The effects of hypoxia on load compensation during sustained incremental resistive loading in patients with obstructive sleep apnea

Journal of Applied Physiology

Volumn 103, Issue 1, 2007, Pages 234-239

  Hlavac, Michael C ^a,b,d   Catcheside, Peter G ^a,c   Adams, Amanda ^a   Eckert, Danny J ^a,c   McEvoy, R Doug ^a,b,c  

^a REPATRIATION GENERAL HOSPITAL   (Australia)

^b FLINDERS UNIVERSITY   (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

^d CHRISTCHURCH HOSPITAL   (New Zealand)

Author keywords

Inspiratory resistive loading; Sleep disordered breathing

Indexed keywords

ADULT; AMBIENT AIR; ARTERIAL OXYGEN SATURATION; ARTICLE; BREATHING; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HUMAN; HYPOXIA; LUNG MINUTE VOLUME; LUNG VENTILATION; MALE; PRIORITY JOURNAL; SLEEP APNEA SYNDROME; TIDAL VOLUME;

ADULT; AIRWAY RESISTANCE; ANOXIA; CASE-CONTROL STUDIES; FEMALE; HUMANS; INHALATION; MALE; MIDDLE AGED; PULMONARY VENTILATION; RESPIRATORY FUNCTION TESTS; SLEEP APNEA, OBSTRUCTIVE; TIDAL VOLUME; TIME FACTORS;

EID: 34447634325     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01618.2005     Document Type: Article

References (35)

