Colorectal carcinoma rearranges cell surface protein topology and density in CD4+ T cells

Biochemical and Biophysical Research Communications

Volumn 361, Issue 1, 2007, Pages 202-207

  Bene, László ^a   Kanyári, Zsolt ^a   Bodnár, Andrea ^a,b   Kappelmayer, János ^c   Waldmann, Thomas A ^d   Vámosi, György ^a,b   Damjanovich, László ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c UNIVERSITY OF DEBRECEN   (Hungary)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

CD4+ T cells; Colorectal carcinoma; Confocal microscopy; Draining lymph node; Flow cytometry; FRET; ICAM 1; IL 15R; IL 2R; Membrane protein association; MHC I; MHC II; Receptor clustering

Indexed keywords

CELL SURFACE PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 15 RECEPTOR; INTERLEUKIN 2 RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ARTICLE; CANCER PATIENT; CD4+ T LYMPHOCYTE; COLORECTAL CANCER; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

CARCINOMA; CD4-POSITIVE T-LYMPHOCYTES; COLORECTAL NEOPLASMS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HISTOCOMPATIBILITY ANTIGENS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MEMBRANE PROTEINS; MICROSCOPY, CONFOCAL; RECEPTORS, INTERLEUKIN;

EID: 34547115960     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.07.013     Document Type: Article

References (24)

