Targeting of Vulnerable Plaque Macrophages with Polymer-Based Nanostructures

Trends in Cardiovascular Medicine

Volumn 17, Issue 6, 2007, Pages 190-196

  Broz, Pavel ^a   Marsch, Stephan ^a   Hunziker, Patrick ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; FUMAGILLIN; MACROGOL; NANOMATERIAL; NANOPARTICLE; PHOTOSENSITIZING AGENT; POLY(METHYLOXAZOLINE); POLY[N (HYDROXYPROPYL)METHACRYLAMIDE]; POLYGLACTIN; POLYMER; SUPERPARAMAGNETIC IRON OXIDE; TETRAPHENYLPORPHOLACTOL; UNCLASSIFIED DRUG;

ATHEROSCLEROTIC PLAQUE; BIOCOMPATIBILITY; BIODEGRADATION; CONJUGATE; CONTRAST ENHANCEMENT; DIAGNOSTIC VALUE; DRUG DEGRADATION; DRUG DESIGN; DRUG HALF LIFE; HUMAN; MACROPHAGE; MICELLE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARTICLE SIZE; PRIORITY JOURNAL; RESTENOSIS; REVIEW; RISK FACTOR;

ABSORBABLE IMPLANTS; ARTERIOSCLEROSIS; DRUG DELIVERY SYSTEMS; HUMANS; MACROPHAGES; NANOSTRUCTURES; POLYMERS; RISK FACTORS;

EID: 34447648380     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcm.2007.05.002     Document Type: Review

References (44)

