Human neural progenitor cell transplants into the subthalamic nucleus lead to functional recovery in a rat model of Parkinson's disease

Neurobiology of Disease

Volumn 27, Issue 2, 2007, Pages 133-140

  Anderson, Lucy ^a   Caldwell, Maeve A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

EGF; FGF2; Human neural stem cell; Laminin; Parkinson's disease; Subthalamic nucleus; Transplantation; VEGF

Indexed keywords

AMPHETAMINE; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; LAMININ; NESTIN; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CIRCLING BEHAVIOR; CONTROLLED STUDY; CONVALESCENCE; DISEASE MODEL; FEMALE; IMMUNOHISTOCHEMISTRY; NEURAL STEM CELL TRANSPLANTATION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SUBTHALAMIC NUCLEUS; SURVIVAL TIME;

ANIMALS; BRAIN TISSUE TRANSPLANTATION; DISEASE MODELS, ANIMAL; FEMALE; FETAL TISSUE TRANSPLANTATION; GRAFT SURVIVAL; HUMANS; IMMUNOHISTOCHEMISTRY; NEURONS; PARKINSONIAN DISORDERS; RATS; RECOVERY OF FUNCTION; STEM CELL TRANSPLANTATION; SUBTHALAMIC NUCLEUS;

EID: 34447642351     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2007.03.015     Document Type: Article

References (45)

