Effect of insulin on acetylcholine-evoked amylase release and calcium mobilization in streptozotocin-induced diabetic rat pancreatic acinar cells

Annals of the New York Academy of Sciences

Volumn 1084, Issue , 2006, Pages 58-70

  Patel, Rekha ^a   Pariente, José A ^b   Martinez, Maria A ^b   Salido, Ginés M ^b   Singh, Jaipaul ^a  

^a UNIVERSITY OF CENTRAL LANCASHIRE   (United Kingdom)

^b UNIVERSITY OF EXTREMADURA   (Spain)

Author keywords

Acetylcholine; Amylase; Calcium; Diabetes; Insulin; Rats

Indexed keywords

ACETYLCHOLINE; AMYLASE; CALCIUM ION; FURA 2; INSULIN;

ACINAR CELL; AMYLASE RELEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM MOBILIZATION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVATION; EVOKED RESPONSE; MALE; MOLECULAR MECHANICS; NONHUMAN; PANCREAS INSUFFICIENCY; RAT; STREPTOZOCIN DIABETES; ANIMAL; ARTICLE; CALCIUM SIGNALING; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; HISTOLOGY; ORGAN SIZE; PANCREAS; PATHOPHYSIOLOGY; PHYSIOLOGY; REFERENCE VALUE; SECRETION; WISTAR RAT;

RATTUS;

ACETYLCHOLINE; AMYLASES; ANIMALS; CALCIUM SIGNALING; DIABETES MELLITUS, EXPERIMENTAL; INSULIN; MALE; ORGAN SIZE; PANCREAS; RATS; RATS, WISTAR; REFERENCE VALUES;

EID: 34447635434     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1372.027     Document Type: Conference Paper

References (34)

