The inhibition of α-amanitin uptake in perfused rat liver

Advances in Clinical and Experimental Medicine

Volumn 16, Issue 3, 2007, Pages 353-360

  Magdalan, Jan ^a   Pieśniewska, Małgorzata ^a   Gliniak, Halina ^a  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

Author keywords

amanitin uptake; Extracorporeal rat liver perfusion; Inhibitors

Indexed keywords

ACETYLCYSTEINE; ALPHA AMANITIN; BROMSULFOPHTHALEIN; CEFTAZIDIME; ESTRADIOL; PENICILLIN G; RIFAMYCIN; SILIBININ; TAUROCHOLIC ACID;

AMANITA PHALLOIDES; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; LIVER CELL; LIVER FAILURE; LIVER PERFUSION; MALE; MUSHROOM POISONING; NONHUMAN; RAT; SPECIES DIFFERENCE; XENOBIOTIC METABOLISM;

AMANITA PHALLOIDES; ANIMALIA; BASIDIOMYCOTA; RATTUS; RATTUS NORVEGICUS;

EID: 34547101999     PISSN: 1230025X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Schneider SM: Mushrooms In: Clinical Toxicology. Eds.: Ford MD, Delaney KA, Ling LJ, Erickson WB, Saunders Company, Philadelphia, London, New York, St. Louis, Sydney, Toronto 2001, 1st ed, 899-909.
2. Ellenhorn M: Ellenhorn's Medical Toxicology. Diagnosis and Treatment of Human Poisoning. Williams & Wilkins, Baltimore 1997, 2nd ed., 1880-1896.
3. Manoguerra A: Mushrooms, Cyclopeptide. In: Encyclopedia of Toxicology. Chemical and concepts. Ed.: Wexler P, Academic Press 1988, t. II, 355-357.
4. Szajewski J: Zatrucia substancjami pochodzenia biologicznego. In: Choroby wewnetrzne. Eds.: Szczeklik A, Medycyna Praktyczna, Kraków 2006, 2239-2256.
5. Enjalbert A, Rapior S, Nouguier-Soule J, Guillon S, Amoroux N, Cabot C: Treatment of Amatoxin Poisoning: 20-Year Retrospective Analysis. J Toxicol Clin Toxicol 2002, 40, 715-757.
6. Klawitter M: Grzyby wywołujace zatrucia cytotropowe. W: Zatrucia roślinami wyższymi i grzybami. Red.: Henneberg M, Skrzydlewska E, PZWL, Warszawa 1984, 306-311.
7. Letschert K, Faulstich H, Keller D, Keppler D: Molecular characterization and inhibition of amanitin uptake into human hepatocytes. Toxicol Sci 2006, 91,140-149.
8. Nguyen V, Giannoni F, Dubois M, Seo S, Vigneron M, Kedinger C, Bensaude O: In vivo degradation of RNA polymerase II largest subunit triggered by alpha-amanitin. Nucleic Acids Res 1996, 24, 2924-2929.
9. Rudd M, Luse D: Amanitin greatly reduces the rate of transcription by RNA polymerase II ternary complexes but fails to inhibit some transcript cleavage modes. J Biol Chem 1996, 271, 21549-21558.
10. Jaeger A, Jehl F, Flesch F, Sauder P, Kopferschmitt J: Kinetics of amatoxins in human poisoning: therapeutic implications. J Toxicol Clin Toxicol 1993, 31, 63-80.
11. Cattori V, van Montfoort JE, Stieger B, Landmann L, Meijer DKF, Winterhalter KH, Meier PJ, Hagenbuch B: Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2, and Oatp3. Pflügers Arch - Europ J Physiol 2001, 443, 188-195.
12. Vetulani J: Appendix. In: Farmakometria. Doświadczalne metody badania leków. Eds.: Rump S, Kleinrok Z, PZWL, Warszawa 1982, 353-375.
13. Hovarth T: Basic Statistics for Behavioral Sciences. Little, Brown and Company, Boston, Toronto 1985, 145-249.
14. Kröncke K, Fricker G, Meier P, Gerok W, Wieland T, Kurz G: α-Amanitin Uptake into Hepatocytes. Identification of Hepatic Membrane Transport Systems used by Amatoxins. J Biol Chem 1986, 261, 12562-12567.
15. Naftel K, Keusch G, Gottagnoud P, Widmer U, Hany M, Gautschi K, Joos B, Walt H: Are cefalosporins more active than penicillin G in poisoning with the deadly Amanita? Schweiz Med Wochenschr 1988, 118, 49-51.
16. Naftel K, Hübscher U: Effects of β-Lactam Antibiotics on Proliferating Eucariotic Cells. Antimicrob Agents Chemother 1987, 31, 1657-1661.
17. Umezawa H, Mizuno S, Yamazaki H, Nitta K: Inhibition of DNA-dependent RNA synthesis by rifampycins. J Antibiotics 1968, 21, 234-236.
18. Wehrli W, Staehelin M: The rifamycins-relation of chemical structure and action on RNA polymerase. Biochim Biophys Acta 1969, 182, 24-29.
19. Fattinger K, Cattori V, Hagenbuch B, Meier P, Stieger B: Rifamycin SV and rifampicin exhibit differential inhibition of the hepatic rat organic anion transporting polypeptides, Oatp1 and Oatp2. Hepatology 2000, 32, 82-86.
20. Kim YC, Kim EJ, Lee ED, Kim JH, Jang SW, Kim YG, Kwon JW, Kim WB, Lee MG: Comparative bioavailability of silibinin in healthy male volunteers. Int J Clin Pharmacol Ther 2003, 41,593-596.
21. Faulstich H, Jahn W, Wieland T: Silybin inhibition of amatoxin uptake in the perfused rat liver. Arzneimittelforschung 1980, 30, 452-454.
22. Anker A: Acetaminophen In: Clinical Toxicology. Eds.: Ford MD, Delaney KA, Ling LJ, Erickson WB, Saunders Company, philadelphia, London, New York, St. Louis, Sydney, Toronto 2001, 1st ed, 265-274.
23. Zheleva A, Gadjeva V, Zhelev M: Free radical formation might contribute to the severe amatoxin hepatotoxicity. Trakia J Sci 2003, 1, 42-45.