Key role of amino acid residues in the dimerization and catalytic activation of the autolysin LytA, an important virulence factor in Streptococcus pneumoniae

Journal of Biological Chemistry

Volumn 282, Issue 24, 2007, Pages 17729-17737

  Romero, Patricia ^a   López, Rubens ^a   García, Ernesto ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID RESIDUES; BIOCHEMICAL CONSEQUENCES; TEICHOIC ACIDS; TRANSLATION PRODUCT;

AMINO ACIDS; CATALYST ACTIVITY; DIMERIZATION; PROTEINS;

BACTERIA;

AMINO ACID; AUTOLYSIN; AUTOLYSIN LYTA; DIMER; MONOMER; N ACETYLMURAMOYLALANINE AMIDASE; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL VIRULENCE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME STRUCTURE; MOLECULAR SIZE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLARIZATION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BASE SEQUENCE; CHOLINE; DIMERIZATION; ENZYME ACTIVATION; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; N-ACETYLMURAMOYL-L-ALANINE AMIDASE; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; STREPTOCOCCUS PNEUMONIAE;

BACTERIA (MICROORGANISMS); SOLENOIDEA; STREPTOCOCCUS PNEUMONIAE;

EID: 34547118354     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M611795200     Document Type: Article

References (54)

1. Levine, O. S., O'Brien, K. L., Knoll, M., Adegbola, R. A., Black, S., Cherian, T., Dagan, R., Goldblatt, D., Grange, A., and Greenwood, B. (2006) Lancet 367, 1880-1882
2. Hoskins, J., Alborn, W. E., Arnold, J., Blaszczak, L. C., Burgett, S., DeHoff, B. S., Estrem, S. T., Fritz, L., Fu, D.-J., Fuller, W., Geringer, C., Gilmour, R., Glass, J. S., Khoje, H., Kraft, A. R., Lagace, R. E., LeBlanc, D. J., Lee, L. N., Lefkowitz, E. J., Lu, J., Matsushima, P., McAhren, S. M., McHenney, M., McLeaster, K., Mundy, C. W., Nicas, T. I., Norris, F. H., O'gara, M., Peery, R. B., Robertson, G. T., Rockey, P., Sun, P.-M., Winkler, M. E., Yang, Y., Young-Bellido, M., Zhao, G., Zook, C. A., Baltz, R. H., Jaskunas, R., Rosteck, P. R. J., Skatrud, P. L., and Glass, J. I. (2001) J. Bacteriol. 183, 5709-5717
3. Lanie, J. A., Ng, W.-L., Kazmierczak, K. M., Andrzejewski, T. M., Davidsen, T. M., Wayne, K. J., Tettelin, H., Glass, J. I., and Winkler, M. E. (2006) J. Bacteriol., 189, 38-51
4. Tettelin, H., Nelson, K. E., Paulsen, I. T., Eisen, J. A., Read, T. D., Peterson, S., Heidelber, J., DeBoy, R. T., Haft, D. H., Dodson, R. J., Durkin, A. S., Gwinn, M., Kolonay, J. F., Nelson, W. C., Peterson, J. D., Umayam, L. A., White, O., Salzberg, S. L., Lewis, M. R., Radune, D., Holtzapple, E., Khouri, H., Wolf, A. M., Utterback, T. R., Hansen, C. L., McDonald, L. A., Feldblyum, T. V., Angiuoli, S., Dickinson, T., Hickey, E. K., Holt, I. E., Loftus, B. J., Yang, F., Smith, H. O., Venter, J. C., Dougherty, B. A., Morrison, D. A., Hollingshead, S. K., and Fraser, C. M. (2001) Science 293, 498-506
5. Rane, L., and Subbarow, Y. (1940) J. Bacteriol. 40, 695-704
6. Tomasz, A. (1967) Science 157, 694-697
7. Giudicelli, S., and Tomasz, A. (1984) J. Bacteriol. 158, 1188-1190
8. Fischer, W. (2000) Res. Microbiol. 151, 421-427
9. López, R., and García, E. (2004) FEMS Microbiol. Rev. 28, 553-580
10. López, R., García, E., García, P., and García, J. L. (2004) in The Pneumococcus (Tuomanen, E. I., Mitchell, T. J., Morrison, D. A., and Spratt, B. G., eds) ASM Press, Washington, D.C.
11. Swiatlo, E., McDaniel, L. S., and Briles, D. E. (2004) in The Pneumococcus (Tuomanen, E. I., Mitchell, T. J., Morrison, D. A., and Spratt, B. G., eds) ASM Press, Washington, D.C.
12. Berry, A. M., and Paton, J. C. (2000) Infect. Immun. 68, 133-140
13. García, E., García, J. L., Ronda, C., García, P., and López, R. (1985) Mol. Gen. Genet. 201, 225-230
14. Tomasz, A., and Westphal, M. (1971) Proc. Natl. Acad. Sci. U. S. A. 68, 2627-2630
15. Höltje, J. V., and Tomasz, A. (1976) J. Biol. Chem. 251, 4199-4207
16. Fernández-Tornero, C., Ramón, A., Fernández-Cabrera, C., Giménez-Gallego, G., and Romero, A. (2002) Acta Crystallogr. Sect. D Biol. Crystallogr. 58, 556-558