1. Behrstock S., Ebert A., McHugh J., Vosberg S., Moore J., Schneider B., Capowski E., Hei D., Kordower J., Aebischer P., and Svendsen C.N. Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates. Gene Ther. 13 (2006) 379-388
2. Benabid A.L. Deep brain stimulation for Parkinson's disease. Curr. Opin. Neurobiol. 13 (2003) 696-706
3. Benabid A.L., Deuschl G., Lang A.E., Lyons K.E., and Rezai A.R. Deep brain stimulation for Parkinson's disease. Mov. Disord. 21 (2006) S168-S170
4. 2 receptors. Neuropharmacology 46 (2004) 974-983
5. Burnstein R.M., Foltynie T., He X., Menon D.K., Svendsen C.N., and Caldwell M.A. Differentiation and migration of long term expanded human neural progenitors in a partial lesion model of Parkinson's disease. Int. J. Biochem. Cell Biol. 36 (2004) 702-713
6. Caldwell M.A., He X., Wilkie N., Pollack S., Marshall G., Wafford K.A., and Svendsen C.N. Growth factors regulate the survival and fate of cells derived from human neurospheres. Nat. Biotechnol. 19 (2001) 475-479
7. Carpenter M.K., Cui X., Hu Z.Y., Jackson J., Sherman S., Seiger A., and Wahlberg L.U. In vitro expansion of a multipotent population of human neural progenitor cells. Exp. Neurol. 158 (1999) 265-278
8. Carvalho G.A., and Nikkhah G. Subthalamic nucleus lesions are neuroprotective against terminal 6-OHDA-induced striatal lesions and restore postural balancing reactions. Exp. Neurol. 171 (2001) 405-417
9. Chandran S., Compston A., Jauniaux E., Gilson J., Blakemore W., and Svendsen C. Differential generation of oligodendrocytes from human and rodent embryonic spinal cord neural precursors. Glia 47 (2004) 314-324
10. Dunnett S.B., Bjorklund A., and Lindvall O. Cell therapy in Parkinson's disease - stop or go?. Nat. Rev., Neurosci. 2 (2001) 365-369
11. Emborg M.E. Evaluation of animal models of Parkinson's disease for neuroprotective strategies. J. Neurosci. Methods 139 (2004) 121-143
12. Englund U., Bjorklund A., and Wictorin K. Migration patterns and phenotypic differentiation of long-term expanded human neural progenitor cells after transplantation into the adult rat brain. Brain Res. Dev. Brain Res. 134 (2002) 123-141
13. Englund U., Fricker-Gates R.A., Lundberg C., Bjorklund A., and Wictorin K. Transplantation of human neural progenitor cells into the neonatal rat brain: extensive migration and differentiation with long-distance axonal projections. Exp. Neurol. 173 (2002) 1-21
14. Fricker R.A., Carpenter M.K., Winkler C., Greco C., Gates M.A., and Bjorklund A. Site-specific migration and neuronal differentiation of human neural progenitor cells after transplantation in the adult rat brain. J. Neurosci. 19 (1999) 5990-6005
15. Garcia L., D'Alessandro G., Bioulac B., and Hammond C. High-frequency stimulation in Parkinson's disease: more or less?. Trends Neurosci. 28 (2005) 209-216
16. Harrower T.P., Tyers P., Hooks Y., and Barker R.A. Long-term survival and integration of porcine expanded neural precursor cell grafts in a rat model of Parkinson's disease. Exp. Neurol. 197 (2006) 56-69
17. Henderson J.M., Annett L.E., Ryan L.J., Chiang W., Hidaka S., Torres E.M., and Dunnett S.B. Subthalamic nucleus lesions induce deficits as well as benefits in the hemiparkinsonian rat. Eur. J. Neurosci. 11 (1999) 2749-2757
18. Jin K.L., Mao X.O., and Greenberg D.A. Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 10242-10247
19. Li J., Imitola J., Snyder E.Y., and Sidman R.L. Neural stem cells rescue nervous Purkinje neurons by restoring molecular homeostasis of tissue plasminogen activator and downstream targets. J. Neurosci. 26 (2006) 7839-7848
20. Lindvall O., Kokaia Z., and Martinez-Serrano A. Stem cell therapy for human neurodegenerative disorders - how to make it work. Nat. Med. 10 (2004) S42-S50 Suppl
21. Lozano A.M., Dostrovsky J., Chen R., and Ashby P. Deep brain stimulation for Parkinson's disease: disrupting the disruption. Lancet Neurol. 1 (2002) 225-231
22. Madhavan L., Ourednik V., and Ourednik J. Grafted neural stem cells shield the host environment from oxidative stress. Ann. N. Y Acad Sci. 1049 (2005) 185-188
23. Maesawa S., Kaneoke Y., Kajita Y., Usui N., Misawa N., Nakayama A., and Yoshida J. Long-term stimulation of the subthalamic nucleus in hemiparkinsonian rats: neuroprotection of dopaminergic neurons. J. Neurosurg. 100 (2004) 679-687
24. Maurer M.H., Tripps W.K., Feldmann Jr. R.E., and Kuschinsky W. Expression of vascular endothelial growth factor and its receptors in rat neural stem cells. Neurosci. Lett. 344 (2003) 165-168
