Secondary metabolites in Hypericum perfoliatum: Variation among plant parts and phenological stages

Botanica Helvetica

Volumn 117, Issue 1, 2007, Pages 29-36

  Çirak, Cüneyt ^a   Radušienė, Jolita ^b   Janulis, Valdimaras ^c   Ivanauskas, Liudas ^c  

^a ONDOKUZ MAYIS UNIVERSITY   (Turkey)

^b INSTITUTE OF BOTANY   (Lithuania)

^c KAUNAS UNIVERSITY OF MEDICINE   (Lithuania)

Author keywords

Apigenin 7 O glucoside; Hypericin; Morphogenetic variation; Phenology; Rutin; Secondary chemistry

Indexed keywords

DICOTYLEDON; LIQUID CHROMATOGRAPHY; MEDICINAL PLANT; PHENOLOGY; SECONDARY METABOLITE;

EURASIA; TURKEY;

HYPERICUM; HYPERICUM PERFOLIATUM; HYPERICUM PERFORATUM;

EID: 34547092678     PISSN: 02531453     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00035-007-0777-z     Document Type: Article

References (35)

1. Abreu I.N., Porto A.L.M., Marsaioli A.J. and Mazzafera P. 2004. Distribution of bioactive substances from Hypericum brasiliense during plant growth. Plant Sci. 167: 949-954.
2. Ayan A.K., Çirak C., Kevseroǧlu K. and Özen T. 2004. Hypericin in some Hypericum species from Turkey. Asian J. Plant. Sci. 3: 200-202.
3. Benkiki N., Kabouche Z., Tillequin F., Verite P., Chosson E. and Seguin E. 2003. A new polyisoprenylated phloroglucinol derivative from Hypericum perfoliatum (Clusiaceae). Z Nat.forsch. [C] 58: 655-658.
4. Butterweck V., Jurgenliemk G., Nahrstedt A. and Winterhoff H. 2000. Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test. Planta Med. 66: 3-6.
5. Chu Y.H., Chang C.L. and Hsu H.F. 2000. Flavonoid content of several vegetables and their antioxidant activity. J. Sci. Food. Agric. 80: 561-566.
6. Ciccarelli D., Andreucci A.C. and Pagni A.M. 2001. Translucent glands and secretory canals in Hypericum perforatum. Morphological, anatomical and histochemical studies during the course of ontogenesis. Ann. Bot. 88: 637-644.
7. Couceiro M.A., Afreen F., Zobayed S.M.A. and Kozai T. 2006. Variation in concentrations of major bioactive compounds of St. John's wort: Effects of harvesting time, temperature and germplasm. Plant Sci. 170: 128-134.
8. Couladis M., Baziou P., Petrakis P.V. and Harvala C. 2001. Essential oil composition of Hypericum perfoliatum L. growing in different locations in Greece. Flavour Frag. J. 16: 204-206.
9. Çirak C., Saǧlam B., Ayan A.K. and Kevseroǧlu K. 2006. Morphogenetic and diurnal variation of hypericin in some Hypericum species from Turkey during the course of ontogenesis. Biochem. Syst. Ecol. 34: 1-13.
10. Davis P.H. 1988. Flora of Turkey and the East Aegean Islands. Edinburgh University Press, Edinburgh.
11. Dias A.C.P., Seabra R.M., Andrade P.B., Ferreres F. and Fernandes-Ferreria M. 2000. Xanthone biosynthesis and accumulation in calli and suspended cells of Hypericum androsaemum. Plant Sci. 150: 93-101.
12. Du H., Bay B.H., Mahendran R. and Olivo M. 2006. Hypericin-mediated photodynamic therapy elicits differential interleukin-6 response in nasopharyngeal cancer. Cancer Letters 235: 202-208.
13. Gastpar M. und Zeller K. 2005. Hypericum-Extrakt STW3 und Sertralin zur Behandlung der mittelschweren Depression. Psychopharmakotherapie 12: 146-153.
14. Jensen K.I.N., Gaul O.S., Specht E.G. and Doohan D.J. 1995. Hypericin content of Nova Scotia genotypes of Hypericum perforatum L. Can. J. Plant Sci. 75: 923-926.
15. Kazlauskas S. and Bagdonaite E. 2004. Quantitative analysis of active substances in St. John's wort (Hypericum perforatum L.) by the high performance liquid chromatography method. Medicina (Kaunas) 40: 975-981.
