endocrin 1961;21:1440-7
21. Rosenberg MJ, King TD, Timmons MC. Estrogen-androgen for hormone replacement. A review. J Reprod Med 1997;42:394-404
22. Dow MG, Hart DM, Forrest CA. Hormonal treatments of sexual unresponsiveness in postmenopausal women: a comparative study. Br J Obstet Gynaecol 1983;90:361-6
23. Eden JA. A novel testosterone cream. Presented at the International Menopause Society Meeting, Berlin 2002
24. Urman B, Pride SM, Yuen BH. Elevated serum testosterone, hirsutism and virilism associated with combined androgen-estrogen hormone replacement therapy. Obstet Gynecol 1991;77:595-8
25. Tamimi RM, Hankinson SE, Chen WY, Rosner B, Colditz GA. Combined estrogen and testosterone use and risk of breast cancer in postmenopausal women. Arch Intern Med 2006;166:1483-9
26. Dimitrakakis C, Jones RA, Liu A, Bondy CA. Breast cancer incidence in postmenopausal women using testosterone therapy in addition to usual hormone therapy. Menopause 2004;11:531-5