A pharmacodynamic study on clenbuterol-induced toxicity: β1- and β2-adrenoceptors involvement in guinea-pig tachycardia in an in vitro model

Food and Chemical Toxicology

Volumn 45, Issue 9, 2007, Pages 1694-1699

  Mazzanti, Gabriela ^a   Di Sotto, Antonella ^a   Daniele, Claudia ^a   Battinelli, Lucia ^a   Brambilla, Gianfranco ^b   Fiori, Maurizio ^b   Loizzo, Stefano ^b   Loizzo, Alberto ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Atenolol; Clenbuterol; Growth promoters; Heart rate; ICI 118,551

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CLENBUTEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG INTOXICATION; HYPERTENSION; IN VITRO STUDY; MALE; NONHUMAN; TACHYCARDIA;

ADRENERGIC BETA-AGONISTS; ANIMALS; ATRIAL FUNCTION; CLENBUTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; FOOD CONTAMINATION; GUINEA PIGS; HEART ATRIA; HEART RATE; HUMANS; MALE; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; TACHYCARDIA;

BOS; CAVIA;

EID: 34547138144     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.03.002     Document Type: Article

References (27)

1. Arunlakshana O., and Schild H.O. Some quantitative uses of drug antagonists. Br. J. Pharmacol. 14 (1959) 48-58
2. Barbosa J., Cruz C., Martins J., Silva J.M., Neves C., Alves C., Ramos F., and Da Silveira M.I. Food poisoning by clenbuterol in Portugal. Food Addit. Contam. 22 (2005) 563-566
3. Blass A., Dave M., Fallon R.J., Illera J.C., Illera M., and Sauer M.J. Determination of therapeutic and growth promoting use of clenbuterol by plasma analysis. J. Vet. Pharmacol. Therap. 22 (1999) 234-237
4. Brambilla G., Loizzo A., Fontana L., Strozzi M., Guarino A., and Soprano V. Food poisoning following consumption of clenbuterol-treated veal in Italy. J. Am. Med. Assoc. 278 (1997) 635
5. 2-adrenoceptors in man. Clin. Pharmacol. Ther. 33 (1983) 424-428
6. Bulpitt C.J., and Fletcher A.E. Quality of life evaluation of hypertensive drugs. Pharmacoeconomics 1 (1992) 95-102
7. Culmsee C., Junker V., Kremers W., Thal S., Plesnila M., and Krieglstein J. Combination therapy in ischemic stroke: synergistic neuroprotective effects of memantine and clenbuterol. Stroke 35 (2004) 1197-1202
8. George I., Xydas S., Mancini D.M., Lamanca J., Di Tullio M., Marboe C.C., Shane E., Schulman A.R., Colley P.M., Petrilli C.M., Naka Y., Oz M.C., and Maybaum S. Effect of clenbuterol on cardiac and skeletal muscle function during left ventricular assist device support. J. Heart Lung Transpl. 25 9 (2006) 1084-1090
9. Golf S., and Hansson V. Effects of beta blocking agents on the density of beta adrenoceptors and adenylate cyclase response in human myocardium: intrinsic sympathomimetic activity favours receptor upregulation. Cardio. Res. 20 (1986) 637-644
10. 2-adrenoceptor-mediated in steers. J. Anim. Sci. 73 (1995) 1754-1765
11. Hoffman R.J., Hoffman R.S., Freyberg C.L., Poppenga R.H., and Nelson L.S. Clenbuterol ingestion causing prolonged tachycardia, hypokalemia, and hypophosphatemia with confirmation by quantitative levels. J. Toxicol. - Clin. Toxic. 39 (2001) 339-344
12. Kaumann A.J., and Molenaar P. Modulation of human function through 4 β-adrenoceptor populations. Naunyn-Schmiedebergs Archiv für Pharmakologie 355 (1997) 667-681
13. Maistro S., Chiesa E., Angeletti R., and Brambilla G. Beta blockers to prevent clenbuterol poisoning. The Lancet 346 (1995) 180
14. Mazzanti G., Daniele C., Boatto G., Manca G., Brambilla G., and Loizzo A. New beta-adrenergic agonists used illicitly as growth promoters in animal breeding: chemical and pharmacodynamic studies. Toxicology 187 (2003) 91-99
15. O'Donnell S.R., and Wanstall J.C. Potency and selectivity in vitro of compounds related to isoprenaline and orciprenaline on β-adrenoceptors in the guinea-pig. Brit. J. Pharmacol. 52 (1974) 407-417
16. Palac D.M., Cornish R.D., WcDonald W.J., Middaugh D.A., Howieson D., and Bagby S.P. Atenolol or propranolol therapy does not impair cognitive function or contribute significantly to psychiatric side effects. J. Gen. Intern. Med. 5 (1990) 310-318
17. Prichard B.N., Graham B.R., and Cruickshank J.M. New approaches to the uses of beta blocking drugs in hypertension. J. Hum. Hypertens. 14 (2000) S63-S68
18. Russell F.D., Molenaar P., Edyvane N., Smolich J.J., and Summer R.J. Autoradiographic localization and quantitation of -adrenoceptor subtypes in the guinea-pig sinoatrial node. Mol. Neuropharmacol. 1 (1991) 141-147
19. Spadari M., Coja C., Rodor F., Monnier B., Affaton M.F., Arditti J., Hayek-Lanthois M., David J.M., and Valli M. Doping in sports. Cases reported to the Poison Control Center of Marseille from 1992-2000. La Presse Médicale 30 (2001) 1733-1739
20. Sporano V., Grasso L., Esposito M., Oliviero G., Brambilla G., and Loizzo A. Clenbuterol residues in non-liver containing meat as a cause of collective food poisoning. Vet. Human Toxicol. 40 (1998) 141-143
21. 2-adrenoceptors. J. Smooth Muscle Res. 41 (2005) 153-161
22. Teng Y.D., Choi H., Huang W., Onario R.C., Frontera W.R., Snyder E.Y., and Sabharwal S. Therapeutic effects of clenbuterol in a murine model of amyotrophic lateral sclerosis. Neurosci. Lett. 397 (2006) 155-158
23. AHAW Panel. 2005. Aspects of the biology and welfare of animals used for experimental and other scientific purposes. The EFSA Journal, 292, 1-46.
24. Voss H.P., Shukrula S., Wu T.S., Donnell D., and Bast A. A functional beta-2 adrenoceptor-mediated chronotropic response in isolated guinea-pig heart tissue: selectivity of the potent beta-2 adrenoceptor agonist TA 2005. JPET 271 1 (1994) 386-389
25. Wilson C., and Lincoln C. β-adrenoceptor subtypes in human, rat, guinea-pig and rabbit atria. J. Cardiovas. Pharmacol. 6 (1984) 1216-1221
26. Yamamoto I., Iwata K., and Nakashima M. Pharmacokinetics of plasma and urine clenbuterol in man, rat, and rabbit. J. Pharmacobiodyn. 8 (1985) 385-391
27. Yamanishi T., Chapple C.R., Yasuda K., Yoshida K., and Chess-Williams R. The functional role of β-adrenoceptor subtypes in mediating relaxation of pig urethral smooth muscle. J. Urol. 170 (2003) 2508-2511