Vaginal microbicides for preventing mother-to-child transmission of HIV infection - No evidence of an effect or evidence of no effect?

South African Medical Journal

Volumn 97, Issue 7, 2007, Pages 530-533

  Wiysonge, Charles Shey ^a   Shey, Muki Shehu ^b   Shang, Judith ^c   Kongnyuy, Eugene J ^d   Brocklehurst, Peter ^e  

^a SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c UNIVERSITY OF YAOUNDÉ I   (Cameroon)

^d LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS USED INTRAVAGINALLY; ANTIRETROVIRUS AGENT; BENZALKONIUM CHLORIDE; CHLORHEXIDINE; MICROBICIDE; PLACEBO;

CLINICAL TRIAL; CONFIDENCE INTERVAL; DISEASE TRANSMISSION; DISINFECTION; DRUG CAPSULE; DRUG FORMULATION; DRUG TOLERABILITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MANTEL HAENSZEL TEST; NEWBORN DEATH; RANDOMIZED CONTROLLED TRIAL; REVIEW; RISK ASSESSMENT; RISK BENEFIT ANALYSIS; RISK REDUCTION; SYSTEMATIC REVIEW; UNSPECIFIED SIDE EFFECT; VAGINAL LAVAGE; VIRUS TRANSMISSION;

ADMINISTRATION, INTRAVAGINAL; ANTI-INFECTIVE AGENTS, LOCAL; DISEASE TRANSMISSION, VERTICAL; FEMALE; HIV INFECTIONS; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; RANDOMIZED CONTROLLED TRIALS;

EID: 34547102266     PISSN: 02569574     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (20)

1. Joint United Nations Programme on HIV/AIDS. AIDS Epidemic update (December 2005). www.unaids.org/epi/2005/doc/EPIupdate2005_html_en/ epi05_00_en.htm (accessed 6 February 2006).
2. De Cock KM, Fowler MG, Mercier E, et al. Prevention of mother-to-child HIV transmission in resource-poor countries: translating research into policy and practice. JAMA 2000; 283: 1175-1182.
3. Bilous J, Eggers R, Gasse F, et al. A new global immunisation vision and strategy. Lancet 2006; 367: 1464-1466.
4. Newell ML, Thorne C. Antiretroviral therapy and mother-to-child transmission of HIV-1. Expert Rev Anti Infect Ther 2004; 2: 717-732.
5. Brocklehurst P, Volmink J. Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection (Cochrane Review). In: The Cochrane Library, Issue 1, 2006. Chichester, UK: John Wiley & Sons.
6. De Cock KM, Bunnell R, Mermin J. Unfinished bussiness - expanding HIV testing in developing countries. N Engl J Med 2006; 354: 440-442.
7. Newell ML. Mechanisms and timing of mother-to-child transmission of HIV-1. AIDS 1998; 2: 831-837.
8. Goedert JJ, Duliege AM, Amos CI, Felton S, Biggar RJ. High risk of HIV-1 infection for first-born twins. Lancet 1991; 338: 1471-1475.
9. Duliege AM, Amos CI, Felton S, Biggar RJ, Goedert JJ. Birth order, delivery route and concordance in the transmission of human immunodeficiency virus type 1 from mothers to twins. J Pediatr 1995; 216: 625-632
10. Read JS, Newell ML. Efficacy and safety of cesarean delivery for prevention of mother-to-child transmission of HIV-1. The Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD005479. DOI: 10.1002/14651858.CD005479.
11. Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions 4.2.4 [updated Match 2005]. Cochrane Reviewers' Handbook 4.2.2 [updated December 2003]. http://www.cochrane.org/resources/ handbook/hbook.htm (accessed 11 July 2005).
12. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959; 22: 719-748.
13. Wiysonge CS, Shey MS, Shang JD, Sterne JAC, Broddehurst P. Vaginal disinfection for preventing mother-to-child transmission of HIV infection. The Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD003651. DOI: 10.1002/14651858.CD003651.pub2.
14. Taha TE, Justesen A, Paterson K, et al. An intervention to reduce the risk of mother-to-infant HIV transmission: results of a pilot toxicity study. East Afr Med J 1994; 71: 712-715.
15. Biggar RJ, Miotti PG, Taha TE, et al. Perinatal intervention trial in Africa: effect of a birth canal cleansing intervention to prevent HIV transmission. Lancet 1996; 347: 1647-1650.
16. Taha TE, Biggar RJ, Broadhead RL, et al. Effect of cleansing the birth canal with antiseptic solution on maternal and newborn morbidity and mortality in Malawi: clinical trial. BMJ 1997; 315: 216-220
17. Msellati P, Meda N, Leroy V, et al. Safety and acceptability of vaginal disinfection with benzalkonium chloride in HIV infected pregnant women in west Africa: ANRS 049b phase II randomized, double blinded placebo controlled trial. DITRAME Study Group. Sex Transm Infect 1999; 75: 420-425.
18. Mandelbrot L, Msellati P, Meda N, et al.; ANRS 049 Ditrame Study Group. 15 month follow up of African children following vaginal cleansing with benzalkonium chloride of their HIV infected mothers during late pregnancy and delivery. Sex Transm Infect 2002; 78: 267-270.
19. Gaillard P, Mwanyumba F, Verhofstede C, et al. Vaginal lavage with chlorhexidine during labour to reduce mother-to-child HIV transmission: clinical trial in Mombasa, Kenya. AIDS 2001; 15: 389-396.
20. Wilson CM, Gray G, Read JS, et al. Tolerance and safety of different concentrations of chlorhexidine for peripartum vaginal and infant washes: HIVNET 025. J Acquir Immune Defic Syndr 2004; 35: 138-143.