17. Varea, J., Saiz, J., López-Zumel, C., Monterroso, B., Medrano, F. J., Arrondo, J. L., Iloro, I., Laynez, J., García, J. L., and Menéndez, M. (2000) J. Biol. Chem. 275, 26842-26855
18. García, E., García, J. L., García, P., Arrarás, A., Sánchez-Puelles, J. M., and López, R. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 914-918
19. Usobiaga, P., Medrano, F. J., Gasset, M., Garcia, J. L., Saiz, J. L., Rivas, G., Laynez, J., and Menendez, M. (1996) J. Biol. Chem. 271, 6832-6838
20. Fernández-Tornero, C., López, R., García, E., Giménez-Gallego, G., and Romero, A. (2001) Nat. Struct. Biol. 8, 1020-1024
21. Fernández-Tornero, C., García, E., López, R., Giménez-Gallego, G., and Romero, A. (2002) J. Mol. Biol. 321, 163-173
22. Sánchez-Puelles, J. M., Sanz, J. M., García, J. L., and García, E. (1990) Gene 89, 69-75
23. Maestro, B., and Sanz, J. M. (2005) Biochem. J. 387, 479-488
24. Díaz, E., López, R., and García, J. L. (1992) J. Bacteriol. 174, 5516-5525
25. Obregón, V., García, P., García, E., Fenoll, A., López, R., and García, J. L. (2002) J. Clin. Microbiol. 40, 2545-2554
26. Sáiz, J. L., López-Zumel, C., Monterroso, B., Varea, J., Arrondo, J. L. R., Iloro, I., García, J. L., Laynez, J., and Menéndez, M. (2002) Protein Sci. 11, 1788-1799
27. Romero, P., López, R., and García, E. (2004) J. Bacteriol. 186, 8229-8239
28. Ottolenghi, E., and Hotchkiss, R. D. (1962) J. Exp. Med. 116, 491-519
29. Sánchez-Puelles, J. M., Ronda, C., García, J. L., García, P., López, R., and García, E. (1986) Eur. J. Biochem. 158, 289-293
30. García, J. L., García, E., and López, R. (1987) Arch. Microbiol. 149, 52-56
31. Ronda, C., García, J. L., García, E., Sánchez- Puelles, J. M., and López, R. (1987) Eur. J. Biochem. 164, 621-624
32. Inouye, S., and Inouye, M. (1985) Nucleic Acids Res. 13, 3101-3110
33. Sambrook, J., and Russell, D. W. (2001) Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
34. Lacks, S., and Hotchkiss, R. D. (1960) Biochim. Biophys. Acta 39, 508-517
35. García, E., Ronda, C., García, J. L., and López, R. (1985) FEMS Microbiol. Lett. 29, 77-81
36. Sánchez-Puelles, J. M., Sanz, J. M., García, J. L., and García, E. (1992) Eur. J. Biochem. 203, 153-159
37. Laemmli, U. K. (1970) Nature 227, 680-685
38. Mosser, J. L., and Tomasz, A. (1970) J. Biol. Chem. 245, 287-298
39. Jones, T. A. (1978) J. Appl. Crystallogr. 11, 268-272
40. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D Biol. Crystallogr. 54, 905-921
41. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950
42. Merritt, E. A., and Murphy, M. E. P. (1994) Acta Crystallogr. Sect. D Biol. Crystallogr. 50, 869-873
43. Lund, E., and Henrichsen, J. (1978) Methods Microbiol. 12, 241-262
44. Llull, D., López, R., and García, E. (2006) J. Clin. Microbiol. 44, 1250-1256
45. Briese, T., and Hakenbeck, R. (1985) Eur. J. Biochem. 146, 417-427
46. Hermoso, J. A., Monterroso, B., Albert, A., Galán, B., Ahrazem, O., García, P., Martínez-Ripoll, M., García, J. L., and Menéndez, M. (2003) Structure (Camb.) 11, 1239-1249
47. Hermoso, J. A., Lagartera, L., González, A., Stelter, M., García, P., Martínez-Ripoll, M., García, J. L., and Menéndez, M. (2005) Nat. Struct. Mol. Biol. 12, 533-538
48. Demarest, S. J., Salbato, J., Elia, M., Zhong, J., Morrow, T., Holland, T., Kline, K., Woodnutt, G., Kimmel, B. E., and Hansen, G. (2005) J. Mol. Biol. 346, 1197-1206
49. Ho, J. G. S., Greco, A., Rupnik, M., and Ng, K. K.-S. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 18373-18378
50. Garcia, J. L., Diaz, E., Romero, A., and Garcia, P. (1994) J. Bacteriol. 176, 4066-4072
51. Sánchez-Puelles, J. M., García, J. L., López, R., and García, E. (1987) Gene 61, 13-19
52. Sheehan, M. M., García, J. L., López, R., and García, P. (1997) Mol. Microbiol. 25, 717-725
53. Varea, J., Monterroso, B., Sáiz, J. L., López-Zumel, C., García, J. L., Laynez, J., García, P., and Menéndez, M. (2004) J. Biol. Chem. 279, 43697-43707
54. Buey, R. M., Monterroso, B., Menéndez, M., Diakun, G., Chacón, P., Hermoso, J. A., and Díaz, J. F. (2007) J. Mol. Biol. 365, 411-424