1. WILLIAMS, J.A. & I.D. GOLDFINE. 1993. The insulin acinar relationship. In The Exocrine Pancreas: Biology, Pathobiology, and Disease, 2nd ed. V.L.M. Go, E.P. DiMagno, J.D. Gardner, et al., Eds.: 789-802. Raven Press. N.Y.
2. VANDER, A., J. SHERMAN & D. LUCIANO. The digestion and absorption of food. 1998. In Human Physiology, The Mechanisms of Body Function, 7th ed. A. Vander, J. Sherman & D. Luciano, Eds.: 551-556, 576-577. WCB McGraw-Hill. Boston.
3. RICHINS, C.A. 1945. The innervation of the pancreas. J. Comp. Neurol. 82: 223-236.
4. BROWN, J.H. & P.M. MCDONOUGH. 1989. Muscarinic cholinergic receptors of inositol phospholipids metabolism and calcium mobilization. In The Muscarinic Receptors. J.H. Brown, Ed.: 259-307. Humana Press. NJ.
5. BERRIDGE, M.J. 1993. Inositol trisphosphate and calcium signalling. Nature 361: 315-325.
6. PUTNEY, J.W., JR. 1988. The role of phosphoinositide metabolism in signal transduction in secretory cells. J. Exp. Biol. 139: 135-150.
7. JENSEN, R.T. & J.D. GARDNER. 1981. Identification and characterization of receptors for secretagogues on pancreatic acinar cells. Fed. Proc. 40: 2486-2496.
8. NISHIZUKA, Y. 1988. Studies and prospectives of protein kinase C in signal transduction. Nippon Ketsueki Gakkai Zasshi 51: 1321-1326.
9. SINGH, J. & E. ADEGHATE. 1998. Effects of islet hormones on nerve-mediated and acetylcholine-evoked secretory responses in the isolated pancreas of normal and diabetic rats. Int. J. Mol. Med. 1: 627-634.
10. JUMA, L.M., J. SINGH, D.J. PALLOT, et al. 1997. Interactions of islet hormones with acetylcholine in the isolated rat pancreas. Peptides 18: 1415-1422.
11. SINGH, J., E. ADEGHATE, S. APARICO, et al. 2004. Exocrine pancreatic insufficiency in diabetes mellitus. Int. J. Diabetes Metab. 12: 35-43.
12. PATEL, R., M.D. YAGO, M. MANAS, et al. 2004a. Mechanism of exocrine pancreatic insufficiency in streptozotocin-induced diabetes mellitus in rat: effect of cholecystokinin-octapeptide. Mol. Cell. Biochem. 261: 83-89.
13. SHARMA, A.K., I.G. DUGUID, D.S. BLANCHARD, et al. 1985. The effect of insulin treatment on myelinated nerve fibre maturation and integrity and on body growth in streptozotocin-diabetic rats. J. Neurol. Sci. 67: 285-297.
14. PARIENTE, J.A., P.C. REDONDO, M.P. GRANADOS, et al. 2003. Calcium signalling in non-excitable cells. E. C. Qua. L. 1: 29-43.
15. GARDNER, J.D. & M.J. JACKSON. 1977. Regulation of amylase release from dispersed pancreatic acinar cells. J. Physiol. 270: 439-454.
16. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260: 3440-3450.
17. PATEL, R., J. SINGH, M.D. YAGO, et al. 2004b. Effect of insulin on exocrine pancreatic secretion in healthy and diabetic anaesthetised rats. Mol. Cell. Biochem. 261: 105-110.
18. AHMED, I., E. ADEGHATE, A.K. SHARMA, et al. 1998. Effects of Momordica charantia fruit juice on islet morphology in the pancreas of the streptozotocin-diabetic rat. Diabetes Res. Clin. Pract. 40: 145-151.
19. SINGH, J., L.M.O. JUMA, E. ADEGHATE, et al. 1999. Interactive adaptation of endocrine and exocrine pancreas: effects of islet hormones and secretagogues. In Adaptation Biology and Medicine. K.B. Pandolf, N. Takeda & P.K. Singal, Eds.: 223-235. Narosa Publishing House. New Delhi, India.
20. SINGH, J., M.D. YAGO & E. ADEGHATE. 2001. Involvement of cellular calcium in exocrine pancreatic insufficiency during streptozotocin-induced diabetes mellitus. Arch. Physiol. Biochem. 109: 252-259.
21. KUMAR, P.J. & M.L. CLARK. 2002. Diabetes mellitus and other disorders of metabolism. In Clinical Medicine. P.J. Kumar & M.L. Clark, Eds.: 1069-1122. WB Saunders. London.
22. SOFRANKOVA, A. & G.J. DOCKRAY. 1983. Cholecystokinin- and secretin-induced pancreatic secretion in normal and diabetic rats. Am. J. Physiol. 244: G370-G374.
23. OTSUKI, M., T. AKIYAMA, H. SHIROHARA, et al. 1995. Loss of sensitivity to cholecystokinin stimulation of isolated pancreatic acini from genetically diabetic rats. Am. J. Physiol. 268: E531-E536.
24. YAGO, M.D., E. ADEGHATE & J. SINGH. 1999. Interactions between the endocrine and exocrine pancreas. Effects of islet hormones, secretagogues, and nerve stimulation. In Neural Regulation in the Vertebrate Endocrine System: Neuroendocrine Regulation. R.A. Prasada Rao, R. Peters Eds.: 197-217. Kluwer Academic/Plenum. N.Y.
25. MAHAY, S., E. ADEGHATE, M.Z. LINDLEY, et al. 2004. Streptozotocin-induced type 1 diabetes mellitus alters the morphology, secretory function and acyl lipid contents in the isolated rat parotid salivary gland. Mol. Cell. Biochem. 261: 175-181.
26. SINGH, J. & G.T. PEARSON. 1984. Effects of nerve stimulation on enzyme secretion from the in vitro rat pancreas and 3H-release after preincubation with catecholamines. Naunyn Schmiedebergs Arch Pharmacol. 327: 228-233.
27. KANNO, T. & A. SAITO. 1976. The potentiating influences of insulin on pancreozymin-induced hyperpolarization and amylase release in the pancreatic acinar cell. J. Physiol. 261: 505-521.
28. SAITO, A., J.A. WILLIAMS & T. KANNO. 1980a. Potentiation of cholecystokinin-induced exocrine secretion by both exogenous and endogenous insulin in isolated and perfused rat pancreata. J. Clin. Invest. 65: 777-782.
29. SAITO, A., J.A. WILLIAMS & T. KANNO. 1980b. Potentiation by insulin of acetylcholine-induced secretory response of the perfused rat pancreas. Biomed. Res. 1: 101-103.
30. YAGO, M.D., M. MANAS & J. SINGH. 2000. Intracellular magnesium: transport and regulation in epithelial secretory cells. Front. Biosci. 5: D602-D618.
31. DUAN, R.D. & C. ERLANSON-ALBERTSSON. 1990. Altered synthesis of some secretory proteins in pancreatic lobules isolated from streptozotocin-induced diabetic rats. Pancreas 5: 136-143.
32. DUAN, R.D. & C. ERLANSON-ALBERTSSON. 1992. The effect of pretranslational regulation on synthesis of pancreatic colipase in streptozotocin-induced diabetes in rats. Pancreas 7: 465-471.
33. YANG, Y.K. & W.Y. ZHU. 1995. Effect of insulin on the function of pancreatic exocrine. Sheng. Li. Xue. Bao. 47: 238-244.
34. BERRIDGE, M.J. 1995. Inositol trisphosphate and calcium signalling. Ann. N. Y. Acad. Sci. 766: 31-43.