1. Aikawa E., Nahrendorf M., Sosnovik D., et al. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation 115 (2007) 377-386
2. Broz P., Benito S.M., Saw C., et al. Cell targeting by a generic receptor-targeted polymer nanocontainer platform. J Control Release 102 (2005) 475-488
3. Broz P., Driamov S., Ziegler J., et al. Toward intelligent nanosize bioreactors: a pH-switchable, channel-equipped, functional polymer nanocontainer. Nano Lett 6 (2006) 2349-2353
4. Bulmus V., Woodward M., Lin L., et al. A new pH-responsive and glutathione-reactive, endosomal membrane-disruptive polymeric carrier for intracellular delivery of biomolecular drugs. J Control Release 93 (2003) 105-120
5. Chen J.W., Querol Sans M., Bogdanov A., et al. Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates. Radiology 240 (2006) 473-481
6. Choi S.-H., Chae A., Chen C.H., et al. Emerging approaches for imaging vulnerable plaques in patients. Curr Opin Biotechnol 18 (2007) 73-82
7. Cohen-Sela E., Rosenzweig O., Gao J., et al. Alendronate-loaded nanoparticles deplete monocytes and attenuate restenosis. J Control Release 113 (2006) 23-30
8. Corti R., Fuster V., Fayad Z.A., et al. Lipid lowering by simvastatin induces regression of human atherosclerotic lesions: two years' follow-up by high-resolution noninvasive magnetic resonance imaging. Circulation 106 (2002) 2884-2887
9. Davies J.R., Rudd J.H.F., Weissberg P.L., et al. Radionuclide imaging for the detection of inflammation in vulnerable plaques. J Am Coll Cardiol 47 (2006) C57-C68
10. DeMaria A.N., Narula J., Mahmud E., et al. Imaging vulnerable plaque by ultrasound. J Am Coll Cardiol 47 (2006) C32-C39
11. Discher D.E., and Eisenberg A. Polymer vesicles. Science 297 (2002) 967-973
12. Duncan R., and Izzo L. Dendrimer biocompatibility and toxicity. Adv Drug Deliv Rev 57 (2005) 2215-2237
13. Farokhzad O.C., Cheng J., Teply B.A., et al. Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. PNAS 103 (2006) 6315-6320
14. Frias J.C., Ma Y., Williams K.J., et al. Properties of a versatile nanoparticle platform contrast agent to image and characterize atherosclerotic plaques by magnetic resonance imaging. Nano Lett 6 (2006) 2220-2224
15. Fuster V., Badimon L., Badimon J.J., et al. The pathogenesis of coronary artery disease and the acute coronary syndromes (1). N Engl J Med 326 (1992) 242-250
16. Fuster V., Badimon L., Badimon J.J., et al. The pathogenesis of coronary artery disease and the acute coronary syndromes (2). N Engl J Med 326 (1992) 310-318
17. Hansson G.K. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 352 (2005) 1685-1695
18. Hyafil F., Cornily J.C., Feig J.E., et al. Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography. Nat Med 13 (2007) 636-641
19. Jaffer F.A., Libby P., and Weissleder R. Molecular and cellular imaging of atherosclerosis: emerging applications. J Am Coll Cardiol 47 (2006) 1328-1338
20. Jaffer F.A., Sosnovik D.E., Nahrendorf M., et al. Molecular imaging of myocardial infarction. J Mol Cell Cardiol 41 (2006) 921-933
21. Kawasaki M., Bouma B.E., Bressner J., et al. Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaques. J Am Coll Cardiol 48 (2006) 81-88
22. Kita-Tokarczyk K., Grumelard J., Haefele T., et al. Block copolymer vesicles-using concepts from polymer chemistry to mimic biomembranes. Polymer 46 (2005) 3540-3563
23. Lanza G., Winter P., Cyrus T., et al. Nanomedicine opportunities in cardiology. Ann NY Acad Sci 1080 (2006) 451-465
24. Lanza G.M., Winter P.M., Caruthers S.D., et al. Magnetic resonance molecular imaging with nanoparticles. J Nucl Cardiol 11 (2004) 733-743
25. Litovsky S., Madjid M., and Zarrabi A. Superparamagnetic iron oxide-based method for quantifying recruitment of monocytes to mouse atherosclerotic lesions in vivo: enhancement by tissue necrosis factor-{alpha}, interleukin-1{beta}, and interferon-{gamma}. Circulation 107 (2003) 1545-1549
26. Madjid M., Willerson J.T., and Casscells S.W. Intracoronary thermography for detection of high-risk vulnerable plaques. J Am Coll Cardiol 47 (2006) C80-C85
27. McCarthy J.R., Jaffer F.A., and Weissleder R. A macrophage-targeted theranostic nanoparticle for biomedical applications. Small 2 (2006) 983-987
28. McCarthy J.R., Perez J.M., Bruckner C., et al. Polymeric nanoparticle preparation that eradicates tumors. Nano Lett 5 (2005) 2552-2556
29. Moghimi S.M., Hunter A.C., and Murray J.C. Nanomedicine: current status and future prospects. FASEB J 19 (2005) 311-330
30. Moghimi S.M., and Szebeni J. Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties. Prog Lipid Res 42 (2003) 463-478
31. Nahrendorf M., Jaffer F.A., Kelly K.A., et al. Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. Circulation 114 (2006) 1504-1511
32. Owens D.E., and Peppas N.A. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J Pharm 307 (2006) 93-102
33. Pande A.N., Kohler R.H., Aikawa E., et al. Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy. J Biomed Opt 11 (2006) 021009 7 pages
34. Perez J.M., Josephson L., O'Loughlin T., et al. Magnetic relaxation switches capable of sensing molecular interactions. Nat Biotechnol 20 (2002) 816-820
35. Ranquin A., Versees W., Meier W., et al. Therapeutic nanoreactors: combining chemistry and biology in a novel triblock copolymer drug delivery system. Nano Lett 5 (2005) 2220-2224
36. Ruehm S.G., Corot C., Vogt P., et al. Ultrasmall superparamagnetic iron oxide-enhanced MR Imaging of atherosclerotic plaque in hyperlipidemic rabbits. Acad Radiol 9 (2002) S143-S144
37. Sosnovik D.E., Nahrendorf M., and Weissleder R. Molecular magnetic resonance imaging in cardiovascular medicine. Circulation 115 (2007) 2076-2086
38. Stefanadis C., Vavuranakis M., and Toutouzas P. Vulnerable plaque: the challenge toidentify and treat it. J Interv Cardiol 16 (2003) 273-280
39. Waxman S., Ishibashi F., and Muller J.E. Detection and treatment of vulnerable plaques and vulnerable patients: novel approaches to prevention of coronary events. Circulation 114 (2006) 2390-2411
40. Weissleder R., Kelly K., Sun E.Y., et al. Cell-specific targeting of nanoparticles by multivalent attachment of small molecules. Nat Biotechnol 23 (2005) 1418-1423
41. Wickline S.A., and Lanza G.M. Nanotechnology for molecular imaging and targeted therapy. Circulation 107 (2003) 1092-1095
42. Wilensky R.L., Song H.K., and Ferrari V.A. Role of magnetic resonance and intravascular magnetic resonance in the detection of vulnerable plaques. J Am Coll Cardiol 47 (2006) C48-C56
43. Winter P.M., Neubauer A.M., Caruthers S.D., et al. Endothelial alpha(v)beta3 integrin-targeted fumagillin nanoparticles inhibit angiogenesis in atherosclerosis. Arterioscler Thromb Vasc Biol 26 (2006) 2103-2109
44. Woodle M.C., Engbers C.M., and Zalipsky S. New amphipathic polymer-lipid conjugates forming long-circulating reticuloendothelial system-evading liposomes. Bioconjug Chem 5 (1994) 493-496