Haptoglobin serum levels are independently associated with insulinemia in overweight and obese women

Journal of Endocrinological Investigation

Volumn 30, Issue 5, 2007, Pages 399-403

  De Pergola, G ^a,b   Di Roma, P ^a   Paoli, G ^a   Guida, P ^a   Pannacciulli, N ^a   Giorgino, R ^a  

^a UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

^b NONE   (Italy)

Author keywords

Haptoglobin; Insulin; Insulin resistance; Obesity

Indexed keywords

CHOLESTEROL; GLUCOSE; HAPTOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; TRIACYLGLYCEROL; BIOLOGICAL MARKER;

ADULT; AGE; AGED; ARTICLE; BODY FAT DISTRIBUTION; BODY MASS; CHOLESTEROL BLOOD LEVEL; CROSS-SECTIONAL STUDY; DIASTOLIC BLOOD PRESSURE; DIET RESTRICTION; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERINSULINEMIA; INDEPENDENT VARIABLE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULINEMIA; LIPID STORAGE; MAJOR CLINICAL STUDY; MULTIPLE REGRESSION; OBESITY; PROTEIN BLOOD LEVEL; STATISTICAL SIGNIFICANCE; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; WOMEN'S HEALTH; ADOLESCENT; BLOOD; BLOOD PRESSURE; BODY WEIGHT; HYPERINSULINISM; METABOLISM; MIDDLE AGED;

ADOLESCENT; ADULT; AGED; BIOLOGICAL MARKERS; BLOOD PRESSURE; BODY MASS INDEX; BODY WEIGHT; CROSS-SECTIONAL STUDIES; FEMALE; HAPTOGLOBINS; HUMANS; HYPERINSULINISM; MIDDLE AGED; OBESITY;

EID: 34447641967     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03346317     Document Type: Article

References (18)

1. Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 2003, 112: 1785-8.
2. Ridker PM. High-sensitivity C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease. Circulation 2001, 103: 1813-8.
3. Ridker PM. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation 2003. 107: 363-9.
4. Bensi G, Raugei G, Klefenz H, Cortese R. Structure and expression of the human haptoglobin locus. EMBO J 1985, 4: 119-26
5. Bowman BH, Kurosky A. Haptoglobin: the evolutionary product of duplication, unequal crossingover, and point mutation. Adv Hum Gen 1982, 12: 189-261.
6. Langlois MR, Delanghe JR. Biological and clinical significance of haptoglobin polymorphism in humans. Clin Chem 1996, 42: 1589-600.
7. Chiellini C, Santini F, Marsili A, et al. Serum haptoglobin: a novel marker of adiposity in humans. J Clin Endocrinol Metab 2004, 89: 2678-83.
8. Friedrichs WE, Navarijo-Ashbaug AL, Bowman BH, Yang F. Expression and inflammatory regulation of haptoglobin gene in adipocytes. Biochem Biophys Res Commun 1995, 209: 250-6.
9. Engstrom G, Hedblad B, Stanenow L, Lind P, Janzon L, Lindgarde F. Inflammation-sensitive plasma proteins are associated with future weight gain. Diabetes 2003, 52: 2097-101.
10. Engstrom G, Janzon L, Berglund G, et al. Blood pressure and incidence of hypertension in relation to inflammation-sensitive plasma proteins. Arterioscler Thromb Vac Biol 2002, 22: 2054-8.
11. Hannerz J, Greitz D, Ericson K. Is there a relationship between obesity and intracranial hypertension? Int J Obesity Relat Metab Disord 1995, 19: 240-4.
12. Montani JP, Antic V, Yang Z, Dulloo A. Pathways from obesity to hypertension: from the perspective of a vicious triangle. Int J Obes Relat Metab Disord 2002, 26: S28-38.
13. Engstrom G, Stavenow L, Hedblad B, et al. Infiammation-sensitive plasma proteins, diabetes, and mortality and incidence of myocardial infarction and stroke. A population-based study. Diabetes 2003, 52: 442-7.
14. Chiellini C, Bertacca A, Novelli SE, et al. Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha. J Cell Physiol 2002, 190: 251-8.
15. Fain JN, Bahouth SW, Madan AK. Haptoglobin release by human adipose tissue in primary culture. J Lipid Res 2004, 45: 536-42.
16. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997, 20: 1183-97.
17. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostatic model assessment: insulin resistance and β-cell function from fasting glucose and insulin concentrations in man. Diabetologia 1985, 28: 412-9.
18. Edwards DH, Griffith TM, Ryley HC, Henderson AH. Haptoglobin-haemoglobin complex in human plasma inhibits endotheliurn dependent relaxation: evidence that endothelium derived relaxing factor acts as a local autocoid. Cardiovasc Res 1986, 20: 549-56.