1. Bene L., Balazs M., Matko J., Most J., Dierich M.P., Szollosi J., and Damjanovich S. Lateral organization of the ICAM-1 molecule at the surface of human lymphoblasts: a possible model for its co-distribution with the IL-2 receptor, class I and class II HLA molecules. Eur. J. Immunol. 24 (1994) 2115-2123
2. Damjanovich S., Vereb G., Schaper A., Jenei A., Matko J., Starink J.P., Fox G.Q., Arndt-Jovin D.J., and Jovin T.M. Structural hierarchy in the clustering of HLA class I molecules in the plasma membrane of human lymphoblastoid cells. Proc. Natl. Acad. Sci. USA 92 (1995) 1122-1126
3. Matko J., Bushkin Y., Wei T., and Edidin M. Clustering of class I HLA molecules on the surfaces of activated and transformed human cells. J. Immunol. 152 (1994) 3353-3360
4. Jenei A., Varga S., Bene L., Matyus L., Bodnar A., Bacso Z., Pieri C., Gaspar Jr. R., Farkas T., and Damjanovich S. HLA class I and II antigens are partially co-clustered in the plasma membrane of human lymphoblastoid cells. Proc. Natl. Acad. Sci. USA 94 (1997) 7269-7274
5. Szöllösi J., Horejsi V., Bene L., Angelisova P., and Damjanovich S. Supramolecular complexes of MHC Class I, MHC Class II, CD20, and Tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY. J. Immunol. 157 (1996) 2939-2946
6. Bene L., Bodnar A., Damjanovich S., Vamosi G., Bacso Z., Aradi J., Berta A., and Damjanovich J. Membrane topography of HLA I, HLA II, and ICAM-1 is affected by IFN-gamma in lipid rafts of uveal melanomas. Biochem. Biophys. Res. Commun. 322 (2004) 678-683
7. Bacso Z., Bene L., Damjanovich L., and Damjanovich S. INF-gamma rearranges membrane topography of MHC-I and ICAM-1 in colon carcinoma cells. Biochem. Biophys. Res. Commun. 290 (2002) 635-640
8. Nagy P., Vamosi G., Damjanovich S., and Damjanovich L. ICAM-1 inhibits the homocluster formation of MHC-I in colon carcinoma cells. Biochem. Biophys. Res. Commun. 347 (2006) 758-763
9. Lebedeva T., Dustin M.L., and Sykulev Y. ICAM-1 co-stimulates target cells to facilitate antigen presentation. Curr. Opin. Immunol. 17 (2005) 251-258
10. Anderson H.A., Hiltbold E.M., and Roche P.A. Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation. Nat. Immunol. 1 (2000) 156-162
11. Bodnar A., Bacso Z., Jenei A., Jovin T.M., Edidin M., Damjanovich S., and Matko J. Class I HLA oligomerization at the surface of B cells is controlled by exogenous beta(2)-microglobulin: implications in activation of cytotoxic T lymphocytes. Int. Immunol. 15 (2003) 331-339
12. Gombos I., Detre C., Vamosi G., and Matko J. Rafting MHC-II domains in the APC (presynaptic) plasma membrane and the thresholds for T-cell activation and immunological synapse formation. Immunol. Lett. 92 (2004) 117-124
13. Lebedeva T., Anikeeva N., Kalams S.A., Walker B.D., Gaidarov I., Keen J.H., and Sykulev Y. Major histocompatibility complex class I-intercellular adhesion molecule-1 association on the surface of target cells: implications for antigen presentation to cytotoxic T lymphocytes. Immunology 113 (2004) 460-471
14. Harel-Bellan A., Krief P., Rimsky L., Farrar W.L., and Mishal Z. Flow cytometry resonance energy transfer suggests an association between low-affinity interleukin 2 binding sites and HLA class I molecules. Biochem. J. 268 (1990) 35-40
15. Szollosi J., Damjanovich S., Goldman C.K., Fulwyler M.J., Aszalos A.A., Goldstein G., Rao P., Talle M.A., and Waldmann T.A. Flow cytometric resonance energy transfer measurements support the association of a 95-kDa peptide termed T27 with the 55-kDa Tac peptide. Proc. Natl. Acad. Sci. USA 84 (1987) 7246-7250
16. Vereb G., Matko J., Vamosi G., Ibrahim S.M., Magyar E., Varga S., Szollosi J., Jenei A., Gaspar Jr. R., Waldmann T.A., and Damjanovich S. Cholesterol-dependent clustering of IL-2Ralpha and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts. Proc. Natl. Acad. Sci. USA 97 (2000) 6013-6018
17. Matko J., Bodnar A., Vereb G., Bene L., Vamosi G., Szentesi G., Szollosi J., Gaspar R., Horejsi V., Waldmann T.A., and Damjanovich S. GPI-microdomains (membrane rafts) and signaling of the multi-chain interleukin-2 receptor in human lymphoma/leukemia T cell lines. Eur. J. Biochem. 269 (2002) 1199-1208
18. Vamosi G., Bodnar A., Vereb G., Jenei A., Goldman C.K., Langowski J., Toth K., Matyus L., Szollosi J., Waldmann T.A., and Damjanovich S. IL-2 and IL-15 receptor alpha-subunits are coexpressed in a supramolecular receptor cluster in lipid rafts of T cells. Proc. Natl. Acad. Sci. USA 101 (2004) 11082-11087
19. Damjanovich S., Gáspár Jr. R., and Pieri C. Dynamic receptor superstructures at the plasma membrane. Q. Rev. Biophys. 30 (1997) 67-106
20. Sebestyen Z., Nagy P., Horvath G., Vamosi G., Debets R., Gratama J.W., Alexander D.R., and Szollosi J. Long wavelength fluorophores and cell-by-cell correction for autofluorescence significantly improves the accuracy of flow cytometric energy transfer measurements on a dual-laser benchtop flow cytometer. Cytometry 48 (2002) 124-135
21. Harder T., Scheiffele P., Verkade P., and Simons K. Lipid domain structure of the plasma membrane revealed by patching of membrane components. J. Cell Biol. 141 (1998) 929-942
22. Ramalingam T.S., Chakrabarti A., and Edidin M. Interaction of class I human leukocyte antigen (HLA-I) molecules with insulin receptors and its effect on the insulin-signaling cascade. Mol. Biol. Cell 8 (1997) 2463-2474
23. Betts G.J., Clarke S.L., Richards H.E., Godkin A.J., and Gallimore A.M. Regulating the immune response to tumours. Adv. Drug Deliv. Rev. 58 (2006) 948-961
24. Ichihara F., Kono K., Takahashi A., Kawaida H., Sugai H., and Fujii H. Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers. Clin. Cancer Res. 9 (2003) 4404-4408