25. Mendez I., Baker K.A., and Hong M. Simultaneous intrastriatal and intranigral grafting (double grafts) in the rat model of Parkinson's disease. Brain Res. Brain Res. Rev. 32 (2000) 328-339
26. Mukhida K., Baker K.A., Sadi D., and Mendez I. Enhancement of sensorimotor behavioral recovery in hemiparkinsonian rats with intrastriatal, intranigral, and intrasubthalamic nucleus dopaminergic transplants. J. Neurosci. 21 (2001) 3521-3530
27. Nikkhah G., Bentlage C., Cunningham M.G., and Bjorklund A. Intranigral fetal dopamine grafts induce behavioral compensation in the rat Parkinson model. J. Neurosci. 14 (1994) 3449-3461
28. Obeso J.A., Rodriguez-Oroz M.C., Rodriguez M., Lanciego J.L., Artieda J., Gonzalo N., and Olanow C.W. Pathophysiology of the basal ganglia in Parkinson's disease. Trends Neurosci. 23 (2000) S8-S19
29. Olanow C.W., Kordower J.H., and Freeman T.B. Fetal nigral transplantation as a therapy for Parkinson's disease. Trends Neurosci. 19 (1996) 102-109
30. Olsson M., Nikkhah G., Bentlage C., and Bjorklund A. Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test. J. Neurosci. 15 (1995) 3863-3875
31. Ourednik V., and Ourednik J. Multifaceted dialogue between graft and host in neurotransplantation. J. Neurosci. Res. 76 (2004) 193-204
32. Ourednik J., Ourednik V., Lynch W.P., Schachner M., and Snyder E.Y. Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons. Nat. Biotechnol. 20 (2002) 1103-1110
33. Paul G., Meissner W., Rein S., Harnack D., Winter C., Hosmann K., Morgenstern R., and Kupsch A. Ablation of the subthalamic nucleus protects dopaminergic phenotype but not cell survival in a rat model of Parkinson's disease. Exp. Neurol. 185 (2004) 272-280
34. Phillips J.M., Latimer M.P., Gupta S., Winn P., and Brown V.J. Excitotoxic lesions of the subthalamic nucleus ameliorate asymmetry induced by striatal dopamine depletion in the rat. Behav. Brain Res. 90 (1998) 73-77
35. Piallat B., Benazzouz A., and Benabid A.L. Subthalamic nucleus lesion in rats prevents dopaminergic nigral neuron degeneration after striatal 6-OHDA injection: behavioural and immunohistochemical studies. Eur. J. Neurosci. 8 (1996) 1408-1414
36. Pluchino S., Quattrini A., Brambilla E., Gritti A., Salani G., Dina G., Galli R., del Carro U., Amadio S., Bergami A., Furlan R., Comi G., Vescovi A.L., and Martino G. Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature 422 (2003) 688-694
37. Pluchino S., Zanotti L., Rossi B., Brambilla E., Ottoboni L., Salani G., Martinello M., Cattalini A., Bergami A., Furlan R., Comi G., Constantin G., and Martino G. Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism. Nature 436 (2005) 266-271
38. Svendsen C.N., Caldwell M.A., Shen J., ter Borg M.G., Rosser A.E., Tyers P., Karmiol S., and Dunnett S.B. Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease. Exp. Neurol. 148 (1997) 135-146
39. Svendsen C.N., ter Borg M.G., Armstrong R.J., Rosser A.E., Chandran S., Ostenfeld T., and Caldwell M.A. A new method for the rapid and long term growth of human neural precursor cells. J. Neurosci. Methods 85 (1998) 141-152
40. Touchon J.C., Moore C., Frederickson J., and Meshul C.K. Lesion of subthalamic or motor thalamic nucleus in 6-hydroxydopamine-treated rats: effects on striatal glutamate and apomorphine-induced contralateral rotations. Synapse 51 (2004) 287-298
41. Ungerstedt U., and Arbuthnott G.W. Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system. Brain Res. 24 (1970) 485-493
42. Vescovi A.L., Parati E.A., Gritti A., Poulin P., Ferrario M., Wanke E., Frolichsthal-Schoeller P., Cova L., Arcellana-Panlilio M., Colombo A., and Galli R. Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation. Exp. Neurol. 156 (1999) 71-83
43. Wada K., Arai H., Takanashi M., Fukae J., Oizumi H., Yasuda T., Mizuno Y., and Mochizuki H. Expression levels of vascular endothelial growth factor and its receptors in Parkinson's disease. NeuroReport 17 (2006) 705-709
44. Winkler C., Fricker R.A., Gates M.A., Olsson M., Hammang J.P., Carpenter M.K., and Bjorklund A. Incorporation and glial differentiation of mouse EGF-responsive neural progenitor cells after transplantation into the embryonic rat brain. Mol. Cell. Neurosci. 11 (1998) 99-116
45. Zhu W., Mao Y., Zhao Y., Zhou L.F., Wang Y., Zhu J.H., Zhu Y., and Yang G.Y. Transplantation of vascular endothelial growth factor-transfected neural stem cells into the rat brain provides neuroprotection after transient focal cerebral ischemia. Neurosurgery 57 (2005) 325-333