16. Kirakosyan A., Gibson D. and Sirvent T. 2003. Comperative survey of Hypericum perforatum plants as sources of hypericins and hyperforin. Journal of Herbs, Species, and Medicinal Plants 10: 110-122.
17. Kitanov G.M. 2001. Hypericin and pseudohypericin in some Hypericum species. Biochem. Syst. Ecol. 29: 171-178.
18. Kovacs G., Kuzovkina I.N., Szoke E. and Kursinszki L. 2004. HPLC determination of flavonoids in hairy-root cultures of Scutellaria baicalensis Georgi. Chromatographia 60: 81-85.
19. Kurth H. and Spreemann R. 1998. Phytochemical characterization of various St. John's wort extracts. Adv. Ther. 15: 117-128.
20. Maggi F., Ferretti G., Pocceschi N., Menghini L. and Ricciutelli M. 2004. Morphological, histochemical and phytochemical investigation of the genus Hypericum of the Central Italy. Fitoterapia 75: 702-711.
21. Martonfi P. and Repçak M. 1994. Secondary metabolites during flower ontogenesis of Hypericum perforatum L. Zahradnictvi 21: 37-44.
22. Medina M.A., Martínez-Poveda B., Amores-Sánchez M.I. and Quesada A.R. 2006. Hyperforin: More than an antidepressant bioactive compound? Life Sci. 79: 105-111.
23. Michelitsch A., Biza B., Wurglics M., Schubert-Zsilavecz M., Baumeister A. and Likussar W. 2000. Determination of hypericin in herbal medicine products by differential pulse polarography. Phytochem. Anal. 11: 41-44.
24. Noldner M. and Schotz K. 2002. Rutin is essential for the antidepressant activity of Hypericum perforatum extracts in the forced swimming test. Planta Med. 68: 577-80.
25. Özen T., Ayan A.K., Çirak C. and Kevseroǧlu K. 2005. Total phenol content of some Hypericum species growing in Turkey. Chem. Nat. Compd. 41: 232-233.
26. Patocka J. 2003. The chemistry, pharmacology, and toxicology of the biologically active constituents of the herb Hypericum perforatum L. J. Appl. Biomed. 1: 61-73.
27. Pharmeuropa 2004. St. John's wort dry extract, quantified. 16: 97-98.
28. Radusiene J., Bagdonaite E. and Kazlauskas S. 2004. Morphological and chemical evaluation on Hypericum perforatum and H. maculatum in Lithuania. Acta Hort. (ISHS) 629: 55-62.
29. Robson N.K.B. 1981. Studies in the genus Hypericum L. (Guttiferae). 2. Characters of the genus. Bull. Br. Mus. Nat. Hist. (Bot) 8: 55-226.
30. Sirvent T., Walker L., Vance N. and Donna G. 2002. Variation in hypericins from wild populations of Hypericum perforatum L. in the Pasific Northwest of the U.S.A. Econ. Bot. 56: 41-49.
31. Southwell I.A. and Campbell M.H. 1991. Hypericin content variation in Hypericum perforatum L. in Australia. Phytochemistry 30: 475-478.
32. Southwell I.A. and Bourke C.A. 2001. Seasonal variation in hypericin content of Hypericum perforatum L. (St. John's wort). Phytochemistry 56: 437-441.
33. Tekel'ova D., Repçak M., Zemkova E. and Toth J. 2000. Quantitative changes of dianthrones, hyperforin and flavonoids content in the flower ontogenesis of Hypericum perforatum. Planta Med. 66: 778-780.
34. Uzdensky A., Iani V., Ma L.W. and Moan J. 2006. On hypericin application in fluorescence diagnosis and cancer treatment: Pharmacokinetics and photosensitizing efficiency in nude mice bearing WiDr carcinoma. Med. Laser Appl. 21: 271-276.
35. Walker L., Sirvent T., Gibson D. and Vance N. 2001. Regional differences in hypericin and pseudohypericin concentrations and five morphological traits among Hypericum perforatum plants in the North-western United States. Can. J. Bot. 79: 1248-1255.