1. Afifi L, Guilleminault C, Colrain IM. Sleep and respiratory stimulus specific dampening of cortical responsiveness in OSAS. Respir Physiol Neurobiol 136: 221-234, 2003.
2. American Academy of Sleep Medicine Task Force. Sleep-related breathing disorders in adults: recommendations for syndrome definition, and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep 22: 667-689, 1999.
3. American Sleep Disorders Association. EEG arousals: scoring rules, and examples: a preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. Sleep 15: 173-184, 1992.
4. Axen K. Ventilatory responses to mechanical loads in cervical cordinjured humans. J Appl Physiol 52: 748-756, 1982.
5. Axen K, Haas SS. Range of first-breath ventilatory responses to added mechanical loads in naive men. J Appl Physiol 46: 743-751, 1979.
6. Axen K, Haas SS, Haas F, Gaudino D, Haas A. Ventilatory adjustments during sustained mechanical loading in conscious humans. J Appl Physiol 55: 1211-1218, 1983.
7. Berry DT, McConnell JW, Phillips BA, Carswell CM, Lamb DG, Prine BC. Isocapnic hypoxemia and neuropsychological functioning. J Clin Exp Neuropsychol 11: 241-251, 1989.
8. Bruce EN, Smith JD, Grodins FS. Chemical and reflex drives to breathing during resistance loading in cats. J Appl Physiol 37: 176-182, 1974.
9. Daubenspeck JA, Bennett FM. Immediate human breathing pattern responses to loads near the perceptual threshold. J Appl Physiol 55: 1160-1166, 1983.
10. Easton PA, Slykerman LJ, Anthonisen NR. Recovery of the ventilatory response to hypoxia in normal adults. J Appl Physiol 64: 521-528, 1988.
11. Easton PA, Slykerman LJ, Anthonisen NR. Ventilatory response to sustained hypoxia in normal adults. J Appl Physiol 61: 906-911, 1986.
12. Eckert DJ, Catcheside PG, McDonald R, Adams AM, Webster KE, Hlavac MC, McEvoy RD. Sustained hypoxia depresses sensory processing of respiratory resistive loads. Am J Respir Crit Care Med 172: 1047-1054, 2005.
13. Eckert DJ, Catcheside PG, Smith JH, Frith PA, McEvoy RD. Hypoxia suppresses symptom perception in asthma. Am J Respir Crit Care Med 169: 1224-1230, 2004.
14. Engleman HM, Cheshire KE, Deary IJ, Douglas NJ. Daytime sleepiness, cognitive performance and mood after continuous positive airway pressure for the sleep apnoea/hypopnoea syndrome. Thorax 48: 911-914, 1993.
15. Engleman HM, Martin SE, Deary IJ, Douglas NJ. Effect of continuous positive airway pressure treatment on daytime function in sleep apnoea/hypopnoea syndrome. Lancet 343: 572-575, 1994.
16. Gora J, Trinder J, Pierce R, Colrain IM. Evidence of a sleep-specific blunted cortical response to inspiratory occlusions in mild obstructive sleep apnea syndrome. Am J Respir Crit Care Med 166: 1225-1234, 2002.
17. Greenberg HE, Scharf SM. Depressed ventilatory load compensation in sleep apnea. Reversal by nasal CPAP. Am Rev Respir Dis 148: 1610-1615, 1993.
18. Iber C, Berssenbrugge A, Skatrud JB, Dempsey JA. Ventilatory adaptations to resistive loading during wakefulness and non-REM sleep. J Appl Physiol 52: 607-614, 1982.
19. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 14: 540-545, 1991.
20. Kelsen SG, Altose MD, Stanley NN, Levinson RS, Cherniack NS, Fishman AP. Effect of hypoxia on the pressure developed by inspiratory muscles during airway occlusion. J Appl Physiol 40: 372-378, 1976.
21. Kim HC, Young T, Matthews CG, Weber SM, Woodward AR, Palta M. Sleep-disordered breathing and neuropsychological deficits. A population-based study. Am J Respir Crit Care Med 156: 1813-1819, 1997.
22. McNicholas WT, Bowes G, Zamel N, Phillipson EA. Impaired detection of added inspiratory resistance in patients with obstructive sleep apnea. Am Rev Respir Dis 129: 45-48, 1984.
23. Neubauer JA, Melton JE, Edelman NH. Modulation of respiration during brain hypoxia. J Appl Physiol 68: 441-451, 1990.
24. Orr RS, Jordan AS, Catcheside P, Saunders NA, McEvoy RD. Sustained isocapnic hypoxia suppresses the perception of the magnitude of inspiratory resistive loads. J Appl Physiol 89: 47-55, 2000.
25. Phillipson EA, Kozar LF, Murphy E. Respiratory load compensation in awake and sleeping dogs. J Appl Physiol 40: 895-902, 1976.
26. Pillar G, Schnall RP, Peled N, Oliven A, Lavie P. Impaired respiratory response to resistive loading during sleep in healthy offspring of patients with obstructive sleep apnea. Am J Respir Crit Care Med 155: 1602-1608, 1997.
27. Rajagopal KR, Abbrecht PH, Tellis CJ. Control of breathing in obstructive sleep apnea. Chest 85: 174-180, 1984.
28. Rechtschaffen A, Kales A. A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. Washington, DC: Public Health Service, US Government Printing Office, 1963.
29. Sampson MG, Grassino AE. Load compensation in obese patients during quiet tidal breathing. J Appl Physiol 55: 1269-1276, 1983.
30. Tun Y, Hida W, Okabe S, Kikuchi Y, Kurosawa H, Tabata M, Shirato K. Inspiratory effort sensation to added resistive loading in patients with obstructive sleep apnea. Chest 118: 1332-1338, 2000.
31. Wang LY, Cerny FJ. Ventilatory response to exercise in simulated obesity by chest loading. Med Sci Sports Exerc 36: 780-786, 2004.
32. Whitelaw WA, Derenne JP, Couture J, Milic-Emili J. Adaptation of anesthetized men to breathing through an inspiratory resistor. J Appl Physiol 41: 285-291, 1976.
33. Wiegand L, Zwillich CW, White DP. Sleep and the ventilatory response to resistive loading in normal men. J Appl Physiol 64: 1186-1195, 1988.
34. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328: 1230-1235, 1993.
35. Zin WA, Behrakis PK, Luijendijk SC, Higgs BD, Baydur A, Boddener A, Milic-Emili J. Immediate response to resistive loading in anesthetized humans. J Appl Physiol 60: 506-512, 1986.